Preeclampsia
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Introduction[edit | edit source]
Preeclampsia is a life-threatening cardiovascular disorder associated with pregnancy. Preeclampsia is marked by hypertension and proteinuria at 20 weeks of gestation. The underlying cause is not precisely known but likely heterogenous. Ample research suggests that for some women with preeclampsia, both maternal and placental vascular dysfunction plays a part in its' evolution and can carry on into the postpartum period. Possible changes include impaired placentation, and endothelial damage.[1]
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Preeclampsia is associated with an increased relative risk for the development of end-stage kidney disease (ESKD) in the mother.
Research shows that women with a history of preeclampsia are 60% more likely to experience ischemic stroke and also have an increased risk of hemorrhagic stroke and venous thromboembolism[2].
Women with a history of preeclampsia have increased white matter hyperintensities on brain magnetic resonance imaging9,106, a marker of cerebral small vessel disease that is highly associated with stroke and dementia [3]
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References[edit | edit source]
- ↑ Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ. Vascular dysfunction in preeclampsia. Cells. 2021 Nov 6;10(11):3055.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616535/ (accessed 5.3.2024)
- ↑ Turbeville HR, Sasser JM. Preeclampsia beyond pregnancy: long-term consequences for mother and child. American Journal of Physiology-Renal Physiology. 2020 Jun 1;318(6):F1315-26.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311709/ (accessed 5.3.2024)
- ↑ Miller EC. Preeclampsia and cerebrovascular disease: the maternal brain at risk. Hypertension. 2019 Jul;74(1):5-13.Available:https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11513 (accessed 5.3.2024)
