Purpura
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Top Contributors - Kylie Smith, Lucinda hampton, Elaine Lonnemann, Kim Jackson and WikiSysop
Definition/Description[edit | edit source]
Purpura is a hemorrhagic condition that occurs when not enough normal platelets are available to plug damaged vessels or prevent leakage from even minor injury to normal capillaries. Purpura is characterized by movement of blood into the surrounding tissue (extravasation), under the skin, and through mucous membranes, producing spontaneous ecchymoses (bruises) and petechiae (small, red patches) on the skin [1]. Purpura measure between 4 and 10 mm (millimeters) in diameter. When purpura spots are less than 4 mm in diameter, they are called petechiae. Purpura spots larger than 1 cm (centimeter) are called ecchymoses [2]. There are many different types of purpura. Their classification depends on the appearance or cause of the condition.
Idiopathic thrombocytopenic purpura (ITP), also known as primary immune thrombocytopenic purpura and autoimmune thrombocytopenic purpura, is defined as isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia. ITP has two distinct clinical syndromes, with typical manifestation of an acute condition in children (spontaneous resolution within 2 months) and a chronic condition in adults (lasting longer than 6 months) [3].
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