Acute Coronary Syndrome

Welcome to Glasgow Caledonian University Cardiorespiratory Therapeutics Project This project is created by and for the students in the School of Physiotherapy at Glasgow Caledonian University. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!

Original Editors - Students from Glasgow Caledonian University's Cardiorespiratory Therapeutics Project.

Top Contributors - Haseel Bhatt, Kim Jackson, Lucinda hampton, Adam Vallely Farrell, Admin, Michelle Lee, 127.0.0.1 and WikiSysop  

Definition/Description

Acute coronary syndromes (ACSs) is among a number of medical issues that can be derived from atherothrombosis, includingunstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI). There are approximately 785 000 new events, 470 000 recurrent events, and 195 000 events every year, many of which people are unaware they are in danger. Both spontaneous and percutaneous coronary intervention (PCI)-induced atherosclerotic plaque rupture are capable of initiating the atherothrombotic process. The following platelet response to an injury of a vascular nature is vital and, "is characterized by adhesion of circulating platelets to the vascular endothelium, subsequent activation and aggregation of platelets, and potential obstruction of the intravascular lumen." (ART 2)

Epidemiology

"Acute coronary syndromes (ACS) are the leading cause of death in older adults, aged 65 years or older". (ART 1)

It is projected that hospilitizations of ACS will increase from 1.29 million cases in 2012 to 1.43 million cases in 2022 at the rate of 1.04% per year. 40% of the people reported with ACS are US citizens. 58.15% of the cases occur among the male population and in those ages 65 years annd older make up 69.01%. 33% of the ACS cases were STEMI, 44% were NSTEMI, and 23% were UA. (ART 6)

People 65 years and older who present without chest pain are more likely to die in the hospital compared with ones aged younger than 65 years with chest pain. In fact, older women with chest pain or discomfort are twice as likely to die in the hospital compared with younger women with the same complaint, 13% vs 3.7%. Similarly, older men with chest pain are twice as likely to die in the hospital as men aged younger than 65 years with chest pain, 6.6% vs 2.4%. (art 1) 

Older women with ACS who present without chest pain are 6x more likley to die in hospital compared to women less than age 65 years with chest pain, 21.2% vs 3.7%. Furthermore, older men without chest pain are more likely to die in the hospital compared with men aged younger than 65 years with chest pain, 22% vs 2.4%. (art 1)

Aetiology

Vascular injury and thrombus formation are key components in the initiation and progression of atherosclerosis and in pathogenesis of acute coronary syndrome ). Atherosclerotic plaque formation occurs as a result of damage to the endothelium of the blood vessel. The damaged endothelium stimulates a cascade of inflammatory events that causes macrophages to digest low-density lipoprotein (LDL) transforming into foam cells and causing formation of fatty streaks in the subendothelium . Several coronary risk factors can influence this process, including hypercholesterolemia, hypertension, diabetes, and smoking . ACS takes place when a disrupted atherosclerotic plaque in a coronary artery stimulates platelet aggregation and thrombus formation. Previous research has suggested that the narrowing of the coronary artery causes a decrease in blood flow and ultimately ischemia, however, recent studies have suggested that the rupture of an unstable atherosclerotic plaque is chiefly responsible for thrombus formation and infarction. Autopsy studies have shown that plaque rupture causes approximately 75% of fatal myocardial infarction in comparison to superficial endothelial erosions which account for only 25% (Davies, 1990).

Investigations

Imaging Techniques

Echocardiography

• Echocardiography is highly portable, and relatively inexpensive compared with other noninvasive modalities.
• It on detecting wall motion changes, which occur when myocardial blood flow falls below resting levels. Often this occurs when coronary obstruction exceeds 85–90% of the luminal area.
• Echocardiography is a class I indication to evaluate RWMA in patients presenting with chest pain but with low-to-intermediate risk. (Art 3)

Computed Tomography

• MDCT has the ability to identify plaque area and the degree of stenosis.
  
