Acute Kidney Injury

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Introduction[edit | edit source]

Acute kidney injury (AKI):

  • A sudden (within hours) decline in kidney function, which includes both injury (structural damage) and impairment (loss of function)[1].
  • Often referred to as acute renal failure (ARF), is a sudden episode of kidney damage or failure that occurs within a few hours or days [2]and is indicated by a sharp rise in serum creatinine, a decline in urine output, or both.
  • AKI is known to occur in between 10% and 15% of hospitalized patients, with more than 50% of patients need intensive care[3].
  • AKI is distinct from chronic kidney disease, which causes the kidneys to slowly lose function over time[4].

Epidemiology[edit | edit source]

Etiology[edit | edit source]

References[edit | edit source]

  1. Makris K, Spanou L. Acute kidney injury: definition, pathophysiology and clinical phenotypes. The clinical biochemist reviews. 2016 May;37(2):85.
  2. Acute Kidney Injury (AKI). Available: https://www.kidney.org/atoz/content/AcuteKidneyInjury (accessed 22.04.2023)
  3. Ronco C, Bellomo R, Kellum JA. Acute kidney injury. The Lancet. 2019 Nov 23;394(10212):1949-64.
  4. Acute kidney injury. Available: https://www.nhs.uk/conditions/acute-kidney-injury/#:~:text=Acute%20kidney%20injury%20(AKI)%20is,as%20the%20name%20might%20suggest. (accessed 22.04.2023)