Atypical Presentation of Covid in the Elderly: Difference between revisions

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== Introduction ==
== Introduction ==
The COVID-19 pandemic shows how vulnerable elderly persons are and that the low capacity of the immune system leads to a fatal outcome. Quick implementation of preventive and therapeutic strategies was not possible due to the worldwide nature of COVID.   Protection of those at risk who already carried the load of other health issues was limited.
The [[COVID-19]] pandemic shows how vulnerable [[Older People Introduction|elderly persons]] are and that the low capacity of the [[Immune System|immune system]] leads to a fatal outcome. Quick implementation of preventive and therapeutic strategies was not possible due to the worldwide nature of COVID.   Protection of those at risk who already carried the load of other health issues was limited.


== COVID in the Elderly ==
== COVID in the Elderly ==
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiology of a new type of viral pneumonia, the Corona Virus Disease 19 (COVID-19).<ref name=":0">Bencivenga L, Rengo G, Varricchi G. [https://link.springer.com/article/10.1007/s11357-020-00218-9 Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition]. GeroScience 2020, 42; 1089–1092. </ref> It affects people of all ages everywhere in the world, but a majority of deaths from this disease occur in the elderly. The study shows that in the group of individuals 65 years and older, the most susceptible are those suffering two or more comorbidities. Furthermore elderly with a history of [[Cardiovascular Disease|cardiovascular disease]], [[Diabetes|diabetes mellitus]], [[Chronic Obstructive Pulmonary Disease Rehabilitation Class|chronic obstructive pulmonary disease]], malignancy and chronic kidney disease are the most at risk of dying from [[Coronavirus Disease (COVID-19)|COVID.]]<ref>Emami A, Javanmardi F, Pirbonyeh N, Akbari A. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096724/ Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis]. Arch Acad Emerg Med. 2020 Mar 24;8(1):e35.  </ref> Additional factors include disabilities, [[Cognitive Deficits|cognitive]] and mood disorders, polypharmacotherapy, social isolation, and [[COVID-19 and Nutrition|nutritional deficits]] often present in the residents of long-term care facilities.<ref name=":1">Leij-Halfwerk S, Verwijs MH, van Houdt S, Borkent JW, Guaitoli PR, Pelgrim T, Heymans MW, Power L, Visser M, Corish CA, de van der Schueren MAE; MaNuEL Consortium. [https://www.maturitas.org/article/S0378-5122(19)30114-8/fulltext Prevalence of protein-energy malnutrition risk in European older adults in the community, residential and hospital settings, according to 22 malnutrition screening tools validated for use in adults ≥65 years: A systematic review and meta-analysis.] Maturitas. 2019 Aug;126:80-89. </ref>  
Older adults are more likely to experience complications of COVID-19 than younger adults. Older adults with COVID-19 might need hospitalization, intensive care, or a ventilator to help them breathe and increase their chances of survival. The risk rises for people in their 50s and escalates in the 60s, 70s, and 80s. People 85 and older are the most likely to get very sick<ref>CDC Covid 19 risks and the elderly Available:https://www.cdc.gov/aging/covid19/covid19-older-adults.html (accessed 23.8.2022)</ref>. It affects people of all ages everywhere in the world, but most deaths from this disease occur in the elderly. The most susceptible individuals 65 years and older are those suffering two or more [[Multimorbidity|comorbidities]]. Furthermore, elderly with a history of [[Cardiovascular Disease|cardiovascular disease]], [[Diabetes|diabetes mellitus]], [[Chronic Obstructive Pulmonary Disease Rehabilitation Class|chronic obstructive pulmonary disease]], malignancy and [[Chronic Kidney Disease|chronic kidney disease]] are most at risk of dying from [[Coronavirus Disease (COVID-19)|COVID.]]<ref>Emami A, Javanmardi F, Pirbonyeh N, Akbari A. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096724/ Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis]. Arch Acad Emerg Med. 2020 Mar 24;8(1):e35.  </ref> Additional factors include disabilities, [[Cognitive Impairments|cognitive]] and mood disorders (eg [[depression]], [[Bipolar Disorder|bipolar]]), [[Polypharmacy|polypharmacotherapy]], social isolation, and [[COVID-19 and Nutrition|nutritional deficits]] often present in the residents of long-term care facilities.<ref name=":1">Leij-Halfwerk S, Verwijs MH, van Houdt S, Borkent JW, Guaitoli PR, Pelgrim T, Heymans MW, Power L, Visser M, Corish CA, de van der Schueren MAE; MaNuEL Consortium. [https://www.maturitas.org/article/S0378-5122(19)30114-8/fulltext Prevalence of protein-energy malnutrition risk in European older adults in the community, residential and hospital settings, according to 22 malnutrition screening tools validated for use in adults ≥65 years: A systematic review and meta-analysis.] Maturitas. 2019 Aug;126:80-89. </ref>  


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== Infection and Elderly                   ==
== Infection and the Elderly ==
The [[Immune System|immune system]] is responsible for overcoming infections due to the production of IgG anti-virus antibodies. The effectiveness of the immune system can be influenced by several factors but one of the problems leading to its poor responsiveness may be nutritional deficits present in the elderly. It can lead to severe inflammatory disease affecting the heart, lungs, kidneys and vascular system.<ref name=":0" />  
[[File:Inflammaging.jpeg|right|frameless]]
The [[Immune System|immune system]] is responsible for overcoming infections due to the production of IgG anti-virus [[Immunoglobulins (Ig)|antibodies]]. The immune system's effectiveness can be influenced by several factors, including nutritional deficits in the elderly. This can lead to severe inflammatory disease affecting the heart, lungs, kidneys and vascular system.<ref name=":0">Bencivenga L, Rengo G, Varricchi G. [https://link.springer.com/article/10.1007/s11357-020-00218-9 Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition]. GeroScience 2020, 42; 1089–1092. </ref>


Inflammaging ( chronic low-grade inflammation that develops with advanced age<ref name=":9">Ferrucci L, Fabbri E. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/pdf/nihms-987910.pdf Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty]. Nat Rev Cardiol. 2018 Sep;15(9):505-522. </ref>) is characterized by elevated levels of blood inflammatory markers<ref name=":9" /> frequently described in the elderly population and caused by 3 geriatric conditions: malnutrition, sarcopenia and frailty.<ref name=":3">Lengelé L, Locquet M, Moutschen M, Beaudart C, Kaux JF, Gillain S, Reginster JY, Bruyère O. [https://link.springer.com/article/10.1007/s40520-021-01991-z Frailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults.] Aging Clin Exp Res. 2021 Oct 23:1–12.</ref>
Cells' capacity to respond to infections is defined by the senescence process that begins when cells are dividing but not dying.<ref name=":10">Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M,  Alimonti A. [https://journals.physiology.org/doi/full/10.1152/physrev.00020.2018 Cellular Senescence: Aging, Cancer, and Injury]. Physiological Reviews 2019; 99(2): 1047-1078.</ref> Cells division is a natural cell ageing process, yet their resistance to death can lead to age-related pathologies. The accumulation of old (senescence) cells in various tissues can be responsible for cells' unnecessary damage.<ref>Ahmed AS, Sheng MH, Wasnik S, Baylink DJ, Lau KW. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316899/ Effect of ageing on stem cells.] World J Exp Med. 2017 Feb 20;7(1):1-10. </ref>Changes in the development and function of the immune system are called [[Immunosenescence|immunosenescence.]]<ref name=":10" /> This process can lead to an increased risk for disease development in the elderly.<ref name=":10" />  
== Nutritional Deficits in Elderly ==
[[File: NUTRITION FACTS.jpg|thumb]]According to the study completed in the European hospitals, residential care and community settings<ref name=":1" /> [[Nutrition|nutritional deficits]] in the elderly can be caused by reduced dietary intake in addition to age-related problems such as malabsorption, increased nutrient losses and augmented metabolic demands.<ref name=":0" /> Malnutrition caused by low intake of food high with vitamins, minerals and proteins directly affect the body's [[Immune System|immune responses]]:


* '''Low intake''' of food high with '''vitamins''', especially:
[[Inflammaging]] (chronic low-grade inflammation that develops with advanced age<ref name=":9">Ferrucci L, Fabbri E. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146930/pdf/nihms-987910.pdf Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty]. Nat Rev Cardiol. 2018 Sep;15(9):505-522. </ref>) presents with elevated levels of [[Blood Physiology|blood]] inflammatory markers<ref name=":9" /> frequently described in the elderly population and caused by three geriatric conditions: malnutrition, [[sarcopenia]] and [[Introduction to Frailty|frailty]].<ref name=":3">Lengelé L, Locquet M, Moutschen M, Beaudart C, Kaux JF, Gillain S, Reginster JY, Bruyère O. [https://link.springer.com/article/10.1007/s40520-021-01991-z Frailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults.] Aging Clin Exp Res. 2021 Oct 23:1–12.</ref>
** Vitamin A has an important role in the development and functioning of the immune system, increases the efficacy of T-cell-based viral vaccines<ref>Huang Z, Liu Y, Qi G, Brand D, Zheng S. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162863/ Role of vitamin A in the immune system]. J Clin Med. 2018;7:258</ref>
== Nutritional Deficits in the Elderly ==
** [[Vitamin B12 Deficiency|Vitamin B]] affects cell and immune system function and energy metabolism. Its deficiency leads to inflammation<ref name=":2">Shakoor H, Feehan J, Al Dhaheri AS, Ali HI, Platat C, Ismail LC, Apostolopoulos V, Stojanovska L. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415215/ Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19?] Maturitas. 2021 Jan;143:1-9. </ref>
[[File: NUTRITION FACTS.jpg|thumb]]According to a study completed in European hospitals, residential care and community settings<ref name=":1" /> [[Nutrition|nutritional deficits]] in the elderly can be caused by reduced dietary intake in addition to age-related problems such as malabsorption, increased nutrient losses and augmented metabolic demands.<ref name=":0" /> [[Malnutrition]] caused by low intake of food high with vitamins, minerals and [[proteins]] directly affect the body's [[Immune System|immune responses]]:  
** Vitamin C promotes antimicrobial activity and production of the antibody. Tends to be depleted during infections resulting in coagulopathy<ref>Carr AC. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137406/pdf/13054_2020_Article_2851.pdf A new clinical trial to test high-dose vitamin C in patients with COVID-19]. Crit Care. 2020;24:133.</ref>
** [[Vitamin D Deficiency|Vitamin D]] reduces the risk of infections, assist in immune responses<ref>Jakovac H. [https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00138.2020 COVID-19 and vitamin D-Is there a link and an opportunity for intervention?] Am J Physiol Endocrinol Metab. 2020;318:E589.</ref>
** Vitamin E stimulates the T-cell function.<ref>Lee GY, Han SN. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266234/ The role of vitamin E in immunity]. Nutrients. 2018;10.</ref>


