Pain Descending Pathways

Welcome to PPA Pain Project. This page is being developed by participants of a project to populate the Pain section of Physiopedia.  The project is supervised and co-ordinated by the The Physiotherapy Pain Association.
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Tips for writing this page:

  • Describe the descending pathways that modulate pain transmission
  • Describe their purpose, how they are activated  and how their actions might impact upon a pain experince

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Top Contributors - Adrian Mallows, Lucinda hampton, Jo Etherton, Admin and Lauren Lopez  

The descending pain modulatory system[edit | edit source]

The "top down" modulation of pain has been in evidence since the early work of Sherrington[1]

The role of the brain stem[edit | edit source]

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Neurochemical underpinnings[edit | edit source]

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References[edit | edit source]

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  1. Sherrington CS. The intergrative action of the nervous system. New Haven, CT:Yale University Press;2004