Hereditary neuropathy with pressure palsies (HNPP): Difference between revisions
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== Introduction == | == Introduction == | ||
Hereditary Neuropathy with Pressure Palsies (HNPP) is a rare | Hereditary Neuropathy with Pressure Palsies (HNPP) is a rare type of peripheral [[Neuropathies|neuropathy]] that affects the peripheral nerves. It is inherited in an autosomal dominant manner meaning individuals have a 50% chance of passing it on to their children. People with HNPP have a higher risk of developing nerve damage when their nerves are exposed to mild pressure or trauma, such as crossing the legs, leaning on the elbows, or wearing tight shoes. This can cause episodes of numbness, tingling, pain, and weakness in the affected areas, which usually last from minutes to months. These episodes are called pressure palsieshb | ||
The cause of HNPP is a mutation in the peripheral myelin protein 22 (PMP22) gene, which is responsible for producing a protein called PMP22. This protein plays a crucial role in the formation and maintenance of myelin, the protective covering around nerve fibers. Unfortunately in HNPP the mutation in the PMP22 gene leads to abnormalities in myelin structure and function resulting in nerve dysfunction. | The cause of HNPP is a mutation in the peripheral myelin protein 22 (PMP22) gene, which is responsible for producing a protein called PMP22. This protein plays a crucial role in the formation and maintenance of myelin, the protective covering around nerve fibers. Unfortunately in HNPP the mutation in the PMP22 gene leads to abnormalities in myelin structure and function resulting in nerve dysfunction. | ||
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Revision as of 14:42, 28 June 2023
Original Editor - Ravi Kumar
Top Contributors - Ravi Kumar
This article or area is currently under construction and may only be partially complete. Please come back soon to see the finished work! (28/06/23)
Introduction[edit | edit source]
Hereditary Neuropathy with Pressure Palsies (HNPP) is a rare type of peripheral neuropathy that affects the peripheral nerves. It is inherited in an autosomal dominant manner meaning individuals have a 50% chance of passing it on to their children. People with HNPP have a higher risk of developing nerve damage when their nerves are exposed to mild pressure or trauma, such as crossing the legs, leaning on the elbows, or wearing tight shoes. This can cause episodes of numbness, tingling, pain, and weakness in the affected areas, which usually last from minutes to months. These episodes are called pressure palsieshb
The cause of HNPP is a mutation in the peripheral myelin protein 22 (PMP22) gene, which is responsible for producing a protein called PMP22. This protein plays a crucial role in the formation and maintenance of myelin, the protective covering around nerve fibers. Unfortunately in HNPP the mutation in the PMP22 gene leads to abnormalities in myelin structure and function resulting in nerve dysfunction.
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