Rhabdomyolysis: Difference between revisions
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from the patient to look at various serum values, one of the most important | from the patient to look at various serum values, one of the most important | ||
serum indicators of myocyte injury is creatinine kinase.<sup>ef[[Image:Table 2.png|right]] | serum indicators of myocyte injury is creatinine kinase.<sup>ef[[Image:Table 2.png|right]] | ||
</sup></span> | </sup></span> | ||
===== '''<span style="font-family:Helvetica">Creatinine Kinase</span>''' ===== | ===== '''<span style="font-family:Helvetica">Creatinine Kinase</span>''' ===== | ||
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be raised to 10.000-200.000 U/L or even 3.000.000.000 U/L.<span style="mso-spacerun: yes"> </span>No other condition except rhabdomyolysis can cause such extreme CK elevation.”<sup>Ef </sup><span style="mso-spacerun: yes"> </span>Creatine Kinase has several forms that include the muscles, heart, brain and kidneys, as well as mitochndria so it is important to look at all values.</span> | be raised to 10.000-200.000 U/L or even 3.000.000.000 U/L.<span style="mso-spacerun: yes"> </span>No other condition except rhabdomyolysis can cause such extreme CK elevation.”<sup>Ef </sup><span style="mso-spacerun: yes"> </span>Creatine Kinase has several forms that include the muscles, heart, brain and kidneys, as well as mitochndria so it is important to look at all values.</span> | ||
===== '''<span style="font-family:Helvetica">Uric Acid</span>''' ===== | ===== '''<span style="font-family:Helvetica">Uric Acid</span>''' ===== | ||
<span style="font-family:Helvetica">Uric Acid is important | <span style="font-family:Helvetica">Uric Acid is important | ||
to check due to the fact that rhabdomyolysis breaks down skeletal muscle | to check due to the fact that rhabdomyolysis breaks down skeletal muscle | ||
creating more creatinine, which then becomes creatinine which can then lead to | creating more creatinine, which then becomes creatinine which can then lead to | ||
acute renal failure, therefore causing the levels of uric acid to rise.</span> | acute renal failure, therefore causing the levels of uric acid to rise.</span> | ||
'''<span style="font-family:Helvetica">Urinalysis[[Image:Table 3.png|right]]</span>'''<br> | |||
</span>''' | |||
<span style="font-family:Helvetica">Urine | <span style="font-family:Helvetica">Urine |
Revision as of 04:04, 6 March 2010
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
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Definition/Description[edit | edit source]
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Prevalence[edit | edit source]
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Characteristics/Clinical Presentation[edit | edit source]
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Associated Co-morbidities[edit | edit source]
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
Blood samples are taken
from the patient to look at various serum values, one of the most important
serum indicators of myocyte injury is creatinine kinase.
ef
Creatinine Kinase[edit | edit source]
“ Under normal conditions, CK levels are 45-260 U/L. After rhabdomyolysis, the levels of CK can be raised to 10.000-200.000 U/L or even 3.000.000.000 U/L. No other condition except rhabdomyolysis can cause such extreme CK elevation.”Ef Creatine Kinase has several forms that include the muscles, heart, brain and kidneys, as well as mitochndria so it is important to look at all values.
Uric Acid[edit | edit source]
Uric Acid is important to check due to the fact that rhabdomyolysis breaks down skeletal muscle creating more creatinine, which then becomes creatinine which can then lead to acute renal failure, therefore causing the levels of uric acid to rise.
UrinalysisUrine analysis can be very helpful in diagnosing rhabdomyolysis. Urinalysis will be able to detect changes in the body’s waste, such as increases in uric acid, albumin, as well as myoglobin.ef Often patients that are positive for rhabdomyolysis have brown tinted urine. Table 3 has a description of common findings in urinalysis.
Causes[edit | edit source]
Causes for rhabdomyolysis can be broken down into 2 categories, hereditary causes and acquired causes.
Hereditary Causes[edit | edit source]
Those that are at risk for rhabdomyolysis have a family history of disorders dealing with carbohydrate metabolism as well as disorders of lipid metabolism. Disorders of lipid metabolism include malignant hyperthermia, mitochondrial disorders, as well as other genetic disorders.
Acquired Causes[edit | edit source]
Some of the most common acquired causes include trauma or crush injury, toxic, sever muscle exertion, seizures, shaking chills, delerium tremors, ischemia or muscle necrosis, metabolic disorders, bacterial and viral infections, heat-induced (malignant hyperthermia, heat intolerance, heat stroke), inflammatory, certain drugs (overuse or overdose) such as cocaine, amphetamines, statins, heroin, PCP, as well as low phosphate levels.
Below is a chart that describes the risk factors for rhabdomyolysis as well as examples of the risk factors and associated signs and symptoms.
Risk Factors For Postoperative Rhabdomyolysis[edit | edit source]
Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Alternative/Holistic Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Case Reports[edit | edit source]
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