Osteoblastoma: Difference between revisions
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== Etiology/Causes == | == Etiology/Causes == | ||
Currently unknown.<br> | |||
== Systemic Involvement == | == Systemic Involvement == |
Revision as of 21:46, 21 March 2013
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
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Definition/Description[edit | edit source]
Osteoblastoma is a rare, benign osteoblastic (bone) tumor that most commonly develops in the spine, sacrum, long bones, and flat bones. Benign tumors do not spread to various sites or organs. However, an aggressive type of osteoblastoma has been identified in very rare occasions that have led to metastasis, death, and mimicked osteosarcoma. It is a bone tumor that histologically is very similar to that as an osteoid osteoma, which can make differentiating between the two difficult. Osteoblastoma tumors are typically larger, and have an osteolytic and sclerotic border when viewed on radiographs.
Prevalence[edit | edit source]
Of all benign bone tumors, osteoblastoma only accounts for about 1-2%, being more prevalent in males than females. This more commonly develops in men younger than 30, but can occur in ages as young as 2 and old as 70. Of those diagnosed with osteoblastoma, 80% of them are within the ages of 10 and 30.
Osteosarcomas are 20 times more likely to occur, while osteoid osteomas are 4 times more likely to occur than osteoblastomas.
Characteristics/Clinical Presentation[edit | edit source]
Signs and Symptoms:
• Pain(most common symptom)
o Worsens with time
o Less severe night pain when compared to osteoid osteoma
o NSAIDs do not have an effect on pain levels, like with osteoid osteoma
• Tenderness over the lesion
• Swelling at the lesion
• Bony enlargement over lesion with palpation
• Scoliosis of the spine
• Muscle spasms
• Decreased ROM
• Neurological symptoms secondary to spine lesions causing change in the bony structure
o 50% of those diagnosed with spinal lesions report neurological symptoms
Associated Co-morbidities[edit | edit source]
None.
Medications[edit | edit source]
None.
Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
• X-Ray
- Positive for Osteoblastoma: 4-6cm in size at the lesion, cortical thinning, expansion of bone, radiolucency in the central aspect of the lesion with a thin, sclerotic border, may also have soap bubble appearance and osteolytic expansile lesion similar to that of aneurysmal bone cyst
• CT Scan
• MRI
- CT scan and MRI are both helpful in identifying the lesion and the extent of tissue involved in the lesion
• Bone Scan
- Positive for Osteoblastoma: increase in uptake would be noted
• Bone Biopsy
- Fragment of the bone removed from tumor and sent to lab for diagnostic testing/histological report
• Blood Work – Complete Blood Count (CBC)
- Helpful for differential diagnosis in determining if the lesion is of another form of benign or malignant bony tumor
• Chest X-Ray
- Used for differential diagnosis of osteosarcoma
Etiology/Causes[edit | edit source]
Currently unknown.
Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Alternative/Holistic Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Case Reports/ Case Studies[edit | edit source]
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Resources
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Recent Related Research (from Pubmed)[edit | edit source]
see tutorial on Adding PubMed Feed
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References[edit | edit source]
see adding references tutorial.