Gilbert's Syndrome
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Top Contributors - J.Dylan James, Elaine Lonnemann, WikiSysop, Kim Jackson and 127.0.0.1
Definition/Description[edit | edit source]
Gilbert’s syndrome is a benign liver condition that is characterized by elevated levels of bilirubin in the blood.(1,2) Bilirubin is produced by the breakdown of red blood cells and is able to be removed from the body after the liver converts it from unconjugated bilirubin to conjugated bilirubin.(1,3,4) In individuals with Gilbert’s syndrome, there is a buildup of unconjugated bilirubin in the liver as a result of a genetic mutation of the enzyme UDP-glucuronosyltransferase 1A isoform 1 (UGT1A1), which is important in bilirubin metabolism.(4,5) The buildup of bilirubin is particularly evident after starvation, exertion, infection, consumption of alcohol, or dehydration.(5) Bilirubin levels fluctuate and rarely increase to levels that cause jaundice.(1)
Prevalence[edit | edit source]
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Characteristics/Clinical Presentation[edit | edit source]
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Associated Co-morbidities[edit | edit source]
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Etiology/Causes[edit | edit source]
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Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Resources
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