Cytomegalovirus (CMV) Infection: Difference between revisions
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== Associated Co-morbidities == | == Associated Co-morbidities == | ||
Cytomegalovirus is often associated with systemic diseases during times of immunosuppression manifesting as:<ref name="Guo" /> | |||
*Hepatitis | |||
*Retinitis | |||
*Colitis | |||
*Pneumonitis | |||
*Esophagitis | |||
*Bone marrow suppression <br> | |||
== Medications == | == Medications == |
Revision as of 01:54, 6 April 2016
Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.
Top Contributors - Elizabeth Levay, WikiSysop, Kim Jackson, Lucinda hampton, 127.0.0.1, Elaine Lonnemann and Nupur Smit Shah
Description[edit | edit source]
Cytomegalovirus (CMV) Infection, also known as herpesvirus type 5, is a common virus belonging to the herpes family that affects a variety of individuals across the lifespan[1]. It is currently the leading cause of congenital infections in the world, and can cause long term consequences such as hearing loss, visual deficits, and cognitive delays[2][3]. It is frequently acquired in late childhood or early adulthood, and is rarely symptomatic, except in the immunocompromised.
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Prevalence[edit | edit source]
Reported incidence of CMV varies. Recent evidence suggests that one percent of newborns have the virus, as well as eighty percent of people over 35 years of age[1]. Other studies report that 50-80% of people are infected with the virus, and up to 90% or more in developing countries[2]. After infection, the virus may remain latent within monocytes, frequently causing it to be difficult to detect[4]. Therefore, true prevalence may be different than numbers reported.
Characteristics/Clinical Presentation[edit | edit source]
Cytomegalovirus rarely presents with symptoms and may be be left undetected. Like other viruses in the herpes family, CMV resides dormant in the body[5]. After dormancy, it can be reactivated by some trigger, which commonly includes immunosuppression, stress, and medication use[4]. When active, individuals with CMV may show signs of lower extremity weakness which can later result in flaccid paralysis due to nerve root damage[1]. Cytomegalovirus can also present with a variety of other symptoms such as:[5][6]
- Cough
- Fatigue
- Fever
- Malaise
- Loss of appetite
- Joint pain
- Shortness of breath
- Dyspnea
- Night sweats
- Rash
- Upper Respiratory Infection
Associated Co-morbidities[edit | edit source]
Cytomegalovirus is often associated with systemic diseases during times of immunosuppression manifesting as:[4]
- Hepatitis
- Retinitis
- Colitis
- Pneumonitis
- Esophagitis
- Bone marrow suppression
Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Etiology/Causes[edit | edit source]
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Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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Case Reports/ Case Studies[edit | edit source]
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Resources
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Recent Related Research (from Pubmed)[edit | edit source]
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References[edit | edit source]
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- ↑ 1.0 1.1 1.2 Goodman C, Snyder T. Differential Diagnosis for Physical Therapists: Screening for Referral. 5th ed. St. Louis, MO: Elsevier; 2013: 336-337.
- ↑ 2.0 2.1 Cytomegalovirus (CMV). https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv (accessed 04 March 2016).
- ↑ Dollard S, Grosse S, Ross D. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Reviews In Medical Virology [serial on the Internet]. (2007, Sep), [cited April 4, 2016]; 17(5): 355-363. Available from: MEDLINE.
- ↑ 4.0 4.1 4.2 Guo R, Gebreab F, Tang E, Piao Z, Lee S, Perez M. Cutaneous Ulcer as Leading Symptom of Systemic Cytomegalovirus Infection. Case Reports In Infectious Diseases [serial on the Internet]. (2015, Feb 16), [cited April 4, 2016]; 20151-4. Available from: Academic Search Complete.
- ↑ 5.0 5.1 Ohlin M, Söderberg-Nauclér C. Human antibody technology and the development of antibodies against cytomegalovirus. Molecular Immunology [serial on the Internet]. (2015, Oct), [cited April 4, 2016]; 67(2 Pt A): 153-170. Available from: MEDLINE.
- ↑ Scripps. CMV - pneumonia. https://www.scripps.org/articles/3053-cmv-pneumonia (accessed 04 March 2016).