Ewing's Sarcoma: Difference between revisions
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== Associated Co-morbidities == | == Associated Co-morbidities == | ||
Pathological Fractures secondary to osteomalacia. | |||
== Medications == | == Medications == |
Revision as of 20:42, 16 March 2011
Original Editors - Lisa Miville from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Lead Editors - Your name will be added here if you are a lead editor on this page. Read more.
Definition/Description[edit | edit source]
Ewing’s Sarcoma is a high grade malignant primary tumor that can arise in soft tissue or bone. It is often referred to as a family of tumors known as Ewing family of tumors (EFT).1-4 The tumor is named after James Ewing who first discovered the small, blue round cell that was distinct from osteogenic sarcoma.4 Although any bone can be invovled, the most common are the pelvis, femur, tibia, ulna and metatarsals.7 Close behind is the ribs and vertebral column.3 EFT is most common in children between the ages of 5 and 16, and due to recent availability of multi-agent cytostatic approaches and local therapy, the 5 year survival rate has increased from 10% to 70%.4,6 Prognosis is dependent on metastisis, worsening with widespread involvement. 26% of patients with EFT have metatstic disease: 10% to the lungs, 10% to bone/bone marrow, and 6% combination.3
Prevelance[edit | edit source]
Ewing's Sarcoma is the second most common primary malignant bone tumor of children and the fourth more common overall. 80% of these tumors occur in people under the age of 20 and they have been reported in children as young as 5 months. They rarely occur in the African American or Asian population.1,2 EFT is more common in males than females 1.5:1.1,3,4,6,8
Characteristics/Clinical Presentation[edit | edit source]
Pain at the affected site is usually the intial symptom.4 The pain may be worse during exercise or at night and can be accompanied by swelling and warmth.5 The clinical presentation can be similar to that of osteosarcoma, but Ewing's pain is usually intermeittent.7 The tumor may be present for months before there are any signs or symptoms. An injury is often what brings attention to the tumor, because bone weakened by disease can break with little force. Kids with EFT can go undiagnosed until an injury from a sport or rough requires diagnostic imaging.9
Associated Co-morbidities[edit | edit source]
Pathological Fractures secondary to osteomalacia.
Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
Chemotherapy, radiation, surgical resection, limb salvage, amputation.1,2
Etiology/Causes[edit | edit source]
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Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Alternative/Holistic Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
Osteomyelitis - swelling, redness, low grade fever and flu-like symptoms may be present in both conditions.
Case Reports/ Case Studies[edit | edit source]
add links to case studies here (case studies should be added on new pages using the case study template)
Resources
[edit | edit source]
1. Pathophysiology book
2. MedlinePlus
3. UK guidelines
4. Ewing Tumor, INcidence, prognosis and treatment
5.Kids health.org
6. Goodman C, Snyder T. Differential Diagnosis for Physical Therapists: Screening for Referral. St. Louis, MO: Saunders Elsevier: 2007
7. Powerpoint from complex patient
8. ewing's sarcoma ann o. karosas
9. AAOS Ewings
Recent Related Research (from Pubmed)[edit | edit source]
see tutorial on Adding PubMed Feed
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References[edit | edit source]
see adding references tutorial.