End Organ

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Top Contributors - Lucinda hampton  

Introduction

An end organ is the last organ affected in a chain of events, for instance a disease process.

Examples are the liver, brain or kidney, and are ultimately affected by a chronic or progressive disease or condition like diabetes or hypertension.

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A pathological change in the microcirculation plays a pivotal role in promoting end-organ dysfunction that not only predisposes to further organ damage, but also increases the risk for future macrovascular events.

• Arterial hypertensive is a risk factor for end organ damage, and can now be diagnosed early and reversed with specific and aggressive treatment.
• Obesity is a risk factor for development of target organ damage, due to development of hypertension, and needs adressing early for prevention of such.
• Similar to arterial hypertension and obesity, type 2 diabetes mellitus is associated with target organ damage

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