Primary Lateral Sclerosis: Difference between revisions
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'''Original Editor '''- | '''Original Editor '''- John-Carlo Caballes, David Castro, Alana Griffith, Joyce Tan, Joanne Van | ||
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== Definition / Description<br> == | == Definition / Description<br> == | ||
Primary Lateral Sclerosis (PLS) is characterized as being a rare, non-hereditary, idiopathic, slow, and progressive degeneration of the upper motor neurons<ref name="statland et al.">Statland, JM, Barohn, RJ, Dimachkie, MM, Floeter, MK, Mitsumoto, H. Primary lateral sclerosis. Neurol Clin. 2015 Nov;33(4):749-60. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26515619 doi:10.1016/j.ncl.2015.07.007</ref>. PLS lies on a continuum of sporadic motor neuron disorders. This spectrum includes other disorders such as progressive muscular atrophy, which involves only lower motor neurons, as well as amyotrophic lateral sclerosis (ALS), characterized by both upper and lower motor neuron involvement. Many patients diagnosed with PLS continue to have high levels of independence for many years<ref>Gordon, PH, Cheng, B, Katz, IB, Pinto, M, Hays, AP, Mitsumoto, H, Rowland, LP. The natural history of primary lateral sclerosis. Neurology. 2006 Mar;66(5):647-53. doi: 10.1212/01.wnl.0000200962.94777.71</ref>.<br> | Primary Lateral Sclerosis (PLS) is characterized as being a rare, non-hereditary, idiopathic, slow, and progressive degeneration of the upper motor neurons<ref name="statland et al.">Statland, JM, Barohn, RJ, Dimachkie, MM, Floeter, MK, Mitsumoto, H. Primary lateral sclerosis. Neurol Clin. 2015 Nov;33(4):749-60. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26515619 doi:10.1016/j.ncl.2015.07.007</ref>. PLS lies on a continuum of sporadic motor neuron disorders. This spectrum includes other disorders such as progressive muscular atrophy, which involves only lower motor neurons, as well as amyotrophic lateral sclerosis (ALS), characterized by both upper and lower motor neuron involvement. Many patients diagnosed with PLS continue to have high levels of independence for many years<ref>Gordon, PH, Cheng, B, Katz, IB, Pinto, M, Hays, AP, Mitsumoto, H, Rowland, LP. The natural history of primary lateral sclerosis. Neurology. 2006 Mar;66(5):647-53. doi: 10.1212/01.wnl.0000200962.94777.71</ref>.<br> | ||
== Clinically Relevant Anatomy == | |||
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== Epidemiology == | |||
== Etiology == | |||
== Mechanism of Injury / Pathological Process<br> == | == Mechanism of Injury / Pathological Process<br> == | ||
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add text here relating to the clinical presentation of the condition<br> | add text here relating to the clinical presentation of the condition<br> | ||
== Prognosis == | |||
== Diagnostic Procedures == | == Diagnostic Procedures == | ||
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== References | == References<br> == | ||
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Revision as of 02:37, 5 May 2017
Original Editor - John-Carlo Caballes, David Castro, Alana Griffith, Joyce Tan, Joanne Van
Lead Editors
Definition / Description
[edit | edit source]
Primary Lateral Sclerosis (PLS) is characterized as being a rare, non-hereditary, idiopathic, slow, and progressive degeneration of the upper motor neurons[1]. PLS lies on a continuum of sporadic motor neuron disorders. This spectrum includes other disorders such as progressive muscular atrophy, which involves only lower motor neurons, as well as amyotrophic lateral sclerosis (ALS), characterized by both upper and lower motor neuron involvement. Many patients diagnosed with PLS continue to have high levels of independence for many years[2].
Clinically Relevant Anatomy[edit | edit source]
add text here relating to clinically relevant anatomy of the condition
Epidemiology[edit | edit source]
Etiology[edit | edit source]
Mechanism of Injury / Pathological Process
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Clinical Presentation[edit | edit source]
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Prognosis[edit | edit source]
Diagnostic Procedures[edit | edit source]
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Outcome Measures[edit | edit source]
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Management / Interventions
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Differential Diagnosis
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Key Evidence[edit | edit source]
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Resources
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Case Studies[edit | edit source]
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Recent Related Research (from Pubmed)[edit | edit source]
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References
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- ↑ Statland, JM, Barohn, RJ, Dimachkie, MM, Floeter, MK, Mitsumoto, H. Primary lateral sclerosis. Neurol Clin. 2015 Nov;33(4):749-60. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26515619 doi:10.1016/j.ncl.2015.07.007
- ↑ Gordon, PH, Cheng, B, Katz, IB, Pinto, M, Hays, AP, Mitsumoto, H, Rowland, LP. The natural history of primary lateral sclerosis. Neurology. 2006 Mar;66(5):647-53. doi: 10.1212/01.wnl.0000200962.94777.71