* '''Low intake''' of food high with '''minerals,''' especially:
* '''Low intake''' of food high in '''vitamins''', especially:
** Zinc: enhances total number and function of T-cells<ref name=":2" />
** Vitamin A: has an important role in the development and functioning of the immune system and increases the efficacy of T-cell-based viral [[Vaccines|vaccine]]<nowiki/>s<ref>Huang Z, Liu Y, Qi G, Brand D, Zheng S. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162863/ Role of vitamin A in the immune system]. J Clin Med. 2018;7:258</ref>
** [[Iron]]: both excess and deficiency affects the functioning of the immune system<ref>Cherayil BJ. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173740/ Iron and immunity: immunological consequences of iron deficiency and overload.] Arch Immunol Ther Exp (Warsz). 2010 Dec;58(6):407-15. </ref>
** [[Vitamin B12 Deficiency|Vitamin B]]: affects cell and immune system function and energy metabolism. Deficiency of Vitamin B leads to [[Inflammation Acute and Chronic|inflammation]]<ref name=":2">Shakoor H, Feehan J, Al Dhaheri AS, Ali HI, Platat C, Ismail LC, Apostolopoulos V, Stojanovska L. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415215/ Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19?] Maturitas. 2021 Jan;143:1-9. </ref>
** [[Vitamin C Deficiency (Scurvy)|Vitamin C]]: promotes antimicrobial activity and the production of antibodies. Tends to be depleted during infections resulting in coagulopathy<ref>Carr AC. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137406/pdf/13054_2020_Article_2851.pdf A new clinical trial to test high-dose vitamin C in patients with COVID-19]. Crit Care. 2020;24:133.</ref>
** [[Vitamin D Deficiency|Vitamin D]]: reduces the risk of infections and assists in immune responses<ref>Jakovac H. [https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00138.2020 COVID-19 and vitamin D-Is there a link and an opportunity for intervention?] Am J Physiol Endocrinol Metab. 2020;318:E589.</ref>
** Vitamin E: stimulates T-cell function.<ref>Lee GY, Han SN. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266234/ The role of vitamin E in immunity]. Nutrients. 2018;10.</ref>
 
* '''Low intake''' of food high in '''minerals,''' especially:
** Zinc: enhances the total number and function of T-cells<ref name=":2" />
** [[Iron]]: both an excess and a deficiency of iron affect the functioning of the immune system<ref>Cherayil BJ. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173740/ Iron and immunity: immunological consequences of iron deficiency and overload.] Arch Immunol Ther Exp (Warsz). 2010 Dec;58(6):407-15. </ref>
** [https://www.saintlukeskc.org/about/news/new-research-suggests-magnesium-and-vitamin-d-can-help-reduce-covid-19-infections Magnesium]: co-factor for immunoglobulin synthesis, immune cell adherence, antibody-dependent cytolysis<ref>Tam M, Gómez S, González-Gross M, Marcos [https://www.nature.com/articles/1601689 A. Possible roles of magnesium on the immune system]. Eur J Clin Nutr. 2003 Oct;57(10):1193-7. </ref>
** [https://www.saintlukeskc.org/about/news/new-research-suggests-magnesium-and-vitamin-d-can-help-reduce-covid-19-infections Magnesium]: co-factor for immunoglobulin synthesis, immune cell adherence, antibody-dependent cytolysis<ref>Tam M, Gómez S, González-Gross M, Marcos [https://www.nature.com/articles/1601689 A. Possible roles of magnesium on the immune system]. Eur J Clin Nutr. 2003 Oct;57(10):1193-7. </ref>
** Copper: supports the immune system
** Copper: supports the immune system


* '''Low protein''' intake: leads to [https://www.medicalnewstoday.com/articles/315312 wasting syndrome]<ref name=":1" />
* '''Low protein''' intake: leads to [https://www.medicalnewstoday.com/articles/315312 wasting syndrome.]<ref name=":1" />See also [[Muscle Function and Protein]]


The risk of malnutrition can be assessed using the Mini Nutritional Assessment.<ref>Vellas B, Guigoz Y, Garry PJ, Nourhashemi F, Bennahum D, Lauque S, Albarede JL. [https://www.sciencedirect.com/science/article/abs/pii/S0899900798001713?via%3Dihub The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients]. Nutrition. 1999 Feb;15(2):116-22. </ref> This tool can identify if the individual is well-nourished, is at risk for malnutrition or is malnourished.




{{#ev: youtube|_yBx0GVO9vo|250}}<ref>Prof Janice Thompson. Busting myths about COVID-19 and nutrition. Available from: http://www.youtube.com/watch?v=_yBx0GVO9vo [last accessed 29/10/2021]</ref>


Muscle wasting syndrome in the elderly can be the result of the negative net protein balance as shown by research.<ref name=":12">Breen L, Phillips S.M. [https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-8-68?dom=translatable&src=syn Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing]. Nutr Metab (Lond) 2011; 8 (68). </ref> Inability of the aged person's muscles to synthesise protein in response to anabolic stimuli (diet, exercise) is a characteristic of anabolic resistance. Based on the scientific evidence<ref name=":12" />, it is recommended that the elderly person increase protein intake with each meal to effectively stimulate protein synthesis. <ref name=":12" />


The risk of [[malnutrition]] can be assessed using the Mini Nutritional Assessment.<ref>Vellas B, Guigoz Y, Garry PJ, Nourhashemi F, Bennahum D, Lauque S, Albarede JL. [https://www.sciencedirect.com/science/article/abs/pii/S0899900798001713?via%3Dihub The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients]. Nutrition. 1999 Feb;15(2):116-22. </ref> This tool can identify if the individual is well-nourished, is at risk for malnutrition or is malnourished.
{{#ev: youtube|_yBx0GVO9vo|250}}<ref>Prof Janice Thompson. Busting myths about COVID-19 and nutrition. Available from: http://www.youtube.com/watch?v=_yBx0GVO9vo [last accessed 29/10/2021]</ref>
=== Sarcopenia ===
=== Sarcopenia ===
[[Sarcopenia]] is a disease that originates at the cellular level. Faulty metabolism can be a causing factor, and symptoms include decreased [[muscle strength]] and muscle mass. The progressive cellular processes lead to poor outcomes in an individual's strength, mobility, and functional capacity.<ref>Tarantino U, Piccirilli E, Fantini M, Baldi J, Gasbarra E, Bei R. [https://www.mdpi.com/1660-4601/17/21/7732/htm State of Fragility Fractures Management during the COVID-19 Pandemic]. J Bone Joint Surg Am. 2015 Mar 4; 97(5):429-37.</ref><ref>Moreira VG, Perez M, Lourenço RA. [https://www.scielo.br/j/clin/a/KfrzfL5xvvpjpK4zRv9NzjS/?lang=en&format=pdf Prevalence of sarcopenia and its associated factors: the impact of muscle mass, gait speed, and handgrip strength reference values on reported frequencies.] Clinics (Sao Paulo). 2019 Apr 8;74:e477.</ref> It is considered one of the risk factors for COVID-19, and at the same time, hospitalisation with COVID-19 infection may lead to the disease.     
[[Sarcopenia]] is a disease that originates at the cellular level. Faulty metabolism can be a causative factor, and symptoms include decreased [[Muscle Strength Testing|muscle strength]] and muscle mass. The progressive cellular processes lead to poor outcomes in an individual's strength, mobility, and functional capacity.<ref>Tarantino U, Piccirilli E, Fantini M, Baldi J, Gasbarra E, Bei R. [https://www.mdpi.com/1660-4601/17/21/7732/htm State of Fragility Fractures Management during the COVID-19 Pandemic]. J Bone Joint Surg Am. 2015 Mar 4; 97(5):429-37.</ref><ref>Moreira VG, Perez M, Lourenço RA. [https://www.scielo.br/j/clin/a/KfrzfL5xvvpjpK4zRv9NzjS/?lang=en&format=pdf Prevalence of sarcopenia and its associated factors: the impact of muscle mass, gait speed, and handgrip strength reference values on reported frequencies.] Clinics (Sao Paulo). 2019 Apr 8;74:e477.</ref> It is considered one of the risk factors for COVID-19; at the same time, hospitalisation with COVID-19 infection may lead to sarcopenia.     
[[File:Sarcopenia.jpg|thumb|Factors that cause and worsen muscle quantity and quality]]     
[[File:Sarcopenia.jpg|thumb|Factors that cause and worsen muscle quantity and quality]]     


