Hypercalcemia Case Study

Author/s

Shawn Maskalick, Chinwe Okoro, Logan Simcox, Ali Hasnie

Bellarmine University

Doctor of Physical Therapy Program

Class of 2016

Abstract - Hypercalcemia Characteristics

Hypercalcemia is characterized as greater than normal amounts of calcium in the blood.  Symptoms can effect the musculoskeletal, nervous, cardiovascular/pulmonary, and gastrointestinal systems (see table below). Normal serum calcium levels range between 8.2 and 10.2 mg/dL.  Mild hypercalcemia is considered when calcium levels are around 12 mg/dL and severe hypercalcium is defined as serum calcium levels at 14 mg/dL.

System	Symptoms
Central Nervous System (CNS)	drowsiness, lethargy, coma irritability, personality changes, confusion, headaches, depression, memory loss, difficulty concentrating, visual disturbances, balance/coordination problems, changes in deep tendon reflexes, change in muscle tone for individual with neurologic condition, positive Babinski and/or clonus reflex, changes in bowel/bladder function
Musculoskeletal	muscle pain or tenderness and weakness, muscle spasms, bone pain (worse at night and on weight bearing), pathologic fracture
Cardiovascular	Hypertension, Arrhythmia, Cardiac arrest
Gastrointestinal	Anorexia (loss of appetite), nausea, vomiting, constipation, dehydration, thirst

In the case described below, hypercalcemia occured secondary due to Vitamin D intoxication.

Patient Characteristics

• 65 year old
• White female
• Height: 5' 8"  Weight:165
• Retired administrative assistant
• Runs a soup kitchen 3 days/week
• Diagnosis:  Hypercalcemia secondary to Vitamin D intoxication & thiazide diuretic
  
• Past Medical History:  Primary hypothyroidism, HTN, hyperlipidemia, & vitamin D deficiency

Examination

• Subjective: Chief Complaint:fatigue, anorexia, nausea, abdominal pain, constipation and depression for 1 month. 
• Objective :She appears weak and dry. Vitals: BP: 154/92  RHR:  84 bpm  Heart Sounds: audible S1,S2. Lungs were clear to ascultate bilaterally. Alert & oriented x 1 (only person).  Oxygen saturation:  95% on room air

ROM (UE's):  WNL  

ROM (LE's):  WNL  

Gross MMT:  UE: EROT: 4/5 bilaterally, Elbow flexion: 4/5 left, 5/5 right, elbow extension: 4/5,  Shoulders, wrists, & grip strength: 5/5 bilaterally.   LE: Hip Abduction: 4/5 bilaterally, knee extension: 4/5 on the left & 5/5 on the right, hip flexion, knee flexion, plantar flexion & dorsiflexion 5/5 bilaterally.  

Reflexes:  Normal  

Sensation: Normal  

Posture: elevated/protracted shoulders, forward head position  

Gait:  limited bilateral hip extension, decreased bilateral reciprocal arm swing, shortened step length  

Static sitting:  normal

Dynamic sitting:  normal  

Bed mobility: Independent  

Sit to stand: independent  

Bed to Chair & Chair to Bed transfer: Independent  

Ambulation:  150 feet with contact guard assist    

Basic metabolic panel: hypercalcemia 13mg/dl, ionized calcium of 1.8, acute kidney injury with Cr of 2.2 & hyperphoshatemia.  Further lab data showed a low PTH & high Vit D levels.

• Self Report/Physical Performance:  Visual Analog Scale (VAS) Best: 4/10  Current: 7/10  Worst: 9/10    6 Minute Walk Test - 375 meters 
  
  

Clinical Impression

1) Hypercalcemia & Hyperphosphotemia secondary to Vit D intoxication & thiazide diuretic
2) Acute Kidney injury secondary to Hypercalcemia
3) Dehydration secondary to Hypercalcemia

Summarization of Examination Findings

Based on the subjective and objective findings, the targeted intervention was to rehydrate with normal saline (IVF).  In a case of severe hypercalcemia, intervention would include the administration of biphosphonate or calcitonin.  The goal for restoration of function of this patient is to rehydrate the patient with normal saline in order to excrete calcium from the renal tubules. It's important to determine the etiology of the hypercalcemia (PTH related on non-PTH related) as the management may vary. Our case is non-PTH related hypercalcemia due to Vit D intoxication.

Discussion

Summary Statement which should include related findings in the literature, potential impact on clinical practices

Related Pages

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References:

1.  Schroth M, Dötsch J, Dörr H. Hypercalcemia and idiopathic hypoparathyroidism. Journal Of Clinical Pharmacy & Therapeutics [serial online]. December 2001;26(6):453-455. Available from: CINAHL with Full Text, Ipswich, MA. Accessed March 27, 2015.

2.  Chih-Jen C, Chung-Hsing C, Shih-Hua L. An Unrecognized Cause of Recurrent Hypercalcemia: Immobilization. Southern Medical Journal [serial online]. April 2006;99(4):371-374. Available from: Academic Search Complete, Ipswich, MA. Accessed March 27, 2015.

3.  Oghazian, M., Ataei, S., Radfar, M.. Vitamin D Intoxication with Hypercalcemia Due to Overuse of Supplement. Journal of Pharmaceutical Care, Tehran, Iran, 1, Sep. 2013. Available at: <http://jpc.tums.ac.ir/index.php/jpc/article/view/58>. Date accessed: 27 Mar. 2015.

4. Goodman, Catherine Cavallaro, and Snyder, Teresa E. Kelly. Differential Diagnosis for Physical Therapists: Screening for Referral. 5th ed. St. Louis, MO: Saunders/Elsevier, 2013. Print.