Radiation Side Effects and Syndromes
Original Editors -Alicia Dupilka & Kristin Gramling from Bellarmine University's Pathophysiology of Complex Patient Problems project.
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Definition/Description[edit | edit source]
Radiation therapy is when radiation is delivered to a specific area of the body to try and treat a disease, usually cancer. The goal of the radiation is to kill rapidly dividing cancer cells while sparing slower dividing somatic cells.[1] Radiation is usually used in conjuction with surgery or chemotherapy.
Prevalence[edit | edit source]
Nearly two-thirds of all cancer patients will recieve radiation therapy.[2]
Characteristics/Clinical Presentation[edit | edit source]
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Associated Co-morbidities[edit | edit source]
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Etiology/Cause[2][edit | edit source]
Risk Factors:
Dependent on organ radiated, individual tolerance, tumor type, volume radiated and fraction size/dosage.
Neurotoxicity
- High total dose and fractionation dose
- Large volume radiated
- Increased edema
- Age <12 or >60 years
- Concurrent chemotherapy
- Underlying diseases affecting the vascular structures (Diabetes, HTN)
- Stereotactic radiation surgery and brachytherapy (internal radiation)
Dermatitis
- Total dose/volume and fractionation dose
- Surface area exposed
Acute Enterocolitis
- Large volume
- High total dose and fractionation dose
- Concurrent chemotherapy
Chronic Entercolitis
- Older age
- Postoperative radiation
- Presence of collagen vascular disease
- Concurrent chemotherapy
- Poor radiation technique
Pulmonary
- Older age
- Lower performance status
- Lower pulmonary baseline function
- Large volume treated
Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Alternative/Holistic Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Case Reports/ Case Studies[edit | edit source]
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Resources
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Recent Related Research (from Pubmed)[edit | edit source]
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References[edit | edit source]
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