Clinically patients with sarcopenia demonstrate compromised function of the [[Respiratory Disorders|respiratory system]], immunological system, and metabolic system among others.<ref>Wang PY, Li Y, Wang Q. Sarcopenia: [https://reader.elsevier.com/reader/sd/pii/S0899900720303877?token=452DDF9F169122CF8161B7F242BF5FE0BE63F3115A97A94087D020AB4702D62A5D78B06C50447E8937E8C5F73EB64AFA&originRegion=eu-west-1&originCreation=20211028222445 An underlying treatment target during the COVID-19 pandemic]. Nutrition. 2021 Apr;84:111104. </ref> Definition for this clinical presentation was revised in 2018 by the European Working Group on Sarcopenia in Older People (EWGSOP2) and is now used internationally for diagnostic purposes.<ref>Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. [https://watermark.silverchair.com/afy169.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsYwggLCBgkqhkiG9w0BBwagggKzMIICrwIBADCCAqgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMEGwT0BgPG9nULjqMAgEQgIICefSF0BNzeqbOrQPXvnlGR9TYl-LM7tXViqg_PIk8yXYdvPzKp67uOWteoi6sZFFu8F0Nq34ewrofgrkiYSZURok_LrgiO3J-aXGCDyz7bZwcHn79E2Nt3QKNeM3OnW7l034gRdTCRVekqviL7_fQ5cgbK8zyUQJennl4tG25qRL6I-aGKpLaoovs6IxDsgbtGGnJPXHrk3swEZE-RFt8m35vsXu8Mo51dQIMBhyJQzUvpqZgbdjUtnj2eKibw-GlSE-eGYWAtypK0UFciTNAN-0tUXQ14DC5Pl-mtyFHU4ezgeiz9pTcp9zFJ-wGTacr-bAHdGN9z1M7unkOYJCkWH9EXCyeB6EyXQTFO6o-ljr6j_1Ogx0POuJQOlbDdA3fo-vUvfEQWDt9zAikmOyYo9WqZGZRfNajk6B6e7_-0qCRw8YxfGUZv8U4EWwVik4uL_aBxJubgeLNz5OgGl2swZGStEOINYQehKD_S8FHU2jyToo_ztqT15z0oARf5Z3QjPY4u1q0ntaOmQ_ysxl5GiqLbvSxiE-f-PslUXjo3RnhahXU6Tts2L20qmKDT7_XrcmeDKtIeR3Up8NNY4aFR-cZtY9nm-miRvzogHoCrfv0fGsnn13GG1Xm4ETXPP5mwTApDO2SAL72-PFPObKKICqt4bKj9ocEA_BOFsL2vSFpHuAAtDHCdGtJUzxD4VlE92tIZMIUBg3l4_nR9GA9nCNh0KCHJixnyOfW3TxoQXq3NNF1YS4SiRRrbpZVbZAfbrxvzFV7vBYtMM8xnAVw4GlUu7oRnQKjiUOnGUbTwZRFoHFA7VtXymoAhuji5Imh21BnY-XwijogeA Sarcopenia: revised European consensus on definition and diagnosis]. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169. Erratum in: Age Ageing. 2019 Jul 1;48(4):601.</ref>  
Clinically, patients with sarcopenia demonstrate compromised function of the [[Respiratory Disorders|respiratory system]], immunological, and metabolic systems, among others.<ref>Wang PY, Li Y, Wang Q. Sarcopenia: [https://reader.elsevier.com/reader/sd/pii/S0899900720303877?token=452DDF9F169122CF8161B7F242BF5FE0BE63F3115A97A94087D020AB4702D62A5D78B06C50447E8937E8C5F73EB64AFA&originRegion=eu-west-1&originCreation=20211028222445 An underlying treatment target during the COVID-19 pandemic]. Nutrition. 2021 Apr;84:111104. </ref> Definition for this clinical presentation was revised in 2018 by the European Working Group on Sarcopenia in Older People (EWGSOP2) and is now used internationally for diagnostic purposes.<ref>Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. [https://watermark.silverchair.com/afy169.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsYwggLCBgkqhkiG9w0BBwagggKzMIICrwIBADCCAqgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMEGwT0BgPG9nULjqMAgEQgIICefSF0BNzeqbOrQPXvnlGR9TYl-LM7tXViqg_PIk8yXYdvPzKp67uOWteoi6sZFFu8F0Nq34ewrofgrkiYSZURok_LrgiO3J-aXGCDyz7bZwcHn79E2Nt3QKNeM3OnW7l034gRdTCRVekqviL7_fQ5cgbK8zyUQJennl4tG25qRL6I-aGKpLaoovs6IxDsgbtGGnJPXHrk3swEZE-RFt8m35vsXu8Mo51dQIMBhyJQzUvpqZgbdjUtnj2eKibw-GlSE-eGYWAtypK0UFciTNAN-0tUXQ14DC5Pl-mtyFHU4ezgeiz9pTcp9zFJ-wGTacr-bAHdGN9z1M7unkOYJCkWH9EXCyeB6EyXQTFO6o-ljr6j_1Ogx0POuJQOlbDdA3fo-vUvfEQWDt9zAikmOyYo9WqZGZRfNajk6B6e7_-0qCRw8YxfGUZv8U4EWwVik4uL_aBxJubgeLNz5OgGl2swZGStEOINYQehKD_S8FHU2jyToo_ztqT15z0oARf5Z3QjPY4u1q0ntaOmQ_ysxl5GiqLbvSxiE-f-PslUXjo3RnhahXU6Tts2L20qmKDT7_XrcmeDKtIeR3Up8NNY4aFR-cZtY9nm-miRvzogHoCrfv0fGsnn13GG1Xm4ETXPP5mwTApDO2SAL72-PFPObKKICqt4bKj9ocEA_BOFsL2vSFpHuAAtDHCdGtJUzxD4VlE92tIZMIUBg3l4_nR9GA9nCNh0KCHJixnyOfW3TxoQXq3NNF1YS4SiRRrbpZVbZAfbrxvzFV7vBYtMM8xnAVw4GlUu7oRnQKjiUOnGUbTwZRFoHFA7VtXymoAhuji5Imh21BnY-XwijogeA Sarcopenia: revised European consensus on definition and diagnosis]. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169. Erratum in: Age Ageing. 2019 Jul 1;48(4):601.</ref>Clinical assessment should follow recommendations published by the International Working Group on Sarcopenia that include:<ref name=":11">Cooper C, Fielding R, Visser M, van Loon LJ, Rolland Y, Orwoll E, Reid K, Boonen S, Dere W, Epstein S, Mitlak B, Tsouderos Y, Sayer AA, Rizzoli R, Reginster JY, Kanis JA. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744387/pdf/emss-54295.pdf Tools in the assessment of sarcopenia]. Calcif Tissue Int. 2013 Sep;93(3):201-10. </ref>
 
* assessment of physical capabilities
* ruling out sarcopenia in non-ambulatory patients
* 4 meters usual walking pace test
* [[Body Composition|body composition]] measurement.
 
The following are the most commonly used physiotherapy assessment tools:<ref name=":11" />
 
* gait speed (timed 4-metre [[10 Metre Walk Test|walk test]])
* [[30 Seconds Sit To Stand Test|sit-stand time]]
* [[The 4-Stage Balance Test|standing balance]]
* muscle power measurement
* self-reported measures of [[Activities of Daily Living|ADLs]].
 
=== Frailty ===
=== Frailty ===
[[Introduction to Frailty|Frailty]] is a COVID risk factor and the person with the syndrome of frailty must present with three or more symptoms:<ref name=":4">Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al.[https://watermark.silverchair.com/M146.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAt4wggLaBgkqhkiG9w0BBwagggLLMIICxwIBADCCAsAGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM2D1C2_D6ZKliKlQXAgEQgIICkZRaR6Yqk_WYGJ3CuLvnywljds4TeMgw5naSzS8xRD-R6y1WEWuqp-9npct_CtkeKI0BdJV4eYv1y18DGTztKqSSlxFWU6tD5kGzsS6TedlrBX0A_befWTEWfs-KzsMFd0kYyqtx6cQodtsAmZz_VNTUtgZLr5ISP23l2WFP3wsGqAw4tXfo_GK05s0caqUfbZ5AaUqivdxrY6crYg26I07b_cXGlUNnH35jSm5ns9uLCJhFe9XzuS3uV9vkvYvYidmnFpc0jv7ox4qT_8azIEVjJSknSZLmeWqEDDbxeGqRvnLCHWoq-eIw90eW78GQwpjX_1odEEmntSTgDxuwwaPXl-kx3GQmmgk_NYxo0_tRycr2RQcDuSK5i-usczS0YJ4-uj_8GDynresjkiJFCVnXX6RnPktre3g2RlxNOqrNwGIQ-blE7KxSK7H_1_nq4DrpZySQK3PO6YHFaDvwRRl1THMTk6k1pjro6dnQ0ttE3LlD4VCyfBm5Luwstp73r7OBvvDJmcEy1SJwynDYFLLEpFvuDFbwgxzvET9Lrjsr6xsJatirV_55JOK8NrvJ0KBrDIOD4HlHOkxhxROP5pufbVMSNwQtz47icdhqhYzntCCbcz_BHiWvUXL8k8r1IVzlxq_wU53npVRRx3V9CVIOQ9hjQ4Zt74k0wxHb9-wburQYIBltB1gbddbRPfUR06MZkdj5f9KMVg2u_WG3VEJPnFfybXNI-d1g0h6LmOpSSk776s0VQJvabErRVHUd9Y8YuPzGR_BbakyMrJELuT0XS-msAMM1PEPi8M8EWh0gB5jn-GRbHilDkOwQDM-gDzpiQeFQ899EUUOJLpaDuT9Yj1GPs-pr-AKYjmgCaBNyKA Frailty in Older Adults: Evidence for a Phenotype]. The Journals of Gerontology 2001: Series A 56(3): M146–M157.</ref>                                                                                       
[[File:Screenshot 2021-11-08 at 11.03.54.jpg|thumb]]
[[Introduction to Frailty|Frailty]] is a risk factor for COVID. An individual with frailty must present with three or more symptoms, including:<ref name=":4">Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al.[https://watermark.silverchair.com/M146.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAt4wggLaBgkqhkiG9w0BBwagggLLMIICxwIBADCCAsAGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM2D1C2_D6ZKliKlQXAgEQgIICkZRaR6Yqk_WYGJ3CuLvnywljds4TeMgw5naSzS8xRD-R6y1WEWuqp-9npct_CtkeKI0BdJV4eYv1y18DGTztKqSSlxFWU6tD5kGzsS6TedlrBX0A_befWTEWfs-KzsMFd0kYyqtx6cQodtsAmZz_VNTUtgZLr5ISP23l2WFP3wsGqAw4tXfo_GK05s0caqUfbZ5AaUqivdxrY6crYg26I07b_cXGlUNnH35jSm5ns9uLCJhFe9XzuS3uV9vkvYvYidmnFpc0jv7ox4qT_8azIEVjJSknSZLmeWqEDDbxeGqRvnLCHWoq-eIw90eW78GQwpjX_1odEEmntSTgDxuwwaPXl-kx3GQmmgk_NYxo0_tRycr2RQcDuSK5i-usczS0YJ4-uj_8GDynresjkiJFCVnXX6RnPktre3g2RlxNOqrNwGIQ-blE7KxSK7H_1_nq4DrpZySQK3PO6YHFaDvwRRl1THMTk6k1pjro6dnQ0ttE3LlD4VCyfBm5Luwstp73r7OBvvDJmcEy1SJwynDYFLLEpFvuDFbwgxzvET9Lrjsr6xsJatirV_55JOK8NrvJ0KBrDIOD4HlHOkxhxROP5pufbVMSNwQtz47icdhqhYzntCCbcz_BHiWvUXL8k8r1IVzlxq_wU53npVRRx3V9CVIOQ9hjQ4Zt74k0wxHb9-wburQYIBltB1gbddbRPfUR06MZkdj5f9KMVg2u_WG3VEJPnFfybXNI-d1g0h6LmOpSSk776s0VQJvabErRVHUd9Y8YuPzGR_BbakyMrJELuT0XS-msAMM1PEPi8M8EWh0gB5jn-GRbHilDkOwQDM-gDzpiQeFQ899EUUOJLpaDuT9Yj1GPs-pr-AKYjmgCaBNyKA Frailty in Older Adults: Evidence for a Phenotype]. The Journals of Gerontology 2001: Series A 56(3): M146–M157.</ref>                                                                                       


* unintentional weight loss (10 lbs in the past year)
* Unintentional weight loss (10 lbs/ 4.5kg in the past year)
* self-reported exhaustion  
* Self-reported exhaustion
* weakness (grip strength)  
* Weakness ([[Grip Strength|grip strength]])
* slow walking speed  
* Slow walking speed
* low [[Physical Activity as an Anti-Aging Medicine|physical activity]].
* Low [[Physical Activity as an Anti-Aging Medicine|physical activity]]


A person with two or fewer deficits listed above is considered in the pre-frail stage and one displaying no deficits is identified as robust.<ref name=":3" />
A person with two or fewer deficits listed above is considered in the pre-frail stage. An individual with no deficits is identified as robust.<ref name=":3" />


