Introduction to Benign Paroxysmal Positional Vertigo

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Original Editor - Bernard Tonks Top Contributors - Jess Bell, Kim Jackson, Tarina van der Stockt, Rucha Gadgil, Lucinda hampton and Robin Tacchetti

Introduction

Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo that arises from a peripheral vestibular disorder. It accounts for 20 to 30 percent of all patients seen for vertigo in clinics that specialise in dizziness.

While the overall incidence of BPPV in the general population is around 2.5 percent, it is more common in older adults. Some studies show that 50 percent of older adults have BPPV.

Symptoms tend to be provoked by head movements, such as:

• Looking up
• Lying down flat quickly
• Bending forwards
• Rolling in bed

BPPV is a biomechanical problem in which one or more of the semicircular canals is inappropriately excited, resulting in vertigo, nystagmus and occasionally nausea. It occurs when there is displacement of calcium-carbonate crystals or otoconia from the utricle into one of the three fluid-filled semicircular canals of the inner ear. For more information on the anatomy of the vestibular system, please click here.

Aetiology

It is not yet known what causes BPPV. The majority of cases are idiopathic, but it is more likely to recur in older adults.

The two primary theories about its aetiology are that it is:

1. Related to ischaemia and cardiovascular disease
2. Related to vitamin D deficiency and calcium metabolism (seasonal variations may be present)

Predisposing factors include:

• Head trauma in all age groups
  • In a younger population head trauma is a leading predisposing factor
• The recurrence rate may be higher and treatment may not be as effective in a head trauma population
• Surgical trauma to the inner ear
• Vestibular labyrinthitis / neuritis
• Migraines
• Ischaemia of the anterior vestibular artery and cardiovascular disease

The majority of BPPV occurs in the posterior canals  (85 to 95 percent). 5 to 15 percent occurs in the horizontal canals and 1 to 5 percent occurs in the anterior canals.

Variants of BPPV

Two variants of BPPV can be present:

1. Cupulolithiasis
2. Canalithiasis

Cupulolithiasis (i.e. ‘stuck crystals’)

• The debris adheres to the cupula of the affected canal, causing the cupula to be gravity sensitive
• Changes in head position cause an inappropriate deflection of the cupula resulting in nystagmus, vertigo, and nausea
• This is a relatively uncommon form of BPPV

Canalithiasis (‘free floating crystals’)

• This theory better explains the typical characteristics of BPPV
• Otoconia are floating freely within the endolymph of the SCC
• When the head is moved into the plane of the affected canal, the debris moves into the most dependent portion causing movement of the endolymph which deflects the cupula producing vertigo, nystagmus and nausea

The key characteristics of these two variants of BPPV are summarised in Table 1.

Table 1. Characteristics of BPPV variants.

	Canalithiasis	Cupulolithiasis
Latency of onset	>1 second before the onset of vertigo and nystagmus	No latency
Duration	Vertigo and nystagmus lasts < 60 seconds	Vertigo and nystagmus persist > 1minute
Direction of nystagmus	Characteristic nystagmus depending on which canal is involved	Characteristic nystagmus depending on which canal is involved
Fatigability	Decreased intensity of vertigo and nystagmus with repeated movement of the patient in provoking positions	Decreased intensity of vertigo and nystagmus with repeated movement of the patient in provoking positions

Assessment

Assessing the Vertical Canals

Dix-Hallpike Test

The Dix-Hallpike (DH) test is used to assess BPPV (primarily the vertical canals). This test enables the therapist to identify the side of the lesion and frequently the specific canal involved.

• Patient is seated with their head turned 45 degrees toward the test side
• Patient is moved as rapidly (safely) as possible into a supine position with the head extended 20 degrees
• Have the patient look at your nose and observe his / her eyes for nystagmus - note the direction of the movement, latency, and duration of nystagmus (see Table 2)
• Wait until the nystagmus stops and then typically proceed into treatment (see below) if indicated (some therapists will slowly sit the patient up in order to assess the other side, but nausea can be a problem)
• Depending on results, repeat on the other side

Kaplan and colleagues have found that shaking the head during the DH increases the diagnostic yield. Patients who have a negative DH, but positive result with head shaking may have a milder form of BPPV.

If BPPV is likely present, but the DH is negative, this test can be repeated a couple of times to ensure that it is negative (“sticky canalithiasis”).

