Adult neurogenesis: Difference between revisions
No edit summary |
No edit summary |
||
| Line 12: | Line 12: | ||
Back in the 1800s and the first half of the 20th century, scientists and scholars believed that development of new neurons only occurred early in life and would cease at some point during development, so that no new neurons could be formed in the brain or spinal cord after this 'critical age'. Some scientists back then disputed this as fact but had no means of disproving the widely accepted notion, the non-availability of advanced equipment back then and less advanced scientific investigation and laboratoty techniques meant this notion would go unchallenged for a very long time. | Back in the 1800s and the first half of the 20th century, scientists and scholars believed that development of new neurons only occurred early in life and would cease at some point during development, so that no new neurons could be formed in the brain or spinal cord after this 'critical age'. Some scientists back then disputed this as fact but had no means of disproving the widely accepted notion, the non-availability of advanced equipment back then and less advanced scientific investigation and laboratoty techniques meant this notion would go unchallenged for a very long time. | ||
== Current opinions/Key evidence == | == Current opinions/Key evidence == | ||
In the 1960s, some very brave scientists began to use the more advanced techniques of that time to demonstrate that some mitotic figures could be identified in the brains of adult birds. This generated a lot of interest and a shift of focus was made to the mammalian species which were considered to be more advanced species and closer to the human being. adult neurogenesis was discovered in progressively higher orders of the mammalian species from the rodents (laboratory rats and mice) to the primates such as chimpanzees and monkeys. In 1998 a scientist by the name of Peter Ericksson and his team were the first to conclusively demonstrate that adult generated neurons could be identified in the human brain as well. Two areas have been consistently identified across all species studied to date, which are the subgranular zone of the hippocampus (hippocampus is responsible for spatial memory) and the subventricular zone of the lateral ventricles (the area from which neurons migrate to form the cerebral hemispheres and cerebral cortex in the embryonic and fetal periods). | |||
== Clinically relevant Anatomy == | == Clinically relevant Anatomy == | ||
Revision as of 13:33, 13 February 2016
Original Editor - Your name will be added here if you created the original content for this page.
Lead Editors
Historical perspective[edit | edit source]
"Adult neurogenesis" refers to the ability of the central nervous system (brain and spinal cord) to generate new neurons in adulthood called adult generated neurons. This is as differentiated from "neurogenesis" typically used to describe the processes of neuronal generation that occur during the prenatal (embryonic and fetal) period extending in to the early years of postnatal life.
Back in the 1800s and the first half of the 20th century, scientists and scholars believed that development of new neurons only occurred early in life and would cease at some point during development, so that no new neurons could be formed in the brain or spinal cord after this 'critical age'. Some scientists back then disputed this as fact but had no means of disproving the widely accepted notion, the non-availability of advanced equipment back then and less advanced scientific investigation and laboratoty techniques meant this notion would go unchallenged for a very long time.
Current opinions/Key evidence[edit | edit source]
In the 1960s, some very brave scientists began to use the more advanced techniques of that time to demonstrate that some mitotic figures could be identified in the brains of adult birds. This generated a lot of interest and a shift of focus was made to the mammalian species which were considered to be more advanced species and closer to the human being. adult neurogenesis was discovered in progressively higher orders of the mammalian species from the rodents (laboratory rats and mice) to the primates such as chimpanzees and monkeys. In 1998 a scientist by the name of Peter Ericksson and his team were the first to conclusively demonstrate that adult generated neurons could be identified in the human brain as well. Two areas have been consistently identified across all species studied to date, which are the subgranular zone of the hippocampus (hippocampus is responsible for spatial memory) and the subventricular zone of the lateral ventricles (the area from which neurons migrate to form the cerebral hemispheres and cerebral cortex in the embryonic and fetal periods).
Clinically relevant Anatomy[edit | edit source]
add text here relating to the clinical presentation of the condition
Adult neurogenesis and neurological disease[edit | edit source]
add text here relating to diagnostic tests for the condition
Physiotherapist's role[edit | edit source]
add links to outcome measures here (see Outcome Measures Database)
Resources
[edit | edit source]
add appropriate resources here
Recent Related Research (from Pubmed)[edit | edit source]
Extension:RSS -- Error: Not a valid URL: Feed goes here!!|charset=UTF-8|short|max=10
References[edit | edit source]
References will automatically be added here, see adding references tutorial.
