Critical Illness Polyneuropathy (CIP)
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Definition
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Critical Illness Polyneuropathy (CIP) is one of three classifications of Intensive care -unit acquired weakness (ICUAW), the others being Critical Illness Myopathy (CIM) and Critical Illness Neuromyopathy (CINM)[1]. ICUAW is defined as 'a clinically detected weakness in critically ill patients in whom there is no plausable aetiology other than critical illness' [2]
Clinically Relevant Anatomy
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Pathological Process[edit | edit source]
The pathophysiology for CIP remains unclear and complex, with human studies highlighting axonal degeneration [3].It has been thought that the mechanism may involve:
- Microvascular alterations: Increase in E- Selectin expression, vasodilation, increased capillary permeability, extravasation and endoneural oedema which results in hypoxia.
- Metabolic alterations: Production of toxic factors such as cytokines, hyperglycaemia, hormone imbalance, hypoalbuminemia, amina acid deficiency and activation of proteolytic pathways.
- Electrical alterations: Ion channel dysfunction, cell depolarisation, inexcitability, altered calcium homeostasis and changes in excitation-contraction coupling.
- Bionenergetic failure: Anti-oxident depletion, an increase in reactive oxygen species, mitochrondial dysfunction and apoptosis.
Clinical Presentation[edit | edit source]
Diagnostic Procedures[edit | edit source]
Outcome Measures[edit | edit source]
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Management / Interventions
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Differential Diagnosis
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Resources
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References[edit | edit source]
- ↑ Appleton, R. and Kinsella, J., 2012. Intensive care unit-acquired weakness. Continuing Education in Anaesthesia, Critical Care and Pain, 12(2), pp.62-66.
- ↑ Stevens, R.D., Marshall, S.A., Cornblath, D.R., Hoke, A., Needham, D.M., de Jonghe, B., Ali, N.A. and Sharshar, T., 2009. A framework for diagnosing and classifying intensive care unit-acquired weakness. Critical care medicine, 37(10), pp.S299-S308.
- ↑ Zhou, C., Wu, L., Ni, F., Ji, W., Wu, J. and Zhang, H., 2014. Critical illness polyneuropathy and myopathy: a systematic review. Neural regeneration research, 9(1), p.101.