It is important to try to assess the unaffected side first if possible. You can reason which side this might be based on the patient’s subjective report - i.e. the side she / he does not like to lie on. However, often the patient will not be able to tell you which side is worse.

Side Lying Test

• Patient is seated with head turned 45 degrees away from the side to be tested
• Patient is moved quickly into side lying on the side opposite to the side that the head is turned
• Observe eyes for nystagmus
• Repeat the test with the head turned to the other side

This test is a valid alternative test that can be used when the DH is not considered a viable option (e.g. if there are range of motion limitations).

Assessing the Horizontal Canals

Head Roll Test

The head roll test can be used to assess the horizontal canals as it places these canals in the plane of gravity. It is considered a positive test when:

• Horizontal nystagmus is provoked (see Table 2)
• The patient reports vertigo when rolling to both the right and left sides

The patient is initially positioned in supine with his / her head in a neutral position. The therapist quickly rotates the patient’s head 90 degrees to one side, checking for nystagmus.

To perform the test:

1. Patient lies supine with the head elevated 20 degrees on a pillow

1. Roll the head quickly to the one side (can do whole body rolls)

1. Observe the patient’s eyes for nystagmus and note the direction, latency, and duration. Watch for direction changing nystagmus

1. Bring the patient’s head back to the neutral position in supine and wait until his / her signs and symptoms settle. Then roll the head quickly to the other side and observe

1. Both side lying positions will be positive for vertigo and nystagmus (same pattern) in horizontal semi-circular canal BPPV

There are two types of nystagmus associated with the horizontal canals and they can be used to differentiate between cupulolithiasis and canalithiasis: 

• Geotropic (quick phase towards the earth)
  • Associated with canalithiasis
    • Will have latency before onset and be shorter in duration
  • If geotropic nystagmus is provoked, assume that the most symptomatic side is the affected side and treat this side
• Ageotropic (quick phase towards the ceiling)
  • Associated with cupulolithiasis
    • Will have immediate onset and prolonged duration
  • If ageotropic nystagmus is provoked, assume the less symptomatic side is the affected side and treat this side

Table 2. Identification of canal involvement - nystagmus

Involved Canal	Dix-Hallpike (DH) and Head Roll Test
Right posterior Right DH	Up beating, right torsion
Right anterior Left DH	Down beating, right torsion
Left anterior Right DH	Down beating, left torsion
Left posterior Left DH	Up beating, left torsion
Right / left horizontal canals Head roll test	Horizontal nystagmus, no torsion

Distinguishing Between a Central Nervous System Lesion and BPPV

Lesions of central origin often present with: 

• Atypical nystagmus (sustained downbeating, no torsion)
• No fatiguability of the response with repeated testing
• No decrease in the nystagmus +/- vertigo with prolonged DH position
• No reversal phenomenon (reversal of nystagmus)

See Table 3 for a summary of the key features that distinguish central and peripheral lesions.

	Central	Peripheral
		Cupulolithiasis	Canalithiasis
Latency	No	No	Yes (>1 second)
Duration	Persistent	1-2 minutes	< 60 seconds
Direction	Uniplanar	Multiplanar	Multiplanar
Fatiguability	No	Yes	Yes

Table 3. Distinguishing central nervous system lesion and BPPV

Treatment

Vertical Canal Canalithiasis

Epley Manoeuvre

The Epley manoeuvre (also known as canalith repositioning treatment) is used to treat posterior and anterior canal canalithiasis.

The manoeuvre is performed as follows:

1. The patient is moved into DH on his / her affected side
2. The therapist rotates the patient’s head through 90 degrees to the opposite side; maintaining 30 degrees of extension
3. The patient is rolled onto the unaffected side with his / her head looking down
4. Maintaining head rotation, the patient gently sits up at side of bed

Gans Manoeuvre

The Gans manoeuvre is a modified Epley manoeuvre. It is performed as follows (assuming the right side is affected:

1. Patient is positioned in side lying test position - i.e. sitting.
2. Patient turns head 45 degrees to the left
3. Patient lies down quickly onto his / her right side (no pillow), and holds this position for 2-3 minutes until the vertigo / nystagmus resolves
4. The patient then rolls over onto his / her left side, while maintaining the same head position
5. Wait 2-3 minutes as above
6. The patient sits up to complete the manoeuvre

Because the Gans manoeuvre starts in the side lying test position, this treatment may be more advantageous for some patients.

