Neurogenic Inflammation
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Introduction[edit | edit source]
Neurogenic inflammation (NI) is a physiological process in which mediators are released directly from the cutaneous nerves to initiate an inflammatory reaction in response to tissue damage or a painful stimuli. This results in the production of local inflammatory responses including erythema, swelling, temperature increase, tenderness, and pain.
Neurogenic inflammation has also been implicated in the pathophysiology of numerous diseases, including complex regional pain syndrome, migraine, and irritable bowel, arthritis, bladder inflammation, asthma and bladder syndromes. However, in the setting of wound healing, neurogenic inflammation helps maintain tissue integrity and facilitate tissue repair.[1]
Mechanism of Injury[edit | edit source]
Neurogenic inflammation is initiated by activation of peripheral nervous system C-fibre neurons causing a release of neuropeptides, such as substance P and calcitonin gene-related peptide (CGRP), which triggers inflammation at the site that is different from the original stimuli. Many different chemicals, including formaldehyde, ether, and cigarette smoke, can exert an irritant effect by stimulating these c-fibers in humans[1].
Post Stroke Depression[edit | edit source]
Post Stroke Depression (PSD) is one of the most common mood disorders with depressive consequences in stroke patients[2]. PSD affects approximately one-third of stroke patients, and thus may cause a reduction in quality of life and life expectancy through multiple factors such as: cognitive decline, increased risk of falls, high suicidal rate, functional impairment, stagnated recovery process and poor response to rehabilitation [3][4].
Management / Interventions[edit | edit source]
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Resources[edit | edit source]
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References[edit | edit source]
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- ↑ 1.0 1.1 Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation – the peripheral nervous system’s role in host defense and immunopathology. Nat Neurosci. 2012;15:1063-1067.
- ↑ (Robinson RG and Jorge RE: Post-stroke depression: A review. Am J Psychiatry. 173:221–231. 2016.PubMed/NCBI View Article : Google Scholar).
- ↑ Paolucci S, Iosa M, Coiro P, Venturiero V, Savo A, De Angelis D and Morone G: Post-stroke depression increases disability more than 15% in ischemic stroke survivors: A case-control study. Front Neurol. 10(926)2019.PubMed/NCBI View Article : Google Scholar
- ↑ Robinson RG and Jorge RE: Post-stroke depression: A review. Am J Psychiatry. 173:221–231. 2016.PubMed/NCBI View Article : Google Schola
