Ebola Virus
Original Editors - Leann Bruce and Kara Cannon from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Top Contributors - Leann Bruce, Kara Cannon, Ylice Bridges, Kim Jackson, Elaine Lonnemann, WikiSysop, Nupur Smit Shah, 127.0.0.1 and Evan Thomas
Definition/Description[edit | edit source]
“Ebola Virus Disease (EVD) is a severe, often fatal, zoonotic infection caused by a virus of the Filoviridae family (genus Ebolavirus),”1. EVD is one type of hemorrhagic fever that is commonly found in west, central, and east Africa. The disease is caused by a single-stranded RNA Flavovirus which tends to replicate on dendritic cells, macrophages, and monocytes. The virus then uses multiple mechanisms to invade its host including migration to the spleen, liver, and lymph nodes which leads to widespread infection.1 There are five known strains of EVD: Zaire ebolavirus, Bundibugyo virus, Sudan Virus, Taï Forest virus, and Reston virus. Of the five strains, only the Reston virus has not affected humans. The other strains have fatality rates ranging from 30-90% depending on the specific outbreak.2
EVD originates in animals and is spread to humans through hunting and eating of bushmeat or contact with bat feces. Once a human has EVD, the virus is spread through contact with bodily fluids or reuse of needles that have not been properly decontaminated.1 “Classification by the Centers for Disease Control as a category A agent also designates EBOV as a bioterrorism threat, making this virus a biodefense research priority”3.
Prevalence[edit | edit source]
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Characteristics/Clinical Presentation[edit | edit source]
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Associated Co-morbidities[edit | edit source]
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Etiology/Causes[edit | edit source]
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Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Case Reports/ Case Studies[edit | edit source]
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Resources
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Recent Related Research (from Pubmed)[edit | edit source]
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References[edit | edit source]
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