• The sensitivity of MDCT to detect CAD has been reported to be 73–100% with a specificity of 91–97%. (Art 3)

Cardiac Magnetic Resonance Imaging

• CMR has clear roles in the congenital heart disease, chronic CAD, myocardial and pericardial diseases, and imaging of the great vessels.
• It has a sensitivity of 84% and a specificity of 85%, which is greater than EKG or troponin
• Cine imaging can assess global and regional left ventricular function, and its accurate and reproducible ventricular volumes and functions make it more accurate than other noninvasive methods
• First pass myocardial perfusion utilizes a contrast agent coadministered with a vasodilator-like adenosine to delineate under perfused areas highlighting subendocardial ischemia. (Art 3)

Positron Emission Tomography

• PET is able to identify functional metabolic activity by imaging glucose utilization.
• Fluorodeoxyglucose (FDG) once injected is taken up by cells that utilize glucose for metabolism, and the more metabolic activity of the tissue the greater the amount of FDG, taken up. As FDG decays gamma rays are emitted and the position of origin is imaged by PET imaging.
• Imaging with PET in ACS relies on the ability to detect acute inflammation. Atherosclerotic coronary plaques are characterized by macrophage accumulation. FDG uptake is increased in these areas as macrophages often take up more glucose than the surrounding tissues. (Art 3)

Single Photon Emission Computed Tomography

• SPECT utilizes myocardial perfusion imaging to asses arterial health
• Resting and stress myocardial perfusion imaging in patients with low-to-intermediate risk for CAD will identify active inducible ischemia.
• However, in patients with recent angina symptoms SPECT may not be able to identify recent and old infarcts limiting its specificity.
• SPECT is more sensitive than exercise treadmill testing alone for detecting coronary artery stenosis of >50% (art 3)
  

Clinical Manifestations

The extent to which a coronary artery is occluded often correlates with presenting symptoms and diagnostic findings. Angina or chest pain is considered the cardinal symptom of ACS. Other symptoms that are commonly associated with ACS include; pain with or without radiation to left arm, neck, back or epigastric area, shortness of breath (SOB), diaphoresis, nausea and light headedness. It is important to note that women often present with atypical symptoms which may ultimately delay diagnosis and treatment. These clinical manifestations include; fatigue, lethargy, indigestion, anxiety and pain radiating down the back.

Physiotherapy and Other Management

Reperfusion therapy
"Diagnosis of STEMI requires emergent reperfusion therapy to restore normal blood flow through coronary arteries and limit infarct size. Randomized trials performed at high-volume institutions compared fibrinolysis therapy to percutaneous intervention (PCI) for STEMI. PCI is associated with reduced mortality (30%) and reinfarction rates compared to fibrinolytic drug therapy and decreased risk of intracranial hemorrhage and stroke, which makes it the best choice for elderly and those at risk for bleeding. In optimal circumstances, the usage of PCI is able to achieve restored coronary artery flow in >90% of subjects. Fibrinolytics restores normal coronary artery flow in 50–60% of subjects.

PCI is treatment of choice for STEMI when door-to-balloon time is <90 min by skilled provider in a skilled facility. PCI may also be an option for patients who arrive at a non-PCI hospital and transfer time to a PCI hospital with effective balloon time of <90 min. Transferring patients instead of more immediate fibrinolytic therapy has the combined death rate, nonfatal MI, and stroke rates reduced by 42% when the mean transfer to PCI time is less than 80–122 min. When delays are expected, the physician must consider fibrinolytics if the patient is an appropriate candidate, because delays negate the benefit of PCI over immediate fibrinolytics."(art 4)

Oxygen
"Supplemental oxygen should be given to patients with signs of breathlessness, heart failure, shock, or an arterial oxyhemoglobin saturation <94%. There is insufficient evidence to support the use of supplemental oxygen without the signs of hypoxemia or heart failure." (art 4)

Nitroglycerin
"Nitroglycerin has beneficial effects during suspected cases of ACS. It dilates the coronary arteries, peripheral arterial bed, and venous capacitance vessels. However, the benefits of nitroglycerin are limited and there is no conclusive evidence to support routine use in cases of ACS. The administration of nitroglycerin should be carefully considered in cases when administration would exclude the use of other helpful medications (beta blockers), and especially in patients with low blood pressures (<90 mmHg systolic or ≥30 mmHg below baseline). Patients with ischemic discomfort receive up to 3 doses (0.4 mg) over 3–5 min intervals, until chest discomfort is relieved or low blood pressure limits its use. Nitroglycerin may be administered intravenously, orally, or topically. Clinicians should be cautious in cases of known inferior wall STEMI and suspected right ventricular involvement because patients require adequate right ventricle preload. A right-sided ECG should be performed to rule out right ventricular ischemia. Patients who have taken a phosphodiesterase inhibitor within the last 24 h to treat erectile dysfunction should not receive nitroglycerin; the contraindication time is extended to 48 h if tadalafil was taken." (art 4)

Anti-Platelet therapy is common management provided by other healthcare professionals. This generally involves the utilzation of medications, predominately in tablet form. These drugs can be aspirin, adenosine diphosphate (ADP)-receptor blockers and aglycoprotein IIb/IIIa inhibitors, among others(ART 2).