Due to reduction in 'physiological reserve affecting immune function and adaptation to acute stressors'<ref name=":3" /> frailty is considered high risk for mortality, institutionalization, [[falls]], and hospitalisation.<ref name=":4" />  
Due to a reduction in 'physiological reserve affecting immune function and adaptation to acute stressors',<ref name=":3" /> frailty is considered high risk for mortality, institutionalisation, [[falls]], and hospitalisation.<ref name=":4" />  


{{#ev:youtube|UT_T2I3p5GI|250}}<ref>Dr Ken Rockwood speaks about frailty and COVID-19. Available from: http://www.youtube.com/watch?v=UT_T2I3p5GI [last accessed 29/10/2021]</ref>
{{#ev:youtube|UT_T2I3p5GI|250}}<ref>Dr Ken Rockwood speaks about frailty and COVID-19. Available from: http://www.youtube.com/watch?v=UT_T2I3p5GI [last accessed 29/10/2021]</ref>
== Typical Presentation of COVID ==
== Typical Presentation of COVID ==
The [https://www.ecdc.europa.eu/en European Centre for Disease Prevention and Control (ECDC)] conducted the study on clinical characteristics of COVID-19.<ref>European Centre for Disease Prevention and Control. Available from https://www.ecdc.europa.eu/en/covid-19/latest-evidence/clinical (accessed 28 Oct 2021).</ref> The most common symptoms included:
The [https://www.ecdc.europa.eu/en European Centre for Disease Prevention and Control (ECDC)] conducted the study on clinical characteristics of COVID-19. However, the study indicated that 40% of COVID-19 cases are asymptomatic.<ref>European Centre for Disease Prevention and Control. Available from https://www.ecdc.europa.eu/en/covid-19/latest-evidence/clinical (accessed 19 Oct 2022).</ref> The most common symptoms included:


* [[headache]]
* Cough
* loss of smell
* [[Fever]]
* nasal obstruction
* Fatigue
* cough
* Myalgia (muscle aches and pain)
* asthenia (lack of energy, physical weakness)
* [[Headache]]
* myalgia (muscle aches and pain)
* Loss of smell
* rhinorrhoea ( nasal discharge)
* Nasal obstruction
* gustatory dysfunction (taste disturbance)
* Asthenia (lack of energy, physical weakness)
* soar throat
* Rhinorrhoea ( nasal discharge)
* fever
* Olfactory and gustatory dysfunction (taste disturbance)
* Soar throat


== Atypical Presentation of COVID in the Elderly ==
== Atypical Presentation of COVID in the Elderly ==
With age‐related changes in immunity, COVID may have an atypical presentation in the elderly population. <ref>Soysal P, Kara O. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405320/pdf/PSYG-9999-na.pdf Delirium as the first clinical presentation of the coronavirus disease 2019 in an older adult]. Psychogeriatrics. 2020 Sep;20(5):763-765. </ref><ref>Rawle M, Bertfield D, Brill S. (2020). Atypical presentations of COVID‐19 in care home residents presenting to secondary care: A UK single centre study. AGING MEDICINE 2020. https://onlinelibrary.wiley.com/doi/10.1002/agm2.12126. (Accessed 29 Oct 2021)</ref>  
With age‐related changes in immunity, COVID may present atypically in the elderly population. <ref>Soysal P, Kara O. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405320/pdf/PSYG-9999-na.pdf Delirium as the first clinical presentation of the coronavirus disease 2019 in an older adult]. Psychogeriatrics. 2020 Sep;20(5):763-765. </ref><ref>Rawle M, Bertfield D, Brill S. (2020). Atypical presentations of COVID‐19 in care home residents presenting to secondary care: A UK single centre study. AGING MEDICINE 2020. https://onlinelibrary.wiley.com/doi/10.1002/agm2.12126. (Accessed 29 Oct 2021)</ref>  


=== 1. Hypoactive Delirium ===
=== 1. Hypoactive Delirium ===
There are 3 motor subtypes of delirium: hypoactive, hyperactive and mixed category.<ref>Lipowski ZJ. Transient cognitive disorder in the elderly. Am J Psychiatry 1982;140:1426–36.</ref> Hypoactive delirium is the most common subtype of delirium in the geriatric population.<ref name=":5">Soysal P, Ahmet TI.[https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.12720 Hypoactive delirium caused by pulmonary embolus in an elderly adult]. J Am Geriatr Soc. 2014 Mar;62(3):586-7.</ref> The symptoms include lethargy, confusion, and apathy.<ref>Meagher DJ, Leonard M, Donnelly S, Conroy M, Adamis D, Trzepacz PT. [https://www.sciencedirect.com/science/article/abs/pii/S0022399911001693 A longitudinal study of motor subtypes in delirium: relationship with other phenomenology, aetiology, medication exposure and prognosis]. J Psychosom Res. 2011 Dec;71(6):395-403. </ref>  Because of the patients' behaviour with no signs of agitation, irritation, anger or aggression, they are often wrongly diagnosed with [[depression]] or [[dementia]].<ref name=":5" /> Hypoactive delirium is associated with systemic infection aetiologies and has a lower overall burden of delirium symptoms than the other motor subtypes,<ref name=":6">Glynn K, McKenna F, Lally K, et al. [https://bmjopen.bmj.com/content/bmjopen/11/4/e041214.full.pdf How do delirium motor subtypes differ in phenomenology and contributory aetiology? a cross-sectional, multisite study of liaison psychiatry and palliative care patients.] BMJ Open 2021;11:e041214. </ref> but has been linked to increased risk of mortality.<ref>Yang FM, Marcantonio ER, Inouye SK, et al. [https://www.sciencedirect.com/science/article/pii/S0033318209707959 Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis]. Psychosomatics 2009;50:248–54.</ref><ref>Jackson TA, Wilson D, Richardson S, et al. Predicting outcome in older hospital patients with delirium: a systematic literature review. Int J Geriatr Psychiatry 2016;31:392–9.</ref>
There are three motor subtypes of [[ICU Delirium|Delirium]]:<ref>Lipowski ZJ. Transient cognitive disorder in the elderly. Am J Psychiatry 1982;140:1426–36.</ref>
==== Assessment tools  ====
{| class="wikitable"
Diagnostic tools to determine a patient's status include standardised testing and information received from the medical record as well as reports from the patient's care team: nursing staff and the family. <ref name=":6" />  
!Subtype
!Clinical Manifestations
|-
|Hyperactive
|Agitation, restlessness, emotional lability, hallucinations
|-
|Hypoactive
|Lethargy, decreased responsiveness, slowed motor skills
|-
|Mixed
|Fluctuation between hyper- and hypoactive symptoms
|}
Hypoactive delirium is the most common subtype of delirium in the geriatric population.<ref name=":5">Soysal P, Ahmet TI.[https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.12720 Hypoactive delirium caused by pulmonary embolus in an elderly adult]. J Am Geriatr Soc. 2014 Mar;62(3):586-7.</ref> The symptoms include lethargy, confusion, and apathy.<ref>Meagher DJ, Leonard M, Donnelly S, Conroy M, Adamis D, Trzepacz PT. [https://www.sciencedirect.com/science/article/abs/pii/S0022399911001693 A longitudinal study of motor subtypes in delirium: relationship with other phenomenology, aetiology, medication exposure and prognosis]. J Psychosom Res. 2011 Dec;71(6):395-403. </ref>  Because the patient displays no signs of agitation, irritation, anger or aggression, they are often wrongly diagnosed with [[depression]] or [[dementia]].<ref name=":5" /> Hypoactive delirium is associated with systemic infection aetiologies and has a lower overall burden of delirium symptoms than the other motor subtypes.<ref name=":6">Glynn K, McKenna F, Lally K, et al. [https://bmjopen.bmj.com/content/bmjopen/11/4/e041214.full.pdf How do delirium motor subtypes differ in phenomenology and contributory aetiology? a cross-sectional, multisite study of liaison psychiatry and palliative care patients.] BMJ Open 2021;11:e041214. </ref> However, it has been linked to increased mortality risk.<ref>Yang FM, Marcantonio ER, Inouye SK, et al. [https://www.sciencedirect.com/science/article/pii/S0033318209707959 Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis]. Psychosomatics 2009;50:248–54.</ref><ref>Jackson TA, Wilson D, Richardson S, et al. Predicting outcome in older hospital patients with delirium: a systematic literature review. Int J Geriatr Psychiatry 2016;31:392–9.</ref>
==== Assessment Tools ====
Diagnostic tools to determine a patient's status include standardised testing, information received from the medical record, and reports from the patient's care team: nursing staff and the family. <ref name=":6" />  


Standardised tests:                                                                 
Standardised tests:                                                                 
Line 91: Line 123:
* [https://static.cambridge.org/content/id/urn:cambridge.org:id:article:S1041610218000777/resource/name/S1041610218000777sup001.pdf Delirium Aetiology Checklist (DEC)]
* [https://static.cambridge.org/content/id/urn:cambridge.org:id:article:S1041610218000777/resource/name/S1041610218000777sup001.pdf Delirium Aetiology Checklist (DEC)]
* [https://deliriumnetwork.org/wp-content/uploads/2018/05/DRS-R-98.pdf Delirium Rating Scale Revised-98 (DRS R98)]
* [https://deliriumnetwork.org/wp-content/uploads/2018/05/DRS-R-98.pdf Delirium Rating Scale Revised-98 (DRS R98)]
* [https://static1.squarespace.com/static/543cac47e4b0388ca43554df/t/5f0592e7917a0733e509ea0b/1594200808505/4AT+v1_2+Oct+2014.pdf 4AT]
* [https://patient.info/doctor/abbreviated-mental-test-amt AMT]
==== Clinical Management ====
==== Clinical Management ====
Management of Hypoactive Delirium includes pharmacological and non-pharmacological approaches.<ref>van Velthuijsen EL, Zwakhalen SMG, Mulder WJ, Verhey FRJ, Kempen GIJM. Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice. Int J Geriatr Psychiatry. 2018 Nov;33(11):1521-1529. </ref>  
Management of hypoactive delirium includes pharmacological and non-pharmacological approaches.<ref>van Velthuijsen EL, Zwakhalen SMG, Mulder WJ, Verhey FRJ, Kempen GIJM. Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice. Int J Geriatr Psychiatry. 2018 Nov;33(11):1521-1529. </ref>  


