Peripheral Sensitisation

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• Describe the physiological processes underlying peripheral sensitisation
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Peripheral Sensitization:
After a peripheral nerve lesion, aberrant regeneration may occur. Neurons become unusually sensitive and develop spontaneous pathological activity, abnormal excitability, and heightened sensitivity to chemical, thermal and mechanical stimuli. This phenomenon is called "peripheral sensitization".
Peripheral sensitization occurs because of
- Sensitization of peripheral neurons
- Collateral sprouting of A fibers
- Increased activity of damaged axons and their sprouts
It is categorized under spontaneous sensations, sympathetic maintained pain. There is sustained burning pain associated with vasomotor, sudomotor and trophic changes on skin.

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