Biofilms Role in Chronic Infections

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Original Editor - Lucinda hampton Top Contributors - Lucinda hampton, Vidya Acharya, Admin, Kim Jackson and Nupur Smit Shah

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Top Contributors - Lucinda hampton, Vidya Acharya, Admin, Kim Jackson and Nupur Smit Shah  

Introduction[edit | edit source]

A biofilm is an architectural colony of microorganisms, within a matrix of extracellular polymeric substance that they produce. Biofilm contains microbial cells adherent to one-another and to a static surface (living or non-living). Bacterial biofilms are usually pathogenic in nature and can cause hospital infections. The National Institutes of Health (NIH) revealed that among all microbial and chronic infections, 65% and 80%, respectively, are associated with biofilm formation[1].

A common misconception of microbial life is that bacteria exist as individual organisms in a ‘planktonic state’. However microorganisms have been shown to naturally accumulate on a wide variety of surfaces; where they form sessile, sedentary communities. Those surfaces include biomaterials such as contact lenses, medical devices including implants and urinary catheters[2]. Bacterial contamination on implants and prosthetic medical devices causing infections can be life-threatening, leading to device failure, chronic infections and high mortality and morbidity rates[3].

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References[edit | edit source]

  1. ↑ Jamal M, Ahmad W, Andleeb S, Jalil F, Imran M, Nawaz MA, Hussain T, Ali M, Rafiq M, Kamil MA. Bacterial biofilm and associated infections. Journal of the Chinese Medical Association. 2018 Jan 1;81(1):7-11. Available from: https://www.sciencedirect.com/science/article/pii/S1726490117302587 (last accessed 7.10.2019)
  2. ↑ British Society for Immunology Biofilms and their role in pathogenesis Available from: https://www.immunology.org/public-information/bitesized-immunology/pathogens-and-disease/biofilms-and-their-role-in (last accessed 7.10.19)
  3. ↑ Khatoon Z, McTiernan CD, Suuronen EJ, Mah TF, Alarcon EI. Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention. Heliyon. 2018 Dec 1;4(12):e01067. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312881/ (last accessed 7.10.19)
  4. ↑ biofilm What Are Bacterial Biofilms? A Six Minute Montage Available from: https://www.youtube.com/watch?v=lpI4WCM_9pM (last accessed 7.10.19)
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