Acute Coronary Syndrome: Difference between revisions
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Background epidemiology to the disease or condition (to include prevalence and incidence as appropriate from a UK or Scottish perspective. (You may want to also look at the disease prevalence across different social economic groups). | Background epidemiology to the disease or condition (to include prevalence and incidence as appropriate from a UK or Scottish perspective. (You may want to also look at the disease prevalence across different social economic groups). | ||
<h2> Aetiology </h2> | |||
<p>Vascular injury and thrombus formation are key components in the initiation and progression of atherosclerosis and in pathogenesis of acute coronary syndrome (Epstein, 1992). Atherosclerotic plaque formation occurs as a result of damage to the endothelium of the blood vessel. The damaged endothelium stimulates a cascade of inflammatory events that causes macrophages to digest low-density lipoprotein (LDL) transforming into foam cells and causing formation of fatty streaks in the subendothelium (Kumar, 2009). Several coronary risk factors can influence this process, including hypercholesterolemia, hypertension, diabetes, and smoking (Kumar, 2009). ACS takes place when a disrupted atherosclerotic plaque in a coronary artery stimulates platelet aggregation and thrombus formation. Previous research has suggested that the narrowing of the coronary artery causes a decrease in blood flow and ultimately ischemia, however, recent studies have suggested that the rupture of an unstable atherosclerotic plaque is chiefly responsible for thrombus formation and infarction. Autopsy studies have shown that plaque rupture causes approximately 75% of fatal myocardial infarction in comparison to superficial endothelial erosions which account for only 25% (Davies, 1990). | |||
The causes of the | </p> | ||
== Investigations == | == Investigations == |
Revision as of 23:17, 19 May 2015
Original Editors - Students from Glasgow Caledonian University's Cardiorespiratory Therapeutics Project.
Top Contributors - Haseel Bhatt, Kim Jackson, Lucinda hampton, Adam Vallely Farrell, Admin, Michelle Lee, 127.0.0.1 and WikiSysop
Definition/Description[edit | edit source]
Definition of the disease or condition
Epidemiology[edit | edit source]
Background epidemiology to the disease or condition (to include prevalence and incidence as appropriate from a UK or Scottish perspective. (You may want to also look at the disease prevalence across different social economic groups).
Aetiology
Vascular injury and thrombus formation are key components in the initiation and progression of atherosclerosis and in pathogenesis of acute coronary syndrome (Epstein, 1992). Atherosclerotic plaque formation occurs as a result of damage to the endothelium of the blood vessel. The damaged endothelium stimulates a cascade of inflammatory events that causes macrophages to digest low-density lipoprotein (LDL) transforming into foam cells and causing formation of fatty streaks in the subendothelium (Kumar, 2009). Several coronary risk factors can influence this process, including hypercholesterolemia, hypertension, diabetes, and smoking (Kumar, 2009). ACS takes place when a disrupted atherosclerotic plaque in a coronary artery stimulates platelet aggregation and thrombus formation. Previous research has suggested that the narrowing of the coronary artery causes a decrease in blood flow and ultimately ischemia, however, recent studies have suggested that the rupture of an unstable atherosclerotic plaque is chiefly responsible for thrombus formation and infarction. Autopsy studies have shown that plaque rupture causes approximately 75% of fatal myocardial infarction in comparison to superficial endothelial erosions which account for only 25% (Davies, 1990).
Investigations[edit | edit source]
This may well include any investigations used to gain a diagnosis or that you might need to gain information about your patient assessment.
Clinical Manifestations[edit | edit source]
Clinical manifestations (the signs and symptoms your patient may well present to you on an examination) ensure you relate this back to the underlying pathophysiology.
Physiotherapy and Other Management[edit | edit source]
Physiotherapy and other management. Other health professionals will be treating your patient. What is their input?
Prevention[edit | edit source]
Brief consideration of how this pathology could be prevented and the physiotherapy role in health promotion in relation to prevention of disease or disease progression.
Resources
[edit | edit source]
add appropriate resources here
Recent Related Research (from Pubmed)[edit | edit source]
see tutorial on Adding PubMed Feed
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References[edit | edit source]
see adding references tutorial.