Adverse Response

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Definition[edit | edit source]

The Cambridge Dictionary has defined an "adverse reaction" as "a harmful physical effect caused by a drug, a medical treatment, or another substance." In current research, there is not standard terminology nor definitions for adverse responses in physical therapy. Terms such as adverse events, adverse reactions, adverse effects, side effects, complications, and safety are commonly used interchangeably[1]. This can cause difficulty in finding accurate data at times.

Responses[edit | edit source]

Most reported adverse responses come from a manual therapy intervention such as spinal manipulation or dry needling. The types of adverse responses can vary greatly from mild to severe. Some common patient reported responses include[2]:

  • Stiffness or increased stiffness
  • Soreness or increased soreness
  • Increase in symptoms
  • Spread of symptoms
  • Headaches
  • Fatigue
  • Increased pain

Serious responses that are reported include[3]:

  • Death
  • Stroke
  • Paralysis
  • Fractures

One study did find that 61% of all patients reporting at least 1 of the "mild" symptoms (headache, stiffness, local discomfort, radiating discomfort, and fatigue) [4] . Another found the rate of an adverse response to between 1 in 20,000 to 1 in 250,000,000 manipulations which included the serious responses [3].

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Resources[edit | edit source]

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References[edit | edit source]

  1. Carlesso, L. C., MacDermid, J. C., & Santaguida, L. P. (2010). Standardization of adverse event terminology and reporting in orthopaedic physical therapy: application to the cervical spine. journal of orthopaedic & sports physical therapy, 40(8), 455-463.
  2. Funabashi, M., & Carlesso, L. C. (2021). Symptoms patients receiving manual therapy experienced and perceived as adverse: a secondary analysis of a survey of patients’ perceptions of what constitutes an adverse response. Journal of Manual & Manipulative Therapy, 29(1), 51-58.
  3. 3.0 3.1 Nielsen, S.M., Tarp, S., Christensen, R. et al. The risk associated with spinal manipulation: an overview of reviews. Syst Rev 6, 64 (2017). https://doi.org/10.1186/s13643-017-0458-y
  4. Ernst E. (2007). Adverse effects of spinal manipulation: a systematic review. Journal of the Royal Society of Medicine, 100(7), 330–338. https://doi.org/10.1177/014107680710000716