Acute Motor Axonal Neuropathy: Difference between revisions
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=== Introduction === | |||
Acute motor axonal neuropathy (AMAN) is classified as a subtype of [[Guillain-Barre Syndrome|Guillain–Barré syndrome (GBS)]]<ref name=":0">Lv J, Zhaori G. [[/www.ncbi.nlm.nih.gov/pmc/articles/PMC8960912/|Collaborative studies of U.S.–China neurologists on acute motor axonal neuropathy - PMC (nih.gov)]] Pediatr Investig. 2022 Mar 22;6(1):1-4. doi: 10.1002/ped4.12316. PMID: 35382424; PMCID: PMC8960912.</ref>. The disease was first discovered in China and was nicknamed 'chinese paralytic disease'<ref name=":0" />. AMAN is the most common cause of flaccid paralysis in China<ref>McKhann GM, Cornblath DR, Griffin JW, Ho TW, Li CY, Jiang Z, Wu HS, Zhaori G, Liu Y, Jou LP, Liu TC. [https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.410330402 Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China]. Annals of neurology. 1993 Apr;33(4):333-42.</ref>. Pathology in AMAN patients are usually limited to the motor nerve, with macrophages destroying axons while myelin remains intact, a contrast to AIDP GBS (most common form of GBS) which is known as a demyelinating disease<ref name=":0" />. While AMAN mainly involves axonal damage to motor nerve fibers; acute inflammatory demyelinating polyradiculoneuropathy (AIDP) involves both motor and sensory nerve fiber damage due to demyelination<ref name=":0" />. | |||
=== Clinical features === | |||
AMAN presents similarly in terms of clinical features as well as CSF findings to GBS<ref name=":0" />. | |||
* Weakness of limbs (earliest symptom is weakness of lower limbs) | |||
* Weakness of respiratory muscles | |||
* Gradual weakening and finally, absence of tendon reflexes | |||
* Bulbar palsy in 61% of patients<ref name=":0" /> | |||
Revision as of 01:21, 8 April 2024
Introduction[edit | edit source]
Acute motor axonal neuropathy (AMAN) is classified as a subtype of Guillain–Barré syndrome (GBS)[1]. The disease was first discovered in China and was nicknamed 'chinese paralytic disease'[1]. AMAN is the most common cause of flaccid paralysis in China[2]. Pathology in AMAN patients are usually limited to the motor nerve, with macrophages destroying axons while myelin remains intact, a contrast to AIDP GBS (most common form of GBS) which is known as a demyelinating disease[1]. While AMAN mainly involves axonal damage to motor nerve fibers; acute inflammatory demyelinating polyradiculoneuropathy (AIDP) involves both motor and sensory nerve fiber damage due to demyelination[1].
Clinical features[edit | edit source]
AMAN presents similarly in terms of clinical features as well as CSF findings to GBS[1].
- Weakness of limbs (earliest symptom is weakness of lower limbs)
- Weakness of respiratory muscles
- Gradual weakening and finally, absence of tendon reflexes
- Bulbar palsy in 61% of patients[1]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Lv J, Zhaori G. Collaborative studies of U.S.–China neurologists on acute motor axonal neuropathy - PMC (nih.gov) Pediatr Investig. 2022 Mar 22;6(1):1-4. doi: 10.1002/ped4.12316. PMID: 35382424; PMCID: PMC8960912.
- ↑ McKhann GM, Cornblath DR, Griffin JW, Ho TW, Li CY, Jiang Z, Wu HS, Zhaori G, Liu Y, Jou LP, Liu TC. Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Annals of neurology. 1993 Apr;33(4):333-42.
