Frontotemporal Dementia

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Introduction[edit | edit source]

The term “Pick’s Disease” (PiD) was named after Arnold Pick for his initial description of focal gross atrophy of the frontotemporal lobes in a patient with progressive language and behavioral disturbances [1]. Pick’s disease is a rare neurodegenerative disorder, estimated to be 10 times less frequent than Alzheimer’s disease, even in regions with high prevalence. It was first clinically described by Pick in 1892 in a woman with lobar brain atrophy who suffered from pre-senile dementia with dysphasia [2].

References[edit | edit source]

  1. Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM. Deep clinical and neuropathological phenotyping of Pick disease. Annals of neurology. 2016 Feb;79(2):272-87.
  2. Dickson DW. Pick's disease: a modern approach. Brain pathology. 1998 Apr;8(2):339-54.