Muscle Repair

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Top Contributors - Lucinda hampton  

Introduction[edit | edit source]

Skeletal muscle repair requires the activation of satellite cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and extracellular matrix interactions. Immune, fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases

  1. Destruction phase with the initial inflammatory response
  2. Regeneration phase with activation and proliferation of satellite cells
  3. Remodelling phase with maturation of the regenerated myofibers

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