Non-pharmacological treatment:
Non-pharmacological treatment:
Line 100: Line 134:
** Orientation box (clock, diary, information leaflet, radio, TV, music)
** Orientation box (clock, diary, information leaflet, radio, TV, music)
** [[Sleep: Regulation and Assessment|Circadian rhythm]] (healthy sleep-wake cycle)
** [[Sleep: Regulation and Assessment|Circadian rhythm]] (healthy sleep-wake cycle)
** Family participation (family staying at night, room filled with family photos, personal items, pillow, blanket)
** MDT ([[Multidisciplinary Team]]) and family participation (family staying at night, room filled with family photos, personal items, pillow, blanket)
* Psychosocial
* Psychosocial
** Delirium consultation (consultation by a specialist: nurse practitioner, geriatrician, psychiatrist)
** Delirium consultation (consultation by a specialist: nurse practitioner, geriatrician, psychiatrist)
** Delirium observation screening score (delirium severity measurement: 13 observations)
** Delirium observation screening score (delirium severity measurement: 13 observations)
* Other
** Respiratory Treatment ([[Active Cycle of Breathing Technique|ACBT]])
** Repositioning
** Passive [[Range of Motion]]


=== 2. Falls ===
=== 2. Falls ===
Syncope, near syncope, or non-mechanical [[falls]] are atypical features of COVID.<ref>Chen T, Hanna J, Walsh EE, Falsey AR, Laguio-Vila M, Lesho E. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205625/pdf/main.pdf Syncope, Near Syncope, or Nonmechanical Falls as a Presenting Feature of COVID-19]. Ann Emerg Med. 2020 Jul;76(1):115-117. </ref>  The aetiology of syncope or near syncope fall can be cardiogenic and non-cardiogenic including:
Syncope, near syncope, or non-mechanical [[falls]] are atypical features of COVID.<ref>Chen T, Hanna J, Walsh EE, Falsey AR, Laguio-Vila M, Lesho E. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205625/pdf/main.pdf Syncope, Near Syncope, or Nonmechanical Falls as a Presenting Feature of COVID-19]. Ann Emerg Med. 2020 Jul;76(1):115-117. </ref>  The aetiology of syncope or near syncope fall can be cardiogenic and non-cardiogenic, including:


* history of [[Cardiovascular Disease|cardiovascular disease]]
* History of [[Cardiovascular Disease|cardiovascular disease]]
* supplemental [[Oxygen Therapy|oxygen]] requirement  
* Supplemental [[Oxygen Therapy|oxygen]] requirement
* gastrointestinal symptoms
* Gastrointestinal symptoms
* elevated troponin level
* Elevated troponin level


The consequences of falls are one of the main causes of disability among the elderly population leading to a reduction in the [[Quality of Life|quality of life]], loss of independence and limited social functioning.<ref>Gawronska K, Lorkowski J. [https://journals.sagepub.com/doi/pdf/10.1177/2151459321996619 Falls as One of the Atypical Presentations of COVID-19 in Older Population]. Geriatric Orthopaedic Surgery & Rehabilitation. January 2021. </ref>
The consequences of falls are one of the main causes of disability among the elderly population leading to a reduction in [[Quality of Life|quality of life]], loss of independence and limited social functioning.<ref>Gawronska K, Lorkowski J. [https://journals.sagepub.com/doi/pdf/10.1177/2151459321996619 Falls as One of the Atypical Presentations of COVID-19 in Older Population]. Geriatric Orthopaedic Surgery & Rehabilitation. January 2021. </ref>
==== Assessment Tools ====
==== Assessment Tools ====
Holistic, multidisciplinary assessment should be considered when evaluating elderly patients with COVID who are at risk for falls and should include:
Holistic, multidisciplinary assessment should be considered when evaluating elderly patients with COVID who are at risk of falls and should include:


* [[Falls Risk Assessment Tool (FRAT): An Overview to Assist Understanding and Conduction|fall risk assessment]]
* [[Falls Risk Assessment Tool (FRAT): An Overview to Assist Understanding and Conduction|Fall risk assessment]]
* evaluation of [[Motor Assessment Scale|motor functions]]
* Evaluation of [[Motor Assessment Scale|motor functions]]
* assessment of [[Cognitive Deficits|cognitive]] impairment
* Assessment of [[Cognitive Impairments|cognitive]] impairment
* [[Mental Health Outcome Measures for Physiotherapists in Clinical Practice|mental]] performance assessment.
* [[Mental Health Outcome Measures for Physiotherapists in Clinical Practice|Mental]] performance assessment
==== Clinical Management  ====
==== Clinical Management  ====
Key principles for clinical management of patients with fall risk are:
Key principles for clinical management of patients with fall risk are:


* education and support for caregivers
* Education and support for caregivers
* close surveillance to ensure patients' adherence to pharmacological treatment<ref>Bianchetti A, Bellelli G, Guerini F. et al. [https://link.springer.com/article/10.1007/s40520-020-01641-w#citeas Improving the care of older patients during the COVID-19 pandemic]. Aging Clin Exp Res 2020; 32:1883–1888. </ref>
* Close surveillance to ensure patients' adherence to pharmacological treatment<ref>Bianchetti A, Bellelli G, Guerini F. et al. [https://link.springer.com/article/10.1007/s40520-020-01641-w#citeas Improving the care of older patients during the COVID-19 pandemic]. Aging Clin Exp Res 2020; 32:1883–1888. </ref>
* providing access to [[Nutrition|nutritious]] food, social and [[Mental Health Issues and Rehabilitation. |mental health]] support and information to maintain patients emotional well-being<ref>Cudjoe TKM, Kotwal AA. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267573/ "Social Distancing" Amid a Crisis in Social Isolation and Loneliness]. J Am Geriatr Soc. 2020 Jun;68(6):E27-E29. </ref>
* Providing access to [[Nutrition|nutritious]] food, social and [[Mental Health Issues and Rehabilitation |mental health]] support and information to maintain patients' emotional well-being<ref>Cudjoe TKM, Kotwal AA. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267573/ "Social Distancing" Amid a Crisis in Social Isolation and Loneliness]. J Am Geriatr Soc. 2020 Jun;68(6):E27-E29. </ref>
* early planning of post-[[Discharge Planning|discharge]] care.
* Early planning of post-[[Discharge Planning|discharge]] care
=== 3. Anorexia of ageing ===
=== 3. Anorexia of Ageing ===
Anorexia of ageing is a loss of appetite due to the ageing process<ref name=":7">Cox NJ, Morrison L, Ibrahim K, Robinson SM, Sayer AA, Roberts HC. [https://academic.oup.com/ageing/article/49/4/526/5733078 New horizons in appetite and the anorexia of ageing]. Age and Ageing 2020; 49(4): 526–534</ref>, and it can lead to :
Anorexia is a loss of appetite due to the ageing process<ref name=":7">Cox NJ, Morrison L, Ibrahim K, Robinson SM, Sayer AA, Roberts HC. [https://academic.oup.com/ageing/article/49/4/526/5733078 New horizons in appetite and the anorexia of ageing]. Age and Ageing 2020; 49(4): 526–534</ref>, and it can lead to:


* decrease oral intake  
* Decrease oral intake
* weight loss
* Weight loss
* increased risk of malnutrition,
* Increased risk of malnutrition
* sarcopenia  
* Sarcopenia  
* frailty.<ref name=":7" />  
* Frailty<ref name=":7" />  


It is a condition present among the elderly living in all environments. It affects patients admitted to acute care hospitals the most (42%). 30% of individuals living in the care home and 22% of community-dwelling elderly individuals have been diagnosed with anorexia of ageing.<ref>van der Meij BS, Wijnhoven HAH, Lee JS et al.  [https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.15017 Poor appetite and dietary intake in community-dwelling older adults]. J Am Geriatr Soc 2017; 65: 2190–7.</ref> Pathogenesis of the anorexia of ageing has a direct relationship with changes occurring in three "regulators" of appetite: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341214/pdf/BPH-172-5225.pdf physiological signalling], [https://theconversation.com/what-is-hedonism-and-how-does-it-affect-your-health-78040 hedonism] and external cues. <ref name=":7" />
It is a condition present among the elderly living in all environments. It affects patients admitted to acute care hospitals the most (42%). 30% of individuals living in care homes and 22% of community-dwelling elderly individuals have been diagnosed with anorexia.<ref>van der Meij BS, Wijnhoven HAH, Lee JS et al.  [https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.15017 Poor appetite and dietary intake in community-dwelling older adults]. J Am Geriatr Soc 2017; 65: 2190–7.</ref> Pathogenesis of the anorexia of ageing has a direct relationship with changes occurring in three "regulators" of appetite: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341214/pdf/BPH-172-5225.pdf physiological signalling], [https://theconversation.com/what-is-hedonism-and-how-does-it-affect-your-health-78040 hedonism] and external cues.<ref name=":7" />


Anorexia was diagnosed in 8.4% of the elderly population with COVID-19, and the mortality rate due to [[malnutrition]] was high.<ref>Neumann-Podczaska A, Al-Saad SR, Karbowski LM, Chojnicki M, Tobis S, Wieczorowska-Tobis K. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390523/ COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review]. Aging Dis. 2020 Jul 23;11(4):988-1008. </ref>  
Anorexia was diagnosed in 8.4% of the elderly with COVID-19, and the mortality rate was high due to [[malnutrition]].<ref>Neumann-Podczaska A, Al-Saad SR, Karbowski LM, Chojnicki M, Tobis S, Wieczorowska-Tobis K. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390523/ COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review]. Aging Dis. 2020 Jul 23;11(4):988-1008. </ref>  


==== Assessment Tools ====
==== Assessment Tools ====
The standardised tools for assessing appetite are not yet available.<ref name=":7" />
Standardised tools for assessing appetite are not yet available.<ref name=":7" />


The following are the most commonly used instruments for appetite assessment:<ref>Molfino A, Kaysen GA, Chertow GM, Doyle J, Delgado C, Dwyer T, Laviano A, Rossi Fanelli F, Johansen KL. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796001/ Validating Appetite Assessment Tools Among Patients Receiving Hemodialysis]. J Ren Nutr. 2016 Mar;26(2):103-10</ref>
The most commonly used appetite assessment instruments are <ref>Molfino A, Kaysen GA, Chertow GM, Doyle J, Delgado C, Dwyer T, Laviano A, Rossi Fanelli F, Johansen KL. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796001/ Validating Appetite Assessment Tools Among Patients Receiving Hemodialysis]. J Ren Nutr. 2016 Mar;26(2):103-10</ref>


* Self-assessment
* Self-assessment
Line 155: Line 193:


==== Clinical Management ====
==== Clinical Management ====
When managing an individual with poor appetite medical causes needs to be ruled out first. Medical conditions   known to affect appetite are:
When managing an individual with a poor appetite, medical causes need to be ruled out first. Medical conditions known to affect appetite are:


* Chronic heart disease
* Chronic heart disease
Line 164: Line 202:
* Swallowing deficits ([[dysphagia]]).<ref name=":7" />
* Swallowing deficits ([[dysphagia]]).<ref name=":7" />


