Inflammation Acute and Chronic: Difference between revisions

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== Introduction ==
== Introduction ==
Inflammation is part of the body's defense mechanism. It is the process by which the [[Immune System|immune system]] recognizes and removes harmful and foreign stimuli and begins the healing process. Inflammation can be either acute or chronic.
Inflammation is the immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation, and acts by removing injurious stimuli and initiating the healing process. Inflammation is therefore a defense mechanism that is vital to health. During acute inflammatory responses, cellular and molecular events and interactions efficiently minimize impending injury or infection. This process contributes to restoration of tissue homeostasis and resolution of the acute inflammation. Uncontrolled acute inflammation may become chronic, contributing to a variety of chronic inflammatory diseases<ref>Chen L, Deng H, Cui H, et al. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805548/ Inflammatory responses and inflammation-associated diseases in organs]. ''Oncotarget''. 2017;9(6):7204-7218. Published 2017 Dec 14. doi:10.18632/oncotarget.23208 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805548/<nowiki/>(accessed 22.1.2021)</ref>. Inflammation can be hence be either acute or chronic.


'''Acute Inflammation'''
'''Acute Inflammation'''

Revision as of 03:47, 22 January 2021

Original Editor - Lucinda hampton

Top Contributors - Lucinda hampton, Bruno Serra, Rishika Babburu, Temitope Olowoyeye, Kim Jackson, Vidya Acharya and Sehriban Ozmen  

Introduction[edit | edit source]

Inflammation is the immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation, and acts by removing injurious stimuli and initiating the healing process. Inflammation is therefore a defense mechanism that is vital to health. During acute inflammatory responses, cellular and molecular events and interactions efficiently minimize impending injury or infection. This process contributes to restoration of tissue homeostasis and resolution of the acute inflammation. Uncontrolled acute inflammation may become chronic, contributing to a variety of chronic inflammatory diseases[1]. Inflammation can be hence be either acute or chronic.

Acute Inflammation

Tissue damage due to trauma, microbial invasion, or noxious compounds can induce acute inflammation. It starts rapidly, becomes severe in a short time and symptoms may last for a few days eg. cellulitis; acute pneumonia. Subacute inflammation is the period between acute and chronic inflammation and may last 2 to 6 weeks.

Chronic Inflammation

Chronic inflammation is also referred to as slow, long-term inflammation lasting for prolonged periods of several months to years. Generally, the extent and effects of chronic inflammation vary with the cause of the injury and the ability of the body to repair and overcome the damage[2].

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References[edit | edit source]

  1. ↑ Chen L, Deng H, Cui H, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017;9(6):7204-7218. Published 2017 Dec 14. doi:10.18632/oncotarget.23208 Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805548/(accessed 22.1.2021)
  2. ↑ Pahwa R, Jialal I. Chronic inflammation.2019 Available from:https://www.ncbi.nlm.nih.gov/books/NBK493173/ (accessed 21.1.2021)
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