Oxalosis: Difference between revisions
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== Characteristics/Clinical Presentation == | == Characteristics/Clinical Presentation == | ||
Oxalosis can present with a multitude of symptoms depending upon the severity and progression of the condition. Oxalate crystals can be formed in various bodily structures including the blood, eyes, bones, muscles, heart and other organs. Depending on where the excess accumulation of oxalate is located, patients are going to present differently. If excess oxalate accumulates in the bones, synovium, cartilage, or tendons, pain may present similarly to that of arthropathy (disease of a joint). When oxalate deposits in the synovium of joints, excessive inflammation can procure, often resembling arthralgias (joint pain). The most common joints often affected by systemic Oxalosis are the proximal interphalangeal and metacarpophalangeal joints, knees, elbows and ankles. Excess oxalate crystals in the bones may also present as fractures, or just bone pain. Oxalosis affecting muscles could display as generalized aching or cramping of a muscle. A patient with Oxalosis can present with anemia or with skin ulcers. Due to the fact that the heart can be affected by Oxalosis and higher levels of calcium are circulating in the body, the function of the heart may be hindered. For instance patients with Oxalosis can present with cardiac arrhythmias or with cardiomyopathy. In some cases, oxalosis has been known to affect neural structures. When oxalate deposits around nerves, patients can report sensation abnormalities (tingling, numbness, shooting pain), as well as progressive strength deficits. <br>Hyperoxaluria, the primary cause of Oxalosis, may exhibit many different types of symptoms. Depending on the progression and severity, symptoms may first develop at birth or during adulthood. Although people will present differently depending upon the underlying mechanism for developing the condition, the first sign or symptom of Hyperoxaluria is often the presence of blood or pain during micturition. Other common symptoms that appear during the initial stages of the disease are an infection of the urinary tract or passing of a kidney stone. Although only reported in a minimal number of cases, the presence of the condition may first present as kidney failure. Also, others may not present with overwhelming symptoms initially and may be unaware until the third to fifth decades of life. | |||
== Associated Co-morbidities == | == Associated Co-morbidities == |
Revision as of 01:44, 5 April 2016
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Top Contributors - Oscar Lewis, Lucinda hampton, Shelby Kissel, WikiSysop, 127.0.0.1, Elaine Lonnemann, Tomer Yona and Kim Jackson
Definition/Description[edit | edit source]
Oxalosis is a rare metabolic disorder in which the kidneys are unable to eliminate Calcium Oxalate Crystals through the urine. The excess crystals then collect in other parts of the body, accumulating first in the blood, then the eyes, bones, muscles, blood vessels, heart and other major organs. If untreated Oxalosis can lead to death.
Prevalence[edit | edit source]
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Characteristics/Clinical Presentation[edit | edit source]
Oxalosis can present with a multitude of symptoms depending upon the severity and progression of the condition. Oxalate crystals can be formed in various bodily structures including the blood, eyes, bones, muscles, heart and other organs. Depending on where the excess accumulation of oxalate is located, patients are going to present differently. If excess oxalate accumulates in the bones, synovium, cartilage, or tendons, pain may present similarly to that of arthropathy (disease of a joint). When oxalate deposits in the synovium of joints, excessive inflammation can procure, often resembling arthralgias (joint pain). The most common joints often affected by systemic Oxalosis are the proximal interphalangeal and metacarpophalangeal joints, knees, elbows and ankles. Excess oxalate crystals in the bones may also present as fractures, or just bone pain. Oxalosis affecting muscles could display as generalized aching or cramping of a muscle. A patient with Oxalosis can present with anemia or with skin ulcers. Due to the fact that the heart can be affected by Oxalosis and higher levels of calcium are circulating in the body, the function of the heart may be hindered. For instance patients with Oxalosis can present with cardiac arrhythmias or with cardiomyopathy. In some cases, oxalosis has been known to affect neural structures. When oxalate deposits around nerves, patients can report sensation abnormalities (tingling, numbness, shooting pain), as well as progressive strength deficits.
Hyperoxaluria, the primary cause of Oxalosis, may exhibit many different types of symptoms. Depending on the progression and severity, symptoms may first develop at birth or during adulthood. Although people will present differently depending upon the underlying mechanism for developing the condition, the first sign or symptom of Hyperoxaluria is often the presence of blood or pain during micturition. Other common symptoms that appear during the initial stages of the disease are an infection of the urinary tract or passing of a kidney stone. Although only reported in a minimal number of cases, the presence of the condition may first present as kidney failure. Also, others may not present with overwhelming symptoms initially and may be unaware until the third to fifth decades of life.
Associated Co-morbidities[edit | edit source]
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Etiology/Causes[edit | edit source]
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Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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References[edit | edit source]
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