Gilbert's Syndrome: Difference between revisions
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== Definition/Description == | == Definition/Description == | ||
Gilbert’s syndrome is a benign liver condition that is characterized by elevated levels of bilirubin in the blood.(<ref>1</ref>,<ref>2</ref>) Bilirubin is produced by the breakdown of red blood cells and is able to be removed from the body after the liver converts it from unconjugated bilirubin to conjugated bilirubin.(<ref>1</ref>,<ref>3</ref>,<ref>4</ref>) In individuals with Gilbert’s syndrome, there is a buildup of unconjugated bilirubin in the liver as a result of a genetic mutation of the enzyme UDP-glucuronosyltransferase 1A isoform 1 (UGT1A1), which is important in bilirubin metabolism.(<ref>4</ref>,<ref>5</ref>) The buildup of bilirubin is particularly evident after starvation, exertion, infection, consumption of alcohol, or dehydration.(5) Bilirubin levels fluctuate and rarely increase to levels that cause jaundice.(<ref>1</ref>)<br> | Gilbert’s syndrome is a benign liver condition that is characterized by elevated levels of bilirubin in the blood.(<ref>1</ref>,<ref>2</ref>) Bilirubin is produced by the breakdown of red blood cells and is able to be removed from the body after the liver converts it from unconjugated bilirubin to conjugated bilirubin.(<ref>1</ref>,<ref>3</ref>,<ref>4</ref>) In individuals with Gilbert’s syndrome, there is a buildup of unconjugated bilirubin in the liver as a result of a genetic mutation of the enzyme UDP-glucuronosyltransferase 1A isoform 1 (UGT1A1), which is important in bilirubin metabolism.(<ref>4</ref>,<ref>5</ref>) The buildup of bilirubin is particularly evident after starvation, exertion, infection, consumption of alcohol, or dehydration.(5) Bilirubin levels fluctuate and rarely increase to levels that cause jaundice.(<ref>1</ref>)<references /><br> | ||
== Prevalence == | == Prevalence == | ||
Revision as of 20:57, 5 April 2017
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Top Contributors - J.Dylan James, Elaine Lonnemann, WikiSysop, Kim Jackson and 127.0.0.1
Definition/Description[edit | edit source]
Gilbert’s syndrome is a benign liver condition that is characterized by elevated levels of bilirubin in the blood.([1],[2]) Bilirubin is produced by the breakdown of red blood cells and is able to be removed from the body after the liver converts it from unconjugated bilirubin to conjugated bilirubin.([3],[4],[5]) In individuals with Gilbert’s syndrome, there is a buildup of unconjugated bilirubin in the liver as a result of a genetic mutation of the enzyme UDP-glucuronosyltransferase 1A isoform 1 (UGT1A1), which is important in bilirubin metabolism.([6],[7]) The buildup of bilirubin is particularly evident after starvation, exertion, infection, consumption of alcohol, or dehydration.(5) Bilirubin levels fluctuate and rarely increase to levels that cause jaundice.([8])
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