Forestier Disease: Difference between revisions

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== Epidemiology/Etiology  ==
== Epidemiology/Etiology  ==


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Forestier disease (DISH) is most common in the elderly population (&gt;50 years old) and the prevalence increases with age (Mader R 2005(A1), Sarzi-Puttini P 2004(A1)) [1,4]. Although the etiology of the disease is not fully understood, studies have already shown that the clinical features are related to the formation of new bone. It is assumed that several metabolic factors affect the onset of the disease (Holton KF 2011(B), Mader R 2002(C), Sarzi-Puttini P 2004(A1), Westerveld LA 2009(C)) <ref name="2">Holton KF, Diffuse idiopathic skeletal hyperostosis and its relation to back pain among older men: the MrOS Study. Semin Arthritis Rheum 2011, Mar. 3 [Epub ahead of print]  (level B)</ref>&nbsp;<ref name="3">Mader R, Clinical manifestations of diffuse idiopathic skeletal hyperostosis of the cervical spine. Semin Arthritis Rheum 2002, vol 32, no 2, p.130-135 (level C)</ref> <ref name="4" />&nbsp;<ref name="8">Westerveld LA, Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. Eur Spine J 2009, vol.18: p.145-156  (level C)</ref>.


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Etiologic / Risk factors associated with various metabolic conditions <ref name="1" />&nbsp;<ref name="4" /> <ref name="5" />&nbsp;<ref name="8" />:<br> (Mader R 2005(A1), Sarzi-Puttini P 2004(A1), Mader R 2009(A1), Westerveld LA 2009(C))
 
*waist circumference
*BMI / Obesity
*hyperinsulinemia
*[[Diabetes|diabetes mellitus]]
*hyperuricemia
*dyslipidemia
*hypertension
*coronary artery disease
*[[Gout|gout]]<br>&nbsp;<br>


== Characteristics/Clinical Presentation  ==
== Characteristics/Clinical Presentation  ==

Revision as of 23:34, 25 May 2011

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Search Strategy[edit | edit source]

Databases: Pubmed, web of knowledge
Search terms: forestier disease, diffuse idiopathic skeletal hyperostosis, treatment DISH, physical therapy DISH
 

Definition/Description[edit | edit source]

Forestier disease or diffuse idiopathic skeletal hyperostosis is a condition characterized by thickening, calcification and ossification of soft tissues, mainly ligaments, joint capsules and insertions of muscles and tendons (entheses). Another aspect of the disease is the formation of large, flowing osteophytes due to abnormal bone growth (Mader R 2005(A1), Sarzi-Puttini P 2004(A1), Mader R 2009(A1)) Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title. 


These ossifications are mostly seen in the axial skeleton, of which the thoracic region is the main location (Mader R 2005(A1), Mader R 2002(C)) Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title. Also peripheral entheses may be affected: peripatellar ligaments, Achilles tendon insertion, plantar fascia, shoulders, olecranon and metacarpophalangeal joints (Mader R 2005(A1), Sarzi-Puttini P 2004(A1), Mader R 2009(A1)) Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title.


Forestier disease or DISH has also been described by various other names, such as spondylosis hyperostotica, spondylitis ossificans ligamentosa, senile ankylosing hyperostosis and others (Giles LGF 2001) Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title. 
 

Epidemiology/Etiology[edit | edit source]

Forestier disease (DISH) is most common in the elderly population (>50 years old) and the prevalence increases with age (Mader R 2005(A1), Sarzi-Puttini P 2004(A1)) [1,4]. Although the etiology of the disease is not fully understood, studies have already shown that the clinical features are related to the formation of new bone. It is assumed that several metabolic factors affect the onset of the disease (Holton KF 2011(B), Mader R 2002(C), Sarzi-Puttini P 2004(A1), Westerveld LA 2009(C)) Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title.

Etiologic / Risk factors associated with various metabolic conditions Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title Cite error: Invalid <ref> tag; name cannot be a simple integer. Use a descriptive title:
(Mader R 2005(A1), Sarzi-Puttini P 2004(A1), Mader R 2009(A1), Westerveld LA 2009(C))

  • waist circumference
  • BMI / Obesity
  • hyperinsulinemia
  • diabetes mellitus
  • hyperuricemia
  • dyslipidemia
  • hypertension
  • coronary artery disease
  • gout
     

Characteristics/Clinical Presentation[edit | edit source]

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Differential Diagnosis[edit | edit source]

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Diagnostic Procedures[edit | edit source]

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Outcome Measures[edit | edit source]

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Management / Interventions[edit | edit source]

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Key Research[edit | edit source]

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Recent Related Research (from Pubmed)[edit | edit source]

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References[edit | edit source]

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