Grades and Levels of Evidence: Difference between revisions

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== Levels of Evidence  ==
== Levels of Evidence  ==


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{| cellspacing="1" cellpadding="1" border="1" style="width: 638px; height: 243px;"
{| cellspacing="1" cellpadding="1" border="1" style="width: 711px; height: 274px;"
|+ Produced by Bob Phillips, Chris Ball, Dave Sackett, Doug Badenoch, Sharon Straus, Brian Haynes, Martin Dawes since November 1998.
|+ Produced by Bob Phillips, Chris Ball, Dave Sackett, Doug Badenoch, Sharon Straus, Brian Haynes, Martin Dawes since November 1998.  
|-
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| '''<u>Level<br></u>'''
| '''<u>Level<br></u>'''  
| <u>'''Therapy/Prevetion, Aetiology/Harm'''</u>'''<br>'''
| <u>'''Therapy/Prevetion, Aetiology/Harm'''</u>'''<br>'''  
| <u>'''Prognosis'''</u><br>
| <u>'''Prognosis'''</u><br>  
| <u>'''Diagnosis'''</u><br>
| <u>'''Diagnosis'''</u><br>  
| <u>'''Differential Diagnosis'''</u><br>
| <u>'''Differential Diagnosis'''</u><br>  
| <u>'''Economic and Descision Analysis'''</u><br>
| <u>'''Economic and Descision Analysis'''</u><br>
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|-
| 1A<br>
| '''1A'''<br>  
| SR (with homogeneity) of RCTs <br>
| SR (with homogeneity) of RCTs <br>  
| SR (with homogeneity) of inception cohort studies; <br>
| SR (with homogeneity) of inception cohort studies; CDR validated in different populations<br>  
| SR (with homogeneity) of Level 1 diagnostic studies;<br>
| SR (with homogeneity) of Level 1 diagnostic studies; CDR with 1b studies from different clinical centres<br>  
| SR (with homogeneity) of prospective cohort studies <br>
| SR (with homogeneity) of prospective cohort studies <br>  
| SR (with homogeneity) of Level 1 economic studies<br>
| SR (with homogeneity) of Level 1 economic studies<br>
|-
|-
| 1B<br>
| '''1B'''<br>  
| <br>
| Individual RCT (with narrow Confidence Interval)<br><br>  
| <br>
| Individual inception cohort study with &gt; 80% follow-up; CDR validated in a single population<br>  
| <br>
| Validating cohort study with good reference standards; or CDR tested within one clinical centre<br><br>  
| <br>
| Prospective cohort study with good follow-up<br>  
| <br>
| Analysis based on clinically sensible costs or alternatives; systematic review(s) of the evidence; and including multi-way sensitivity analyses<br>
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| 1C<br>
| 1C<br>  
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| 2A<br>
| 2A<br>  
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| 2B<br>
| 2B<br>  
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| 2C<br>
| 2C<br>  
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|-
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| 3A<br>
| 3A<br>  
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| 3B<br>
| 3B<br>  
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| 4<br>
| 4<br>  
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| 5<br>
| 5<br>  
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Revision as of 16:27, 8 June 2009

Original Editor - Tyler Shultz

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Discussion & Background[edit | edit source]

Levels of Evidence[edit | edit source]


Produced by Bob Phillips, Chris Ball, Dave Sackett, Doug Badenoch, Sharon Straus, Brian Haynes, Martin Dawes since November 1998.
Level
 		Therapy/Prevetion, Aetiology/Harm
 		Prognosis
 Diagnosis
 Differential Diagnosis
 Economic and Descision Analysis
1A
 SR (with homogeneity) of RCTs
SR (with homogeneity) of inception cohort studies; CDR validated in different populations
 SR (with homogeneity) of Level 1 diagnostic studies; CDR with 1b studies from different clinical centres
 SR (with homogeneity) of prospective cohort studies
SR (with homogeneity) of Level 1 economic studies
1B
 Individual RCT (with narrow Confidence Interval)

 Individual inception cohort study with > 80% follow-up; CDR validated in a single population
 Validating cohort study with good reference standards; or CDR tested within one clinical centre

 Prospective cohort study with good follow-up
 Analysis based on clinically sensible costs or alternatives; systematic review(s) of the evidence; and including multi-way sensitivity analyses
1C




2A




2B




2C




3A




3B




4




5




Grades of Evidence[edit | edit source]

Recent Related Research (from Pubmed)[edit | edit source]

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References[edit | edit source]



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