Frontotemporal Dementia

Introduction[edit | edit source]

The term “Pick’s Disease” (PiD) was named after Arnold Pick for his initial description of focal gross atrophy of the frontotemporal lobes in a patient with progressive language and behavioral disturbances [1]. Pick’s disease is a rare neurodegenerative disorder, estimated to be 10 times less frequent than Alzheimer’s disease, even in regions with high prevalence. It was first clinically described by Pick in 1892 in a woman with lobar brain atrophy who suffered from pre-senile dementia with dysphasia [2].

  1. Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM. Deep clinical and neuropathological phenotyping of P ick disease. Annals of neurology. 2016 Feb;79(2):272-87.
  2. Dickson DW. Pick's disease: a modern approach. Brain pathology. 1998 Apr;8(2):339-54.