Muscle Repair: Difference between revisions

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# Destruction phase with the initial inflammatory response  
# Destruction phase with the initial inflammatory response  
# Regeneration phase with activation and proliferation of satellite cells
# Regeneration phase, phagocytosis of damaged tissue, followed by myofibers regeneration, leading to satellite cell activation.
# Remodelling phase with maturation of the regenerated myofibers  
# Remodelling phase, maturation of regenerated myofibers with recovery of muscle functional capacity and also fibrosis and scar tissue formation.<ref>Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)</ref>


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Revision as of 01:58, 1 July 2022

Original Editor - User Name

Top Contributors - Lucinda hampton  

Introduction[edit | edit source]

Skeletal muscle repair requires the activation of satellite cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and extracellular matrix interactions. Immune, fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases

  1. Destruction phase with the initial inflammatory response
  2. Regeneration phase, phagocytosis of damaged tissue, followed by myofibers regeneration, leading to satellite cell activation.
  3. Remodelling phase, maturation of regenerated myofibers with recovery of muscle functional capacity and also fibrosis and scar tissue formation.[1]

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Resources[edit | edit source]

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References[edit | edit source]

  1. Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)