Transient Global Amnesia
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Introduction[edit | edit source]
Transient global amnesia (TGA) is a clinical syndrome, usually occurring in those over 50, with as yet unknown etiology. TGA is transient in nature, with an acute onset and resolves within a twenty four hours. It is often preceded by such events as very strenuous, migraines, high-stress, or sexual intercourse.[1]
Pathophysiology[edit | edit source]
TGAs are thought to begin in the hippocampus. The region of the hippocampus is an area were blood drains in the brain and is vulnerable to impact from various metabolic stresses. When changes are seen here they are found MRI around 2 days post event after symptoms have gone. [2][1]
Presentation[edit | edit source]
TGA presents neurologically dramatically and may cause great concern to both patient and clinician. Anterograde and partial retrograde amnesia with a duration of less than 24 hours without no lasting symptoms. Semantic memory is less affected than episodic, and most cases memories resolve within a few hours.[3]
Differential Diagnosis[edit | edit source]
Most important to rule out stroke. Other diagnoses include:
- transient epileptic amnesia
- psychogenic amnesia
- drug-related amnesia
- post-traumatic amnesia[4]
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References[edit | edit source]
- ↑ 1.0 1.1 Nehring SM, Spurling BC, Kumar A. Transient global amnesia. InStatPearls [Internet] 2022 Jul 31. StatPearls Publishing.Available:https://www.ncbi.nlm.nih.gov/books/NBK442001/ (accessed 31.3.2023)
- ↑ Enzinger C, Thimary F, Kapeller P, Ropele S, Schmidt R, Ebner F, Fazekas F. Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease. Stroke. 2008 Aug 1;39(8):2219-25.Available:https://www.ahajournals.org/doi/10.1161/STROKEAHA.107.508655 (accessed 31.3.2023)
- ↑ Miller TD, Butler CR. Acute-onset amnesia: transient global amnesia and other causes. Practical Neurology. 2022 Jun 1;22(3):201-8.Available:https://pn.bmj.com/content/22/3/201 (accessed 31.3.2023)
- ↑ Radiopedia Transient Global Amnesia Available:https://radiopaedia.org/articles/transient-global-amnesia (accessed 31.34.2023)
