Exercise and Nerve Regeneration: Difference between revisions
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=== Neurotrophin-Dependent Mechanism === | === Neurotrophin-Dependent Mechanism === | ||
Neurotrophins are regulative proteins that are expressed in the nervous system. Their neuronal functions are diverse, ranging from neurogenesis to programmed cell death. <ref>Nordvall G, Forsell P, Sandin J. Neurotrophin-targeted therapeutics: A gateway to cognition and more?. Drug discovery today. 2022 Oct 1;27(10):103318.</ref> | |||
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophins family known for it's role in inducing plastic changes that regulate neuronal growth, excitability, and even regeneration. <ref>Jin Y, Fischer I, Tessler A, Houle JD. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Experimental neurology. 2002 Sep 1;177(1):265-75.</ref> <ref>Garraway SM, Huie JR. Spinal plasticity and behavior: BDNF-induced neuromodulation in uninjured and injured spinal cord. Neural plasticity. 2016 Oct;2016.</ref>A study <ref>LeechKristan A, George H. High-intensity locomotor exercise increases brain-derived neurotrophic factor in individuals with incomplete spinal cord injury. Journal of neurotrauma. 2017 Mar 15.</ref> found a correlation between serum levels of BDNF and exercise intensity in humans with spinal injury. | |||
=== Transcription Factor Activation === | === Transcription Factor Activation === | ||
Revision as of 22:22, 25 April 2024
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Introduction[edit | edit source]
Effect Mechanisms of Exercise on Nerve Regeneration[edit | edit source]
Neurotrophin-Dependent Mechanism[edit | edit source]
Neurotrophins are regulative proteins that are expressed in the nervous system. Their neuronal functions are diverse, ranging from neurogenesis to programmed cell death. [1]
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophins family known for it's role in inducing plastic changes that regulate neuronal growth, excitability, and even regeneration. [2] [3]A study [4] found a correlation between serum levels of BDNF and exercise intensity in humans with spinal injury.
Transcription Factor Activation[edit | edit source]
Resources[edit | edit source]
References[edit | edit source]
- ↑ Nordvall G, Forsell P, Sandin J. Neurotrophin-targeted therapeutics: A gateway to cognition and more?. Drug discovery today. 2022 Oct 1;27(10):103318.
- ↑ Jin Y, Fischer I, Tessler A, Houle JD. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Experimental neurology. 2002 Sep 1;177(1):265-75.
- ↑ Garraway SM, Huie JR. Spinal plasticity and behavior: BDNF-induced neuromodulation in uninjured and injured spinal cord. Neural plasticity. 2016 Oct;2016.
- ↑ LeechKristan A, George H. High-intensity locomotor exercise increases brain-derived neurotrophic factor in individuals with incomplete spinal cord injury. Journal of neurotrauma. 2017 Mar 15.