With no medical causes identified, there is a lack of an evidence-based treatment approach to manage anorexia of ageing. It is suggested that the treatment plan should include:
If no medical causes are identified, there is a lack of evidence-based treatments to manage anorexia. It is suggested that the treatment plan should include the following:
* nutritional recommendations
* Nutritional recommendations
* oral nutritional supplements (ONS)  
* Oral nutritional supplements (ONS)
*[[Psychological Factors in Ageing|psychological]] support
*[[Psychological Factors in Ageing|Psychological]] support
* family-based therapy.
* Family-based therapy


=== 4. Fatigue ===
=== 4. Fatigue ===
Patients with COVID often complain about fatigue. This symptom is one of the most common problems affecting  44-69.6% of individuals with COVID.<ref>Wang D, Hu B, Hu C, et al. [https://jamanetwork.com/journals/jama/fullarticle/2761044 Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China.] JAMA. 2020;323(11):1061–1069.</ref> Factors causing fatigue can be biological, social, behavioural, cognitive and emotional.<ref name=":8">Gaber TA-Z.  [https://wchh.onlinelibrary.wiley.com/doi/10.1002/pnp.698 Assessment and management of post-COVID fatigue]. Progress in Neurology and Psychiatry 2021, 2.Wiley Clinical Healthcare Hub (accessed 29 Oct 2021).
Patients with COVID often complain about fatigue. This symptom is one of the most common problems affecting  44 to 69.6% of individuals with COVID.<ref>Wang D, Hu B, Hu C, et al. [https://jamanetwork.com/journals/jama/fullarticle/2761044 Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China.] JAMA. 2020;323(11):1061–1069.</ref> Factors causing fatigue can be biological, social, behavioural, cognitive and emotional.<ref name=":8">Gaber TA-Z.  [https://wchh.onlinelibrary.wiley.com/doi/10.1002/pnp.698 Assessment and management of post-COVID fatigue]. Progress in Neurology and Psychiatry 2021, 2.Wiley Clinical Healthcare Hub (accessed 29 Oct 2021).


</ref> Others include immune system alteration (immune dysregulation).
</ref> Others include immune system alteration (immune dysregulation).


[[Chronic Fatigue Syndrome]] (CFS) is a problem with a lack of endurance that is persistent and lasts over six months.
* [[Myalgic Encephalomyelitis or Chronic Fatigue Syndrome|Chronic fatigue syndrome]] (CFS) is a problem associated with a lack of endurance that is persistent and lasts over six months.


==== Assessment Tools ====
==== Assessment Tools ====
[[Fatigue Severity Scale|Fatigue]] can be assessed using various tests and scales. [https://watermark.silverchair.com/kqu168.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsYwggLCBgkqhkiG9w0BBwagggKzMIICrwIBADCCAqgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMPwg9F5E1VbAVtbuLAgEQgIICecu8f3KltF8msatW6hyONzJo7IqzSOdIbcm79Jry4e1x4YcnYlTt_NJ2tuiAQozBar4HQVM1THtc_VRlmp1ItJp0NWZpopBDVx-NKVQxkCX1xumkcxj7QPKrejI8aUjJN-DxowsKshLG9hOkXzkQmBV98_npYMJgG6-JrI-hAZTNnHdiXbG6nkaqkPeTUyuTNH7tMX1Jho2rNfJwP4p4HEGJTFyFlNG_zC7kyVFK_pNcuzAkRA4JDAp0nAnq0gCcBQcM8GE3NYzdThR9BVWLaBMM7KqIN0oUuwb5Pz3VNLjzmbTMK8JsROpXvsstsu7WkjEsSJhD8qJMOPnQr2-vmJbihv9wQwDBA5xX92k_j8I1OQn_H5hAvV3_TXA0jKdBVEHnFWlpTS7m9UnxL97bLHabTomZTNvB97_zokKpKOiHCxuRIpxj4QKBBS3RI3bPbmWmB1HckbKK7RV_z-0i6Q8TXo0ZmzXmJlaAXf5ydCFwODLRNiNdsF496VLo_qvipcjKOEg6i3fZUK7E8EQAYp8rvEmkOohLdHNAygTBxnMe9n-hCw_nh2elgLl3KYadg3uTdfJVR0fGbikBjkJOTT6rkdq6YVuO_q6zb_iZN8HNuanKbqVdrtKJww3cjxGQx898GzJrMvySZ-NgKOte6hNZ3hTlHKdIb-BqMiT4bPr_rnD30Ed-k51fzIDeqP507y5mTQqBpGGa9cx2CQ-lar8KfIZecUbRrdL34aVxM_U_SpaFYllhF-2YWUhEbfh8P3ZBIHgqMge46c4wmbFkXLHmKkJsxhgdXAbU8xsz3Ran2t70ofNmTQ24Mn1wRLHas_EUNMmCcwu5Yw Chalder Fatigue Scale] (CFQ-11) is a validated tool where patients responses are measured on a Likert scale.<ref>Townsend L, Dyer AH, Jones K, Dunne J, Mooney A, et al. [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240784 Persistent fatigue following SARS-CoV-2 infection is common and independent of the severity of initial infection.] PLOS ONE 2020;15(11): e0240784.</ref> Pattern and character of fatigue must be evaluated in addition to exercise tolerance and cognitive exertion.
[[Fatigue Severity Scale|Fatigue]] can be assessed using various tests and scales. The [https://watermark.silverchair.com/kqu168.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsYwggLCBgkqhkiG9w0BBwagggKzMIICrwIBADCCAqgGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMPwg9F5E1VbAVtbuLAgEQgIICecu8f3KltF8msatW6hyONzJo7IqzSOdIbcm79Jry4e1x4YcnYlTt_NJ2tuiAQozBar4HQVM1THtc_VRlmp1ItJp0NWZpopBDVx-NKVQxkCX1xumkcxj7QPKrejI8aUjJN-DxowsKshLG9hOkXzkQmBV98_npYMJgG6-JrI-hAZTNnHdiXbG6nkaqkPeTUyuTNH7tMX1Jho2rNfJwP4p4HEGJTFyFlNG_zC7kyVFK_pNcuzAkRA4JDAp0nAnq0gCcBQcM8GE3NYzdThR9BVWLaBMM7KqIN0oUuwb5Pz3VNLjzmbTMK8JsROpXvsstsu7WkjEsSJhD8qJMOPnQr2-vmJbihv9wQwDBA5xX92k_j8I1OQn_H5hAvV3_TXA0jKdBVEHnFWlpTS7m9UnxL97bLHabTomZTNvB97_zokKpKOiHCxuRIpxj4QKBBS3RI3bPbmWmB1HckbKK7RV_z-0i6Q8TXo0ZmzXmJlaAXf5ydCFwODLRNiNdsF496VLo_qvipcjKOEg6i3fZUK7E8EQAYp8rvEmkOohLdHNAygTBxnMe9n-hCw_nh2elgLl3KYadg3uTdfJVR0fGbikBjkJOTT6rkdq6YVuO_q6zb_iZN8HNuanKbqVdrtKJww3cjxGQx898GzJrMvySZ-NgKOte6hNZ3hTlHKdIb-BqMiT4bPr_rnD30Ed-k51fzIDeqP507y5mTQqBpGGa9cx2CQ-lar8KfIZecUbRrdL34aVxM_U_SpaFYllhF-2YWUhEbfh8P3ZBIHgqMge46c4wmbFkXLHmKkJsxhgdXAbU8xsz3Ran2t70ofNmTQ24Mn1wRLHas_EUNMmCcwu5Yw Chalder Fatigue Scale] (CFQ-11) is a validated tool where patients' responses are measured on a Likert scale.<ref>Townsend L, Dyer AH, Jones K, Dunne J, Mooney A, et al. [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240784 Persistent fatigue following SARS-CoV-2 infection is common and independent of the severity of initial infection.] PLOS ONE 2020;15(11): e0240784.</ref> Pattern and character of fatigue must be evaluated in addition to exercise tolerance and cognitive exertion.


Common tests include routine haematology and biochemistry  with full blood count, urea and electrolytes, thyroid function tests, liver function tests, bone profile, erythrocyte sedimentation rate and vitamin B12.<ref name=":8" />  
Common tests include routine haematology and biochemistry  with full blood count, urea and [[Electrolytes|electrolyte]]<nowiki/>s, thyroid function tests, [[Liver Function Tests|liver function tests]], bone profile, erythrocyte sedimentation rate and vitamin B12.<ref name=":8" />  


<div class="row">
<div class="row">
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   <div class="col-md-6"> {{#ev:youtube|muYzcuQoyds|250}} <div class="text-right"><ref>What is a Likert Scale. 4 Expert Tips for Creating a Likert Scale.  Available from: http://www.youtube.com/watch?v=muYzcuQoyds [last accessed 29/10/2021]</ref></div></div>
   <div class="col-md-6"> {{#ev:youtube|muYzcuQoyds|250}} <div class="text-right"><ref>What is a Likert Scale. 4 Expert Tips for Creating a Likert Scale.  Available from: http://www.youtube.com/watch?v=muYzcuQoyds [last accessed 29/10/2021]</ref></div></div>
</div>
</div>
==== Clinical Management ====
==== Clinical Management ====


Lack of evidence-based management strategy for COVID fatigue necessitates the use of treatment methods developed for the management of chronic fatigue syndrome.<ref name=":8" /> This approach includes:
A lack of an evidence-based management strategy for [[Long COVID|COVID fatigue]] necessitates using treatment methods developed to manage chronic fatigue syndrome.<ref name=":8" /> This approach includes:


* educating the patient
* Educating the patient
* improving quality of rest
* Improving the quality of rest (see [[Sleep Deprivation and Sleep Disorders|sleep deprivation and sleep disorders)]]
* choosing activities that do not exacerbate symptoms
* Choosing activities that do not exacerbate symptoms
* learning energy conservation and relaxation techniques
* Learning [[Energy Conservation Techniques|energy conservation]] and relaxation techniques eg [[meditation]]
* learning pacing techniques
* Learning pacing techniques
* incorporating cognitive behavioural therapy (CBT).<br />
* Incorporating [[Cognitive Behavioural Therapy|cognitive behavioural therapy]] (CBT)<br />


== References ==
== References ==


<references />
<references />
[[Category:Physioplus Content]]
[[Category:Plus Content]]
[[Category:COVID-19]]
[[Category:COVID-19]]
[[Category:Course Pages]]
[[Category:Course Pages]]
[[Category:Older People/Geriatrics]]
[[Category:Older People/Geriatrics]]
[[Category: Communicable Diseases]]

Latest revision as of 17:55, 26 February 2023

Original Editor - Ewa Jaraczewska based on the course by Scott Buxton
Top Contributors - Ewa Jaraczewska, Lucinda hampton, Tarina van der Stockt, Wanda van Niekerk, Kim Jackson, Jess Bell, Oyemi Sillo, Olajumoke Ogunleye and Aminat Abolade

Introduction[edit | edit source]

The COVID-19 pandemic shows how vulnerable elderly persons are and that the low capacity of the immune system leads to a fatal outcome. Quick implementation of preventive and therapeutic strategies was not possible due to the worldwide nature of COVID.   Protection of those at risk who already carried the load of other health issues was limited.