Efficacy of Treatment for Vertical Canal BPPV

The Epley Manoeuvre

The Epley manoeuvre is a safe and effective treatment for posterior canal BPPV. It has no serious side effects, but there is no evidence that it provides long-term resolution of symptoms and recurrence rates are high. The Gans manoeuvre has been shown to have similar outcomes as the Epley.

• 93.5 percent of patients treated with an Epley manoeuvre had positive responses compared to 50 percent of the control group
• Macias and colleagues looked at 259 BPPV patients who received the Epley manoeuvre:
  • 74.8 percent required  only one treatment
  • 19 percent required two treatments
  • 98.4 percent of patients were successfully treated after three sessions

Epley manoeuvre head positions in patients with posterior canal BPPV:

• During an Epley manoeuvre, if the patient was returned to a sitting position without rolling over onto his / her side with the head down at 45 degrees, the remission rate was found to be 50 percent
• This suggests that the last component of the Epley manoeuvre facilitates the movement of the debris into the common crus

Gans Manoeuvre

The Gans manoeuvre was developed because certain aspects of other BPPV manoeuvres, such as hyperextension of the neck during the Epley, are contraindicated for patients with vertebrobasilar insufficiency, cervical spondylosis, back problems etc. Roberts and colleagues assessed the efficacy of the Gans manoeuvre and found that:

• On average, 1.25 treatments were needed to resolve the posterior semi-circular canal BPPV
• Most patients (80.2%) were cleared with one treatment
• 95.6 percent were cleared after two treatments
• The Gans is, therefore, a good option for patients who cannot have the Epley or liberatory manoeuvres (see below) because of various contraindications (e.g. VBI, back, hip and / or mobility issues)

Horizontal Canal Canalithiasis Treatment

There are two key treatments for horizontal canal canalithiasis:

1. Forced prolonged positioning (i.e. 8 to 12 hours) lying on the unaffected side
2. Barbecue roll (also known as the Lempert roll)

Barbecue Roll

To perform this canalith repositioning treatment:

1. The patient is positioned in supine with his / her head elevated 20 degrees and turned toward the affected side
2. The therapist slowly rolls the patient’s head away from the affected side in 90 degree increments until the head has moved through 360 degrees
3. Each position is maintained until the vertigo has stopped or for 15 seconds
4. The patient should have no vertigo or nystagmus once they are prone

NB usually whole body rolls are performed instead of just neck rotations

Efficacy of Treatment for Horizontal Canal Canalithiasis

Nuti and colleagues compared two different treatments for horizontal canal canalithiasis versus an untreated control group.

• Barbecue roll – patients were rotated around the longitudinal axis in 90 degree stages
• Prolonged positioning – patients lay on the uninvolved side for prolonged periods

Both treatments had similar remission rates:

• 71 percent in the rolling group
• 73 percent in the forced prolonged positioning treatment
• 33 percent in the control group

A more recent study by Wang and colleagues also supports the use of the barbecue roll.

Vertical Canal Cupulolithiasis

Liberatory (Semont) Manoeuvre

The liberatory (semont) manoeuvre is used to treat posterior canal BPPV. To perform this manoeuvre:

• The patient is sitting with legs over the side of the bed
• Turn his / her head 45 degrees toward the unaffected side
• Therapist quickly moves the patient into side-lying on the affected side
• Hold for 5 minutes
• Quickly, move the patient all the way back up and then down to the opposite side-lying position, maintaining his / her head position
• Hold for 5 minutes
• In this second position, nystagmus and vertigo typically appear.  If they do not, the head is abruptly shaken once or twice to free the debris
• Slowly sit the patient up

To treat anterior canal BPPV with the liberatory (semont) manoeuvre, the manoeuvre is similar, but the patient’s head is turned to the affected side to begin:

• Patient sits with legs over the side of the bed
• Turn his / her head 45 degrees toward the affected side and quickly move the patient into side-lying on the affected side - essentially, the patient is lying on his / her affected canal
• Hold for 5 minutes
• Quickly, move the patient all the way back up and then down to the opposite side-lying position, maintaining his / her head position
• Hold for 5 minutes
• In this second position, nystagmus and vertigo typically appear.  If they do not, the patient’s head is abruptly shaken once or twice to free the debris
• Slowly sit the patient up

Efficacy of the Liberatory Manoeuvre

Semont and colleagues found that in 711 patients with BPPV, treated over an 8-year period, there was complete remission in 84 percent of patients after one treatment and 93 percent after a second procedure one week later.

