Proliferative Myositis: Difference between revisions

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== Definition/Description  ==
== Definition/Description  ==


Proliferative myositis (PM)&nbsp;is a benign tumor which grows in skeletal muscle<ref name="Fauser et. al">Fauser C, Nahrig J, Niedermeyer H, Arnold W. Proliferative myositis: a rare pseudomalignant tumor of the head and neck. Archives of Otolaryngology - Head &amp;amp;amp; Neck Surgery [serial on the Internet]. (2008, Apr), [cited March 16, 2011]; 134(4): 437-440. Available from: CINAHL with Full Text.</ref>. It is often mistaken for sarcomas (especially rhabdomyosarcoma)<ref name="Meis et. al">Meis J, Enzinger F. Proliferative fasciitis and myositis of childhood. The American Journal Of Surgical Pathology [serial on the Internet]. (1992, Apr), [cited March 16, 2011]; 16(4): 364-372. Available from: MEDLINE.</ref>.&nbsp; While etiology is unknown, it may result from injury to the muscle, fascia, or vasculature (resulting in ischemia) of the associated area<ref name="Dent et. al">Dent C, DeBoom G, Hamlin M. Proliferative myositis of the head and neck. Report of a case and review of the literature. Oral Surgery, Oral Medicine, And Oral Pathology [serial on the Internet]. (1994, Sep), [cited March 16, 2011]; 78(3): 354-358. Available from: MEDLINE.</ref>.&nbsp; Median age of onset is 50 years<ref name="Mulier et. al" />.
Proliferative myositis (PM)&nbsp;is a benign tumor which grows in skeletal muscle<ref name="Fauser et. al">Fauser C, Nahrig J, Niedermeyer H, Arnold W. Proliferative myositis: a rare pseudomalignant tumor of the head and neck. Archives of Otolaryngology - Head &amp;amp;amp;amp; Neck Surgery [serial on the Internet]. (2008, Apr), [cited March 16, 2011]; 134(4): 437-440. Available from: CINAHL with Full Text.</ref>. It is often mistaken for sarcomas (especially rhabdomyosarcoma)<ref name="Meis et. al">Meis J, Enzinger F. Proliferative fasciitis and myositis of childhood. The American Journal Of Surgical Pathology [serial on the Internet]. (1992, Apr), [cited March 16, 2011]; 16(4): 364-372. Available from: MEDLINE.</ref>.&nbsp; While etiology is unknown, it may result from injury to the muscle, fascia, or vasculature (resulting in ischemia) of the associated area<ref name="Dent et. al">Dent C, DeBoom G, Hamlin M. Proliferative myositis of the head and neck. Report of a case and review of the literature. Oral Surgery, Oral Medicine, And Oral Pathology [serial on the Internet]. (1994, Sep), [cited March 16, 2011]; 78(3): 354-358. Available from: MEDLINE.</ref>.&nbsp; Median age of onset is 50 years<ref name="Mulier et. al" />, with rare cases reported in children<ref name="Stanford" />.


== Prevalence  ==
== Prevalence  ==

Revision as of 18:53, 5 April 2011

 

Welcome to PT 635 Pathophysiology of Complex Patient Problems This is a wiki created by and for the students in the School of Physical Therapy at Bellarmine University in Louisville KY. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!

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Definition/Description[edit | edit source]

Proliferative myositis (PM) is a benign tumor which grows in skeletal muscle[1]. It is often mistaken for sarcomas (especially rhabdomyosarcoma)[2].  While etiology is unknown, it may result from injury to the muscle, fascia, or vasculature (resulting in ischemia) of the associated area[3].  Median age of onset is 50 years[4], with rare cases reported in children[5].

Prevalence[edit | edit source]

As of 2008, only about 100 published cases existed, 25% of which dealt with proliferative myositis of the head and neck musculature[1].

Characteristics/Clinical Presentation[edit | edit source]

Signs and symptoms of PM:[1][2][6]

  • Rapidly enlarging, solid tumor within skeletal muscle
  • Localized inflammation
  • No lymph node enlargement
  • No significant laboratory results

Associated Co-morbidities[edit | edit source]

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Medications[edit | edit source]

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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]

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Etiology/Causes[edit | edit source]

While etiology is unknown, PM may result from injury to the muscle, fascia, or vasculature (resulting in ischemia) of the associated area[3]

Systemic Involvement[edit | edit source]

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Medical Management (current best evidence)[edit | edit source]

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Physical Therapy Management (current best evidence)[edit | edit source]

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Alternative/Holistic Management (current best evidence)[edit | edit source]

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Differential Diagnosis[4][2][5][edit | edit source]

  • Myositis Ossificans
  • Neoplasms (especially rhabdomyosarcomas)
  • Proliferative fasciitis
  • Nodular fasciitis
  • Fibromatosis
  • Ganglioneuroblastoma or ganglioneuroma

Case Reports/ Case Studies[edit | edit source]

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Resources
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Recent Related Research (from Pubmed)[edit | edit source]

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References[edit | edit source]

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  1. 1.0 1.1 1.2 Fauser C, Nahrig J, Niedermeyer H, Arnold W. Proliferative myositis: a rare pseudomalignant tumor of the head and neck. Archives of Otolaryngology - Head &amp;amp;amp; Neck Surgery [serial on the Internet]. (2008, Apr), [cited March 16, 2011]; 134(4): 437-440. Available from: CINAHL with Full Text.
  2. 2.0 2.1 2.2 Meis J, Enzinger F. Proliferative fasciitis and myositis of childhood. The American Journal Of Surgical Pathology [serial on the Internet]. (1992, Apr), [cited March 16, 2011]; 16(4): 364-372. Available from: MEDLINE.
  3. 3.0 3.1 Dent C, DeBoom G, Hamlin M. Proliferative myositis of the head and neck. Report of a case and review of the literature. Oral Surgery, Oral Medicine, And Oral Pathology [serial on the Internet]. (1994, Sep), [cited March 16, 2011]; 78(3): 354-358. Available from: MEDLINE.
  4. 4.0 4.1 Mulier S, Stas M, Delabie J, Lateur L, Gysen M, De Wever I, et al. Proliferative myositis in a child. Skeletal Radiology [serial on the Internet]. (1999, Dec), [cited March 16, 2011]; 28(12): 703-709. Available from: MEDLINE.
  5. 5.0 5.1 http://surgpathcriteria.stanford.edu/softfib/proliferative_myositis/printable.html
  6. Gysen M, Stroobants S, Mortelmans L. Proliferative myositis: a case of a pseudomalignant process. Clinical Nuclear Medicine [serial on the Internet]. (1998, Dec), [cited March 16, 2011]; 23(12): 836-838. Available from: MEDLINE.