Chemotherapy-Induced Peripheral Neuropathy (CIPN): Difference between revisions
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* No recommendations for treatment of CIPN in regards to exercise therapy, [[acupuncture]], scrambler therapy, gabapentin, pregabalin, topical gel treatment (containing baclofen/amitriptyline plus/minus ketamine), tricyclic antidepressants or oral cannabinoids.<ref name=":0" /> | * No recommendations for treatment of CIPN in regards to exercise therapy, [[acupuncture]], scrambler therapy, gabapentin, pregabalin, topical gel treatment (containing baclofen/amitriptyline plus/minus ketamine), tricyclic antidepressants or oral cannabinoids.<ref name=":0" /> | ||
== | == Physiotherapy == | ||
[[Nerve Injury Rehabilitation|Physiotherapy]] is an important therapy intervention for people with neuropathies. Through individualised treatment plans and interventions, it aims to improve movement and relieve pain and discomfort. The scope of these interventions ranges from strengthening exercises designed to address muscle weakness, to balance exercises that address fall risks. For more see [[Neuropathies|here]] | |||
== References == | == References == | ||
Revision as of 03:10, 19 August 2023
Original Editor - Lucinda hampton
Top Contributors - Lucinda hampton and Mason Trauger
Introduction[edit | edit source]
Chemotherapy-induced peripheral neuropathy (CIPN) commonly occurs as an adverse event following chemotherapy.CIPN can have an effect on the sensory, motor and/or autonomic nerves[1].
Currently there is no gold standard for diagnosis, no proven ways to lessen or stop this condition and treatment strategies need be addressed.[1]
CIPN regularly impacts chemotherapy, occasionally requiring the dose to be reduced or treatment ceased, effecting survival. Around 30% of patients will still have CIPN a year, or more post chemotherapy[2].
Physiotherapy, in the form of exercise therapy, has been shown to have a role in reducing symptoms in CIPN[3].
Risk Factors[edit | edit source]
Include: Agent used, cumulative dose, how many treatment cycles and its duration, genetic susceptibility, age, any existing nerve damage, severity of acute symptom, chronic alcohol consumption.[1]
Treatment[edit | edit source]
Pharmacological: Pharmacological treatment for peripheral neuropathic pain is not very effective and also may have serious harmful consequences[4]. Treatment option for symptoms include:
- Steroids, to lessen inflammation
- Topical anesthetics
- Antiseizure medications, which can help relieve nerve pain
- Opioids
- Antidepressants
Non pharmacological:
- Transcutaneous electrical nerve stimulation
- Physical therapy
- Occupational therapy
Note. Recently published American Society of Clinical Oncology (ASCO) guidelines
- Suggest strongly that duloxetine (a serotonin–norepinephrine reuptake inhibitor) is the only currently recommended treatment.
- No recommendations for treatment of CIPN in regards to exercise therapy, acupuncture, scrambler therapy, gabapentin, pregabalin, topical gel treatment (containing baclofen/amitriptyline plus/minus ketamine), tricyclic antidepressants or oral cannabinoids.[1]
Physiotherapy[edit | edit source]
Physiotherapy is an important therapy intervention for people with neuropathies. Through individualised treatment plans and interventions, it aims to improve movement and relieve pain and discomfort. The scope of these interventions ranges from strengthening exercises designed to address muscle weakness, to balance exercises that address fall risks. For more see here
References[edit | edit source]
- ↑ 1.0 1.1 1.2 1.3 Burgess J, Ferdousi M, Gosal D, Boon C, Matsumoto K, Marshall A, Mak T, Marshall A, Frank B, Malik RA, Alam U. Chemotherapy-induced peripheral neuropathy: epidemiology, pathomechanisms and treatment. Oncology and therapy. 2021 Dec 1:1-66.Available:https://pubmed.ncbi.nlm.nih.gov/33490836/ (accessed 18.8.2023)
- ↑ Colvin LA. Chemotherapy-induced peripheral neuropathy (CIPN): where are we now?. Pain. 2019 May;160(Suppl 1):S1.Available:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499732/ (accessed 19.8.2023)
- ↑ Jesson T, Runge N, Schmid AB. Physiotherapy for people with painful peripheral neuropathies: a narrative review of its efficacy and safety. Pain Reports. 2020 Sep;5(5).Available: https://pubmed.ncbi.nlm.nih.gov/33490836/(accessed 18.8.2023)
- ↑ Jesson T, Runge N, Schmid AB. Physiotherapy for people with painful peripheral neuropathies: a narrative review of its efficacy and safety. Pain Reports. 2020 Sep;5(5).Available:https://pubmed.ncbi.nlm.nih.gov/33490836/ (accessed 19.8.2023)
