Ataxia In Cerebral Palsy: Difference between revisions
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== Mechanism of Injury / Pathological Process<br> == | == Mechanism of Injury / Pathological Process<br> == | ||
Ataxia " is defined as an inability to generate a normal or expected voluntary movement trajectory that cannot be attributed to weakness or involuntary muscle activity about the affected joints.<ref>Sanger TD, Chen D, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW, Taskforce on Childhood Motor Disorders. [https://pubmed.ncbi.nlm.nih.gov/20589866/#:~:text=Abstract,implications%20for%20diagnosis%20and%20treatment. Definition and classification of negative motor signs in childhood]. Pediatrics. 2006 Nov 1;118(5):2159-67.</ref><br> | Ataxia " is defined as an inability to generate a normal or expected voluntary movement trajectory that cannot be attributed to weakness or involuntary muscle activity about the affected joints.<ref>Sanger TD, Chen D, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW, Taskforce on Childhood Motor Disorders. [https://pubmed.ncbi.nlm.nih.gov/20589866/#:~:text=Abstract,implications%20for%20diagnosis%20and%20treatment. Definition and classification of negative motor signs in childhood]. Pediatrics. 2006 Nov 1;118(5):2159-67.</ref> | ||
An important aspect of the cerebellum's function is highlighted by Justus et. al as"... memory processes required for associative learning and adapting of motor functions"<ref>Kebschull JM, Casoni F, Consalez GG, Goldowitz D, Hawkes R, Ruigrok TJ, Schilling K, Wingate R, Wu J, Yeung J, Uusisaari MY. [https://link.springer.com/article/10.1007/s12311-022-01506-0 Cerebellum lecture: the cerebellar nuclei—core of the cerebellum. The Cerebellum]. 2023 Feb 13:1-58. Pg 2</ref> In addition, recent research has also shown the cerebellum's involvement in autonomic, emotional and even cognitive aspects of brain function.<ref>Kebschull JM, Casoni F, Consalez GG, Goldowitz D, Hawkes R, Ruigrok TJ, Schilling K, Wingate R, Wu J, Yeung J, Uusisaari MY. [https://link.springer.com/article/10.1007/s12311-022-01506-0 Cerebellum lecture: the cerebellar nuclei—core of the cerebellum. The Cerebellum]. 2023 Feb 13:1-58.</ref><br> | |||
== Clinical Presentation == | == Clinical Presentation == | ||
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== Diagnostic Procedures == | == Diagnostic Procedures == | ||
Magnetic resonance imaging (MRI) is considered the general standard of diagnosing CP in general.<ref>Arnfield E, Guzzetta A, Boyd R. [https://pubmed.ncbi.nlm.nih.gov/23643774/ Relationship between brain structure on magnetic resonance imaging and motor outcomes in children with cerebral palsy: a systematic review.] Research in Developmental Disabilities. 2013 Jul 1;34(7):2234-50.</ref> However, a study done in 2022 highlighted the fact that despite the 31 CP children enrolled in their study displaying no structural abnormalities on MRI, these children did display abnormalities in terms of cerebral glucose metabolism on PET (position emission tomography) scans. <ref>Wu R, Gao Y, Zhang H, Chen Y, Tan F, Zeng D, Wan H, Yang Y, Gu J, Pei Z. M[https://www.frontiersin.org/articles/10.3389/fneur.2022.844911/full etabolic assessment of cerebral palsy with normal clinical MRI using 18F-FDG PET imaging: A preliminary report]. Frontiers in Neurology. 2022 Sep 15;13:844911.</ref><br> | |||
== Outcome Measures == | == Outcome Measures == | ||
Latest revision as of 21:43, 30 January 2024
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Clinically Relevant Anatomy
[edit | edit source]
add text here relating to clinically relevant anatomy of the condition
Mechanism of Injury / Pathological Process
[edit | edit source]
Ataxia " is defined as an inability to generate a normal or expected voluntary movement trajectory that cannot be attributed to weakness or involuntary muscle activity about the affected joints.[1]
An important aspect of the cerebellum's function is highlighted by Justus et. al as"... memory processes required for associative learning and adapting of motor functions"[2] In addition, recent research has also shown the cerebellum's involvement in autonomic, emotional and even cognitive aspects of brain function.[3]
Clinical Presentation[edit | edit source]
Diagnostic Procedures[edit | edit source]
Magnetic resonance imaging (MRI) is considered the general standard of diagnosing CP in general.[4] However, a study done in 2022 highlighted the fact that despite the 31 CP children enrolled in their study displaying no structural abnormalities on MRI, these children did display abnormalities in terms of cerebral glucose metabolism on PET (position emission tomography) scans. [5]
Outcome Measures[edit | edit source]
add links to outcome measures here (see Outcome Measures Database)
Management / Interventions
[edit | edit source]
add text here relating to management approaches to the condition
Differential Diagnosis
[edit | edit source]
add text here relating to the differential diagnosis of this condition
Resources
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add appropriate resources here
References[edit | edit source]
- ↑ Sanger TD, Chen D, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW, Taskforce on Childhood Motor Disorders. Definition and classification of negative motor signs in childhood. Pediatrics. 2006 Nov 1;118(5):2159-67.
- ↑ Kebschull JM, Casoni F, Consalez GG, Goldowitz D, Hawkes R, Ruigrok TJ, Schilling K, Wingate R, Wu J, Yeung J, Uusisaari MY. Cerebellum lecture: the cerebellar nuclei—core of the cerebellum. The Cerebellum. 2023 Feb 13:1-58. Pg 2
- ↑ Kebschull JM, Casoni F, Consalez GG, Goldowitz D, Hawkes R, Ruigrok TJ, Schilling K, Wingate R, Wu J, Yeung J, Uusisaari MY. Cerebellum lecture: the cerebellar nuclei—core of the cerebellum. The Cerebellum. 2023 Feb 13:1-58.
- ↑ Arnfield E, Guzzetta A, Boyd R. Relationship between brain structure on magnetic resonance imaging and motor outcomes in children with cerebral palsy: a systematic review. Research in Developmental Disabilities. 2013 Jul 1;34(7):2234-50.
- ↑ Wu R, Gao Y, Zhang H, Chen Y, Tan F, Zeng D, Wan H, Yang Y, Gu J, Pei Z. Metabolic assessment of cerebral palsy with normal clinical MRI using 18F-FDG PET imaging: A preliminary report. Frontiers in Neurology. 2022 Sep 15;13:844911.