Asprin

"Aspirin (acetylsalicylic acid [ASA]) blocks the synthesis of TxA2 from arachadonic acid via its inhibition of the cyclooxygenase (COX) enzyme. It represents the oldest and most studied antiplatelet agent, with early clinical trials in ACS showing consistent benefit over placebo or untreated control for reducing the risk of death and recurrent MI." (ART 2)

Adenosine Diphosphate-Receptor Antagonists

"The joint interaction of ADP with its P2Y1 and P2Y12 receptors not only induces platelet aggregation but also amplifies the platelet response through enhanced secretion of, and response to, platelet agonists such as TxA2 and thrombin.15 Consequently, clopidogrel and other thienopyridines, which specifically and irreversibly inhibit the ADP P2Y12 receptor subtype, have become increasingly important in the management of ACS. Several newer antiplatelet agents also act via P2Y12 antagonism and show promise for assuming greater roles in ACS therapy." (ART2)

Ticlopidine

"Ticlopidine was developed as the original ADP P2Y12 receptor antagonist.16 Clinical trials have shown its superiority over control, and its equivalence to aspirin in the prevention of secondary vascular events in patients with ACS.17,18 The concept of combining ASA and a thienopyridine for ACS management was first assessed using ticlopidine, with several studies in patients with PCI demonstrating the benefit of dual antiplatelet therapy over ASA alone or ASA plus warfarin.19-23 However, ticlopidine is associated with elevated risks of neutropenia and thrombotic thrombocyptopenic purpura (TTP) and is poorly tolerated with associated increases in nausea and vomiting." (ART 2)

"Establishing the benefit of clopidogrel in UA/NSTEMI. The Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) trial was the first large randomized clinical trial to establish the benefit of clopidogrel in secondary prevention. The trial compared clopidogrel (75 mg/d) against ASA (325 mg/d) in 19 185 patients with recent MI, recent ischemic stroke, or established peripheral arterial disease (PAD). There was an observed 8.7% relative risk reduction in patients receiving clopidogrel versus ASA for the composite end point of vascular death, MI, or stroke (5.32% vs 5.83%, P ¼ .04).27 Subgroups of the CAPRIE trial with diabetes mellitus, prior coronary artery bypass graft (CABG) surgery, or prior history of MI or ischemic stroke showed particular benefit with clopidogrel as opposed to aspirin therapy." (ART 2)

Beta blockers
"β-Adrenergic receptor blockers have shown to reduce mortality and decrease infarct size with early intravenous usage and can prevent arrhythmias. β-Blockers reduce myocardial workload and oxygen demand by reducing contractility, heart rate, and arterial blood pressure. Contraindications are moderate to severe left ventricle failure, pulmonary edema, bradycardia, hypotension (systolic blood pressure <100 mmHg), signs of poor peripheral perfusion, second- or third-degree heart block, or reactive airway disease." (art4)

Anticoagulation
"Anticoagulant medications such as unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), or less commonly bivalirudin have been shown to decrease reinfarction following reperfusion therapy and are commonly administered in the spectrum of Acute Coronary Syndrome (ACS) unless contraindicated."(art 4)

Prevention

Acute coronary syndrome can best be prevented by better controlling modifiable risk factors such as; diet, exercise, management of hypertension and diabetes and smoking cessesation. In accordance with the NICE guidelines, clinicians should advise people to eat a Mediterranean-style diet, be physically active for 20-30 minutes a day to the point of slight breathlessness, and provide assistance of smoking cessation interventions. Policy changes have taken effect in Scotland which showed a significant decrease the number of admissions for Acute Coronary Syndrome as a result of the The Smoking, Health and Social Care Act which prohibited smoking in all enclosed public places and workplaces.

Resources

add appropriate resources here

Recent Related Research (from Pubmed)

see tutorial on Adding PubMed Feed

References

see adding references tutorial.