COVID in the Elderly[edit | edit source]

Older adults are more likely to experience complications of COVID-19 than younger adults. Older adults with COVID-19 might need hospitalization, intensive care, or a ventilator to help them breathe and increase their chances of survival. The risk rises for people in their 50s and escalates in the 60s, 70s, and 80s. People 85 and older are the most likely to get very sick[1]. It affects people of all ages everywhere in the world, but most deaths from this disease occur in the elderly. The most susceptible individuals 65 years and older are those suffering two or more comorbidities. Furthermore, elderly with a history of cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, malignancy and chronic kidney disease are most at risk of dying from COVID.[2] Additional factors include disabilities, cognitive and mood disorders (eg depression, bipolar), polypharmacotherapy, social isolation, and nutritional deficits often present in the residents of long-term care facilities.[3]

[4]
[5]

Infection and the Elderly[edit | edit source]

Inflammaging.jpeg

The immune system is responsible for overcoming infections due to the production of IgG anti-virus antibodies. The immune system's effectiveness can be influenced by several factors, including nutritional deficits in the elderly. This can lead to severe inflammatory disease affecting the heart, lungs, kidneys and vascular system.[6]

Cells' capacity to respond to infections is defined by the senescence process that begins when cells are dividing but not dying.[7] Cells division is a natural cell ageing process, yet their resistance to death can lead to age-related pathologies. The accumulation of old (senescence) cells in various tissues can be responsible for cells' unnecessary damage.[8]Changes in the development and function of the immune system are called immunosenescence.[7] This process can lead to an increased risk for disease development in the elderly.[7]

Inflammaging (chronic low-grade inflammation that develops with advanced age[9]) presents with elevated levels of blood inflammatory markers[9] frequently described in the elderly population and caused by three geriatric conditions: malnutrition, sarcopenia and frailty.[10]

Nutritional Deficits in the Elderly[edit | edit source]

NUTRITION FACTS.jpg

According to a study completed in European hospitals, residential care and community settings[3] nutritional deficits in the elderly can be caused by reduced dietary intake in addition to age-related problems such as malabsorption, increased nutrient losses and augmented metabolic demands.[6] Malnutrition caused by low intake of food high with vitamins, minerals and proteins directly affect the body's immune responses:

  • Low intake of food high in vitamins, especially:
    • Vitamin A: has an important role in the development and functioning of the immune system and increases the efficacy of T-cell-based viral vaccines[11]
    • Vitamin B: affects cell and immune system function and energy metabolism. Deficiency of Vitamin B leads to inflammation[12]
    • Vitamin C: promotes antimicrobial activity and the production of antibodies. Tends to be depleted during infections resulting in coagulopathy[13]
    • Vitamin D: reduces the risk of infections and assists in immune responses[14]
    • Vitamin E: stimulates T-cell function.[15]
  • Low intake of food high in minerals, especially:
    • Zinc: enhances the total number and function of T-cells[12]
    • Iron: both an excess and a deficiency of iron affect the functioning of the immune system[16]
    • Magnesium: co-factor for immunoglobulin synthesis, immune cell adherence, antibody-dependent cytolysis[17]
    • Copper: supports the immune system



Muscle wasting syndrome in the elderly can be the result of the negative net protein balance as shown by research.[18] Inability of the aged person's muscles to synthesise protein in response to anabolic stimuli (diet, exercise) is a characteristic of anabolic resistance. Based on the scientific evidence[18], it is recommended that the elderly person increase protein intake with each meal to effectively stimulate protein synthesis. [18]

The risk of malnutrition can be assessed using the Mini Nutritional Assessment.[19] This tool can identify if the individual is well-nourished, is at risk for malnutrition or is malnourished.

[20]

Sarcopenia[edit | edit source]

Sarcopenia is a disease that originates at the cellular level. Faulty metabolism can be a causative factor, and symptoms include decreased muscle strength and muscle mass. The progressive cellular processes lead to poor outcomes in an individual's strength, mobility, and functional capacity.[21][22] It is considered one of the risk factors for COVID-19; at the same time, hospitalisation with COVID-19 infection may lead to sarcopenia.

Factors that cause and worsen muscle quantity and quality

Clinically, patients with sarcopenia demonstrate compromised function of the respiratory system, immunological, and metabolic systems, among others.[23] Definition for this clinical presentation was revised in 2018 by the European Working Group on Sarcopenia in Older People (EWGSOP2) and is now used internationally for diagnostic purposes.[24]Clinical assessment should follow recommendations published by the International Working Group on Sarcopenia that include:[25]

  • assessment of physical capabilities
  • ruling out sarcopenia in non-ambulatory patients
  • 4 meters usual walking pace test
  • body composition measurement.

The following are the most commonly used physiotherapy assessment tools:[25]

Frailty[edit | edit source]

Screenshot 2021-11-08 at 11.03.54.jpg

Frailty is a risk factor for COVID. An individual with frailty must present with three or more symptoms, including:[26]

A person with two or fewer deficits listed above is considered in the pre-frail stage. An individual with no deficits is identified as robust.[10]

Due to a reduction in 'physiological reserve affecting immune function and adaptation to acute stressors',[10] frailty is considered high risk for mortality, institutionalisation, falls, and hospitalisation.[26]

[27]

Typical Presentation of COVID[edit | edit source]

The European Centre for Disease Prevention and Control (ECDC) conducted the study on clinical characteristics of COVID-19. However, the study indicated that 40% of COVID-19 cases are asymptomatic.[28] The most common symptoms included:

  • Cough
  • Fever
  • Fatigue
  • Myalgia (muscle aches and pain)
  • Headache
  • Loss of smell
  • Nasal obstruction
  • Asthenia (lack of energy, physical weakness)
  • Rhinorrhoea ( nasal discharge)
  • Olfactory and gustatory dysfunction (taste disturbance)
  • Soar throat

Atypical Presentation of COVID in the Elderly[edit | edit source]

With age‐related changes in immunity, COVID may present atypically in the elderly population. [29][30]

1. Hypoactive Delirium[edit | edit source]

There are three motor subtypes of Delirium:[31]

Subtype Clinical Manifestations
Hyperactive Agitation, restlessness, emotional lability, hallucinations
Hypoactive Lethargy, decreased responsiveness, slowed motor skills
Mixed Fluctuation between hyper- and hypoactive symptoms

Hypoactive delirium is the most common subtype of delirium in the geriatric population.[32] The symptoms include lethargy, confusion, and apathy.[33] Because the patient displays no signs of agitation, irritation, anger or aggression, they are often wrongly diagnosed with depression or dementia.[32] Hypoactive delirium is associated with systemic infection aetiologies and has a lower overall burden of delirium symptoms than the other motor subtypes.[34] However, it has been linked to increased mortality risk.[35][36]

Assessment Tools[edit | edit source]

Diagnostic tools to determine a patient's status include standardised testing, information received from the medical record, and reports from the patient's care team: nursing staff and the family. [34]

Standardised tests:

Clinical Management[edit | edit source]

Management of hypoactive delirium includes pharmacological and non-pharmacological approaches.[37]

Non-pharmacological treatment:

  • Reorientation
    • Living room (scheduled activity with occupational therapist, interaction with other patients)
    • Orientation box (clock, diary, information leaflet, radio, TV, music)
    • Circadian rhythm (healthy sleep-wake cycle)
    • MDT (Multidisciplinary Team) and family participation (family staying at night, room filled with family photos, personal items, pillow, blanket)
  • Psychosocial
    • Delirium consultation (consultation by a specialist: nurse practitioner, geriatrician, psychiatrist)
    • Delirium observation screening score (delirium severity measurement: 13 observations)
  • Other

2. Falls[edit | edit source]

Syncope, near syncope, or non-mechanical falls are atypical features of COVID.[38] The aetiology of syncope or near syncope fall can be cardiogenic and non-cardiogenic, including:

The consequences of falls are one of the main causes of disability among the elderly population leading to a reduction in quality of life, loss of independence and limited social functioning.[39]

Assessment Tools[edit | edit source]

Holistic, multidisciplinary assessment should be considered when evaluating elderly patients with COVID who are at risk of falls and should include:

Clinical Management[edit | edit source]

Key principles for clinical management of patients with fall risk are:

  • Education and support for caregivers
  • Close surveillance to ensure patients' adherence to pharmacological treatment[40]
  • Providing access to nutritious food, social and mental health support and information to maintain patients' emotional well-being[41]
  • Early planning of post-discharge care

3. Anorexia of Ageing[edit | edit source]

Anorexia is a loss of appetite due to the ageing process[42], and it can lead to:

  • Decrease oral intake
  • Weight loss
  • Increased risk of malnutrition
  • Sarcopenia  
  • Frailty[42]  

It is a condition present among the elderly living in all environments. It affects patients admitted to acute care hospitals the most (42%). 30% of individuals living in care homes and 22% of community-dwelling elderly individuals have been diagnosed with anorexia.[43] Pathogenesis of the anorexia of ageing has a direct relationship with changes occurring in three "regulators" of appetite: physiological signalling, hedonism and external cues.[42]

Anorexia was diagnosed in 8.4% of the elderly with COVID-19, and the mortality rate was high due to malnutrition.[44]

Assessment Tools[edit | edit source]

Standardised tools for assessing appetite are not yet available.[42]

The most commonly used appetite assessment instruments are [45]

Clinical Management[edit | edit source]

When managing an individual with a poor appetite, medical causes need to be ruled out first. Medical conditions known to affect appetite are:

  • Chronic heart disease
  • Chronic pulmonary disease
  • Chronic pain disease
  • Acute inflammatory illness
  • Medication side effects
  • Swallowing deficits (dysphagia).[42]

If no medical causes are identified, there is a lack of evidence-based treatments to manage anorexia. It is suggested that the treatment plan should include the following:

  • Nutritional recommendations
  • Oral nutritional supplements (ONS)
  • Psychological support
  • Family-based therapy

4. Fatigue[edit | edit source]

Patients with COVID often complain about fatigue. This symptom is one of the most common problems affecting 44 to 69.6% of individuals with COVID.[46] Factors causing fatigue can be biological, social, behavioural, cognitive and emotional.[47] Others include immune system alteration (immune dysregulation).

  • Chronic fatigue syndrome (CFS) is a problem associated with a lack of endurance that is persistent and lasts over six months.

Assessment Tools[edit | edit source]

Fatigue can be assessed using various tests and scales. The Chalder Fatigue Scale (CFQ-11) is a validated tool where patients' responses are measured on a Likert scale.[48] Pattern and character of fatigue must be evaluated in addition to exercise tolerance and cognitive exertion.

