CRISPR Technology: Difference between revisions
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CRISPR is a precision medicine tool that mainly works by finding a specific DNA inside a cell and altering that DNA. CRISPR also works by turning on or off genes without altering their sequence. The system consists of two parts: a '''C'''RISP '''as'''sociated (Cas) nuclease whose role is to connect and cut DNA, and a guide RNA sequense (gRNA) which directs the Cas to its target. <ref name=":0" /> | CRISPR is a precision medicine tool that mainly works by finding a specific DNA inside a cell and altering that DNA. CRISPR also works by turning on or off genes without altering their sequence. The system consists of two parts: a '''C'''RISP '''as'''sociated (Cas) nuclease whose role is to connect and cut DNA, and a guide RNA sequense (gRNA) which directs the Cas to its target. <ref name=":0" /> | ||
Watch this video explaining the CRISPR function: | |||
== Where is CRISPR used? == | == Where is CRISPR used? == | ||
CRISPR is widely used in scientific research but it may be also used in clinical practice. By allowing | CRISPR is widely used in scientific research but it may be also used in clinical practice. By allowing scientists to rewrite genetic code, it can be applied to curing [https://www.physio-pedia.com/Genetic_Conditions_and_Inheritance genetic conditions] such as sickle cell disease and [https://www.physio-pedia.com/Genetic_Conditions_and_Inheritance hereditary disorders] leading to blindness. <ref>Ledford H. [https://pubmed.ncbi.nlm.nih.gov/32157225/ CRISPR treatment inserted directly into the body for the first time]. Nature 2020; 579:185. </ref> | ||
== Relevance to physiotherapy == | == Relevance to physiotherapy == | ||
potential for the study and treatment of intervertebral disc pathologies <ref>Krupkova O., Cambria E., Besse L., Besse A., Bowles R., Wuertz K. [https://pubmed.ncbi.nlm.nih.gov/31463435/ The potential of CRISPR /Cas9 genome editing for the study and treatment of intervertebral disc pathologies]. JOR Spine 2018; 1(1):E1003.</ref> | |||
== Resources == | == Resources == | ||
Revision as of 18:37, 23 June 2022
What is CRISPR?[edit | edit source]
CRISPR is a gene editing technology that originates from a component of bacterial immune systems that can cut DNA like a precise molecular scissors. [1] It stands for Clustered Regularly Interspaced Short Palindromic Repeats.[1]
CRISPR is a precision medicine tool that mainly works by finding a specific DNA inside a cell and altering that DNA. CRISPR also works by turning on or off genes without altering their sequence. The system consists of two parts: a CRISP associated (Cas) nuclease whose role is to connect and cut DNA, and a guide RNA sequense (gRNA) which directs the Cas to its target. [1]
Watch this video explaining the CRISPR function:
Where is CRISPR used?[edit | edit source]
CRISPR is widely used in scientific research but it may be also used in clinical practice. By allowing scientists to rewrite genetic code, it can be applied to curing genetic conditions such as sickle cell disease and hereditary disorders leading to blindness. [2]
Relevance to physiotherapy[edit | edit source]
potential for the study and treatment of intervertebral disc pathologies [3]
Resources[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 1.2 Synthego. The ultimate guide to CRISPR: Mechanism, applications, methods & more. Available from: https://www.synthego.com/learn/crispr (accessed 22/6/2022)
- ↑ Ledford H. CRISPR treatment inserted directly into the body for the first time. Nature 2020; 579:185.
- ↑ Krupkova O., Cambria E., Besse L., Besse A., Bowles R., Wuertz K. The potential of CRISPR /Cas9 genome editing for the study and treatment of intervertebral disc pathologies. JOR Spine 2018; 1(1):E1003.