Salvinilli and colleagues also found that the liberatory manoeuvre had good results. They found there was a remission rate of 92.5 percent with one manoeuvre while the untreated control group had a remission rate of 37.5 percent.

Horizontal Canal Cupulolithiasis

The modified semont manoeuvre can be used to treat horizontal canal cupulolithiasis. It is performed as follows:

• Start with the patient sitting on a bed. Lie him / her quickly down into side-lying on the affected side (i.e. the less symptomatic side to the patient)
• Immediately at this point, a 45 degree rotation downward is conducted
• Hold for 2 to 3 minutes
• Then return the patient quickly to the sitting position

This modified semont manoeuvre resulted in resolution of symptoms for 77.7 percent of patients with horizontal canal cupulolithiasis after three sessions.

Brandt-Daroff Treatment: Home exercise program for BPPV

To perform these exercise programme, patients are instructed to:

• Turn their head 45º away from the affected side and lie quickly onto the affected side
• Hold this position until vertigo stops (+ 30 seconds)
• Then return to sitting position and hold for 30 seconds or until the vertigo stops
• Repeat these steps on the opposite side
• Repeat this sequence 10-20 times, three times per day

NB patients can stop exercise if you have 2 consecutive days with no symptoms or if there has been no improvement within 2 weeks.

Effectiveness of the Brandt-Daroff Exercises

Brandt and Daroff studied the effectiveness of these exercises on a series of 67 patients with BPPV. They found that after 3 to 14 days of exercises, 98% of the subjects had no symptoms of BPPV. More recent studies have also found these exercises to be effective.

Clinically, however, this exercise programme often requires a prolonged period of time for patients to experience an improvement in their symptoms.

Relevance of Postural Restrictions for BPPV

Postural restrictions post-Epley manoeuvre did not improve the efficacy of treatment or diminish the recurrence rate. There are, therefore, no restrictions placed on patients after an Epley manoeuvre at this time.

Daily Epley Manoeuvres and BPPV

A daily routine of the self-CRP does not affect the time to recurrence or the rate of recurrence of posterior canal BPPV. Patients should not, therefore, do the Epley maneuver as a home exercise to prevent recurrence of BPPV.

Sleep Position and Laterality of BPPV

There is an association between the ear affected by BPPV and the preferred head-lying side during sleep onset. It has been found that there are higher recurrence rates in patients who sleep on their affected side.

Patients may, therefore, want to change or vary the side they sleep on sleep on if BPPV is recurring.

Canal conversion

During treatment of posterior semi-circular canal BPPV, debris moves from the posterior canal to the horizontal canal (usually) or to the anterior canal (rarely – 2.9%).

This is clear when a DH retest results in dramatically different nystagmus patterns after the Epley manoeuvre has been performed. If this occurs, it is necessary to re-evaluate and treat the newly involved canal. The Epley manoeuvre may have a higher rate of conversion than the Semont.

Where do the otoconia go?

There are various theories proposed to explain where the otoconia go:

• Parker suggests they just dissolve 1968
• Lim suggested that the ‘dark cells’ of the labyrinth, which are adjacent to the utricle and crista reabsorb the displaced otoconia LIM 1984 NEED REF
• Otsuka suggests they stick back to the utricle OTUSKA 2010 NEED REF

Management issues in BPPV

• BPPV is frequently considered a self-limiting disorder as the spontaneous remission rate can be as high as 50 percent
• However, for many individuals it persists for years if not decades
• Recurrence rate varies from 18 to 37 percent
• Antivertiginous drugs are not helpful
• Some patients may experience increased dizziness, nausea and imbalance for a day or two after treatment – possibly due to an autonomic dysfunction KIM 2014 -  NEED REF
• It is important to bring the patient back for re-evaluation, usually in 3 to 5 days if possible
• Evaluate postural control, vestibular function and motion sensitivity
• If the patient has a vestibular hypofunction and BPPV, treat the BPPV first
• Be alert to central signs and symptoms