Radiation Side Effects and Syndromes
Original Editors -Alicia Dupilka & Kristin Gramling from Bellarmine University's Pathophysiology of Complex Patient Problems project.
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Definition/Description[edit | edit source]
Radiation therapy is when radiation is delivered to a specific area of the body to try and treat a disease, usually cancer. The goal of the radiation is to kill rapidly dividing cancer cells while sparing slower dividing somatic cells.1 Radiation is usually used in conjuction with surgery or chemotherapy.
Prevalence[edit | edit source]
Nearly two-thirds of all cancer patients will recieve radiation therapy.2
Characteristics/Clinical Presentation[edit | edit source]
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Associated Co-morbidities[edit | edit source]
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Etiology/Cause2[edit | edit source]
Risk Factors:
Dependent on organ radiated, individual tolerance, tumor type, volume radiated and fraction size/dosage.
Neurotoxicity
- High total dose and fractionation dose
- Large volume radiated
- Increased edema
- Age <12 or >60 years
- Concurrent chemotherapy
- Underlying diseases affecting the vascular structures (Diabetes, HTN)
- Stereotactic radiation surgery and brachytherapy (internal radiation)
Dermatitis
- Total dose/volume and fractionation dose
- Surface area exposed
Acute Enterocolitis
- Large volume
- High total dose and fractionation dose
- Concurrent chemotherapy
Chronic Entercolitis
- Older age
- Postoperative radiation
- Presence of collagen vascular disease
- Concurrent chemotherapy
- Poor radiation technique
Pulmonary
- Older age
- Lower performance status
- Lower pulmonary baseline function
- Large volume treated
Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Alternative/Holistic Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Case Reports/ Case Studies[edit | edit source]
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Resources
[edit | edit source]
1. Stubblefield MD. Radiation Fibrosis Syndrome: Neuromuscular and Musculoskeletal Complication in Cancer Survivors. Physical Medicine and Rehabilitation Journal. Nov 2011;3:1041-1054.
2. Goodman CC, Fuller KS. Pathology: Implication for the Physical Therapist. St. Louis, Missouri: Saunders;2009.
Recent Related Research (from Pubmed)[edit | edit source]
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References[edit | edit source]
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