Biomarkers of Parkinson's Disease
Original Editor - Arnold Fredrick D'Souza
Top Contributors - Arnold Fredrick D'Souza, Libby McConnell, Kim Jackson and Lucinda hampton
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An introduction to Biomarkers[edit | edit source]
The Biomarkers Definitions Working Group defines biomarkers (biological markers) as ‘‘a measurable indicator of some biological state or condition that is objectively measured and evaluated to examine normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.’’ Biomarkers could be a used as a diagnostic tool, disease staging tool, prognostic tool, or for predicting and monitoring the clinical response to an intervention.[1] Biomarkers can have molecular, histological, radiographical, or physiological characteristics.[2]
Biomarkers and Parkinson's disease[edit | edit source]
Based on their characteristics, biomarkers of Parkinson's disease can be classified into 4 major categories:
- Clinical
- Genetic
- Neuroimaging
Application in physiotherapy research[edit | edit source]
Oral biomarkers of exercise-induced neuroplasticity in Parkinson's disease[edit | edit source]
Resources[edit | edit source]
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References[edit | edit source]
- ↑ Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001 Mar;69(3):89-95.
- ↑ FDA-NIH Biomarker Working Group. BEST (Biomarkers, EndpointS, and other Tools) Resource [Internet]. Silver Spring (MD): Food and Drug Administration (US); 2016 Jan 28 [Updated 2021 Nov 29].