Common tests include routine haematology and biochemistry with full blood count, urea and electrolytes, thyroid function tests, liver function tests, bone profile, erythrocyte sedimentation rate and vitamin B12.[47]

[49]
[50]

Clinical Management[edit | edit source]

A lack of an evidence-based management strategy for COVID fatigue necessitates using treatment methods developed to manage chronic fatigue syndrome.[47] This approach includes:

References[edit | edit source]

  1. ↑ CDC Covid 19 risks and the elderly Available:https://www.cdc.gov/aging/covid19/covid19-older-adults.html (accessed 23.8.2022)
  2. ↑ Emami A, Javanmardi F, Pirbonyeh N, Akbari A. Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis. Arch Acad Emerg Med. 2020 Mar 24;8(1):e35.
  3. ↑ 3.0 3.1 3.2 Leij-Halfwerk S, Verwijs MH, van Houdt S, Borkent JW, Guaitoli PR, Pelgrim T, Heymans MW, Power L, Visser M, Corish CA, de van der Schueren MAE; MaNuEL Consortium. Prevalence of protein-energy malnutrition risk in European older adults in the community, residential and hospital settings, according to 22 malnutrition screening tools validated for use in adults ≥65 years: A systematic review and meta-analysis. Maturitas. 2019 Aug;126:80-89.
  4. ↑ Dr. Maria van Kerkhove. WHO's Science in 5 on COVID-19. Available from: http://www.youtube.com/watch?v=_1s7__6CjtM [last accessed 29/10/2021]
  5. ↑ ABC 10 News. In-Depth Why COVID-19 hits older people hard. Available from: http://www.youtube.com/watch?v=ul0nw5iAuKM [last accessed 29/10/2021]
  6. ↑ 6.0 6.1 Bencivenga L, Rengo G, Varricchi G. Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition. GeroScience 2020, 42; 1089–1092.
  7. ↑ 7.0 7.1 7.2 Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A. Cellular Senescence: Aging, Cancer, and Injury. Physiological Reviews 2019; 99(2): 1047-1078.
  8. ↑ Ahmed AS, Sheng MH, Wasnik S, Baylink DJ, Lau KW. Effect of ageing on stem cells. World J Exp Med. 2017 Feb 20;7(1):1-10.
  9. ↑ 9.0 9.1 Ferrucci L, Fabbri E. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018 Sep;15(9):505-522.
  10. ↑ 10.0 10.1 10.2 Lengelé L, Locquet M, Moutschen M, Beaudart C, Kaux JF, Gillain S, Reginster JY, Bruyère O. Frailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults. Aging Clin Exp Res. 2021 Oct 23:1–12.
  11. ↑ Huang Z, Liu Y, Qi G, Brand D, Zheng S. Role of vitamin A in the immune system. J Clin Med. 2018;7:258
  12. ↑ 12.0 12.1 Shakoor H, Feehan J, Al Dhaheri AS, Ali HI, Platat C, Ismail LC, Apostolopoulos V, Stojanovska L. Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas. 2021 Jan;143:1-9.
  13. ↑ Carr AC. A new clinical trial to test high-dose vitamin C in patients with COVID-19. Crit Care. 2020;24:133.
  14. ↑ Jakovac H. COVID-19 and vitamin D-Is there a link and an opportunity for intervention? Am J Physiol Endocrinol Metab. 2020;318:E589.
  15. ↑ Lee GY, Han SN. The role of vitamin E in immunity. Nutrients. 2018;10.
  16. ↑ Cherayil BJ. Iron and immunity: immunological consequences of iron deficiency and overload. Arch Immunol Ther Exp (Warsz). 2010 Dec;58(6):407-15.
  17. ↑ Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003 Oct;57(10):1193-7.
  18. ↑ 18.0 18.1 18.2 Breen L, Phillips S.M. Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing. Nutr Metab (Lond) 2011; 8 (68).
  19. ↑ Vellas B, Guigoz Y, Garry PJ, Nourhashemi F, Bennahum D, Lauque S, Albarede JL. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition. 1999 Feb;15(2):116-22.
  20. ↑ Prof Janice Thompson. Busting myths about COVID-19 and nutrition. Available from: http://www.youtube.com/watch?v=_yBx0GVO9vo [last accessed 29/10/2021]
  21. ↑ Tarantino U, Piccirilli E, Fantini M, Baldi J, Gasbarra E, Bei R. State of Fragility Fractures Management during the COVID-19 Pandemic. J Bone Joint Surg Am. 2015 Mar 4; 97(5):429-37.
  22. ↑ Moreira VG, Perez M, Lourenço RA. Prevalence of sarcopenia and its associated factors: the impact of muscle mass, gait speed, and handgrip strength reference values on reported frequencies. Clinics (Sao Paulo). 2019 Apr 8;74:e477.
  23. ↑ Wang PY, Li Y, Wang Q. Sarcopenia: An underlying treatment target during the COVID-19 pandemic. Nutrition. 2021 Apr;84:111104.
  24. ↑ Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169. Erratum in: Age Ageing. 2019 Jul 1;48(4):601.
  25. ↑ 25.0 25.1 Cooper C, Fielding R, Visser M, van Loon LJ, Rolland Y, Orwoll E, Reid K, Boonen S, Dere W, Epstein S, Mitlak B, Tsouderos Y, Sayer AA, Rizzoli R, Reginster JY, Kanis JA. Tools in the assessment of sarcopenia. Calcif Tissue Int. 2013 Sep;93(3):201-10.
  26. ↑ 26.0 26.1 Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al.Frailty in Older Adults: Evidence for a Phenotype. The Journals of Gerontology 2001: Series A 56(3): M146–M157.
  27. ↑ Dr Ken Rockwood speaks about frailty and COVID-19. Available from: http://www.youtube.com/watch?v=UT_T2I3p5GI [last accessed 29/10/2021]
  28. ↑ European Centre for Disease Prevention and Control. Available from https://www.ecdc.europa.eu/en/covid-19/latest-evidence/clinical (accessed 19 Oct 2022).
  29. ↑ Soysal P, Kara O. Delirium as the first clinical presentation of the coronavirus disease 2019 in an older adult. Psychogeriatrics. 2020 Sep;20(5):763-765.
  30. ↑ Rawle M, Bertfield D, Brill S. (2020). Atypical presentations of COVID‐19 in care home residents presenting to secondary care: A UK single centre study. AGING MEDICINE 2020. https://onlinelibrary.wiley.com/doi/10.1002/agm2.12126. (Accessed 29 Oct 2021)
  31. ↑ Lipowski ZJ. Transient cognitive disorder in the elderly. Am J Psychiatry 1982;140:1426–36.
  32. ↑ 32.0 32.1 Soysal P, Ahmet TI.Hypoactive delirium caused by pulmonary embolus in an elderly adult. J Am Geriatr Soc. 2014 Mar;62(3):586-7.
  33. ↑ Meagher DJ, Leonard M, Donnelly S, Conroy M, Adamis D, Trzepacz PT. A longitudinal study of motor subtypes in delirium: relationship with other phenomenology, aetiology, medication exposure and prognosis. J Psychosom Res. 2011 Dec;71(6):395-403.
  34. ↑ 34.0 34.1 Glynn K, McKenna F, Lally K, et al. How do delirium motor subtypes differ in phenomenology and contributory aetiology? a cross-sectional, multisite study of liaison psychiatry and palliative care patients. BMJ Open 2021;11:e041214.
  35. ↑ Yang FM, Marcantonio ER, Inouye SK, et al. Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis. Psychosomatics 2009;50:248–54.
  36. ↑ Jackson TA, Wilson D, Richardson S, et al. Predicting outcome in older hospital patients with delirium: a systematic literature review. Int J Geriatr Psychiatry 2016;31:392–9.
  37. ↑ van Velthuijsen EL, Zwakhalen SMG, Mulder WJ, Verhey FRJ, Kempen GIJM. Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice. Int J Geriatr Psychiatry. 2018 Nov;33(11):1521-1529.
  38. ↑ Chen T, Hanna J, Walsh EE, Falsey AR, Laguio-Vila M, Lesho E. Syncope, Near Syncope, or Nonmechanical Falls as a Presenting Feature of COVID-19. Ann Emerg Med. 2020 Jul;76(1):115-117.
  39. ↑ Gawronska K, Lorkowski J. Falls as One of the Atypical Presentations of COVID-19 in Older Population. Geriatric Orthopaedic Surgery & Rehabilitation. January 2021.
  40. ↑ Bianchetti A, Bellelli G, Guerini F. et al. Improving the care of older patients during the COVID-19 pandemic. Aging Clin Exp Res 2020; 32:1883–1888.
  41. ↑ Cudjoe TKM, Kotwal AA. "Social Distancing" Amid a Crisis in Social Isolation and Loneliness. J Am Geriatr Soc. 2020 Jun;68(6):E27-E29.
  42. ↑ 42.0 42.1 42.2 42.3 42.4 42.5 Cox NJ, Morrison L, Ibrahim K, Robinson SM, Sayer AA, Roberts HC. New horizons in appetite and the anorexia of ageing. Age and Ageing 2020; 49(4): 526–534
  43. ↑ van der Meij BS, Wijnhoven HAH, Lee JS et al.  Poor appetite and dietary intake in community-dwelling older adults. J Am Geriatr Soc 2017; 65: 2190–7.
  44. ↑ Neumann-Podczaska A, Al-Saad SR, Karbowski LM, Chojnicki M, Tobis S, Wieczorowska-Tobis K. COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review. Aging Dis. 2020 Jul 23;11(4):988-1008.
  45. ↑ Molfino A, Kaysen GA, Chertow GM, Doyle J, Delgado C, Dwyer T, Laviano A, Rossi Fanelli F, Johansen KL. Validating Appetite Assessment Tools Among Patients Receiving Hemodialysis. J Ren Nutr. 2016 Mar;26(2):103-10
  46. ↑ Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–1069.
  47. ↑ 47.0 47.1 47.2 Gaber TA-Z. Assessment and management of post-COVID fatigue. Progress in Neurology and Psychiatry 2021, 2.Wiley Clinical Healthcare Hub (accessed 29 Oct 2021).
  48. ↑ Townsend L, Dyer AH, Jones K, Dunne J, Mooney A, et al. Persistent fatigue following SARS-CoV-2 infection is common and independent of the severity of initial infection. PLOS ONE 2020;15(11): e0240784.
  49. ↑ What is Chronic Fatigue Syndrome. Available from: http://www.youtube.com/watch?v=5XEMqDa92RA [last accessed 29/10/2021]
  50. ↑ What is a Likert Scale. 4 Expert Tips for Creating a Likert Scale. Available from: http://www.youtube.com/watch?v=muYzcuQoyds [last accessed 29/10/2021]
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