Muscle Repair: Difference between revisions
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# Destruction phase with the initial inflammatory response | # Destruction phase with the initial inflammatory response | ||
# Regeneration phase | # Regeneration phase, phagocytosis of damaged tissue, followed by myofibers regeneration, leading to satellite cell activation. | ||
# Remodelling phase | # Remodelling phase, maturation of regenerated myofibers with recovery of muscle functional capacity and also fibrosis and scar tissue formation.<ref>Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)</ref> | ||
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Revision as of 01:58, 1 July 2022
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Introduction[edit | edit source]
Skeletal muscle repair requires the activation of satellite cells, which are the residential muscle stem cells. The repair/regeneration is a highly coordinated process, involving cell-cell, cell matrix and extracellular matrix interactions. Immune, fibrotic, vascular and myogenic cells all play a role in the three phases of muscle repair/ regeneration. These phases
- Destruction phase with the initial inflammatory response
- Regeneration phase, phagocytosis of damaged tissue, followed by myofibers regeneration, leading to satellite cell activation.
- Remodelling phase, maturation of regenerated myofibers with recovery of muscle functional capacity and also fibrosis and scar tissue formation.[1]
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Resources[edit | edit source]
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References[edit | edit source]
- ↑ Thomas Laumonier and Jacques Menetrey Muscle injuries and strategies for improving their repair Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958098/ (accessed 1.7.2022)