Multiple Myeloma: Difference between revisions
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<span class="apple-style-span"><span>Multiple myeloma is a primary | <span class="apple-style-span"><span>Multiple myeloma is a primary | ||
malignant neoplasm, or cancer, caused by uncontrolled growth of plasma cells in | malignant neoplasm, or cancer, caused by uncontrolled growth of plasma cells in | ||
the bone marrow. <span style="mso-spacerun:yes"> </span>The excessive growth of plasma cells that originate in the bone marrow destroys bone tissue and is associated with widespread osteolytic lesions (decreased areas of bone density) <ref name="Pathology text">Goodman C, Fuller K. Pathology: Implications for the Physical Therapist. St. Louis: Saunders Elsevier; 2009.</ref><ref name="Differential text">Goodman C, Snyder T. Differential Diagnosis for Physical Therapists: Screening for Referral. St. Louis: Saunders Elsevier; 2007.</ref>. </span></span> | the bone marrow. <span style="mso-spacerun:yes"> </span>The excessive growth of plasma cells that originate in the bone marrow destroys bone tissue and is associated with widespread osteolytic lesions (decreased areas of bone density) <ref name="Pathology text">Goodman C, Fuller K. Pathology: Implications for the Physical Therapist. St. Louis: Saunders Elsevier; 2009.</ref><ref name="Differential text">Goodman C, Snyder T. Differential Diagnosis for Physical Therapists: Screening for Referral. St. Louis: Saunders Elsevier; 2007.</ref>. </span></span> | ||
<span class="apple-style-span"><span>According to Goodman and Fuller, | <span class="apple-style-span"><span>According to Goodman and Fuller, | ||
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Revision as of 23:16, 5 March 2010
Original Editors - Jill Jones from Bellarmine University's Pathophysiology of Complex Patient Problems project.
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Definition/Description[edit | edit source]
Multiple myeloma is a primary malignant neoplasm, or cancer, caused by uncontrolled growth of plasma cells in the bone marrow. The excessive growth of plasma cells that originate in the bone marrow destroys bone tissue and is associated with widespread osteolytic lesions (decreased areas of bone density) [1][2].
According to Goodman and Fuller, tumors of this type initially affect the bones and bone marrow of the vertebrae, ribs, skull, pelvis, and femur. These regions are most often affected because of their high concentrations of bone marrow. The progression of this disease can cause damage to the kidney, lead to recurrent infections, and often affects the nervous system [2]. To date, multiple myeloma is an incurable disease with a poor prognosis. Most individuals die within 1 to 3 years after the diagnosis is made [1].
Prevalence[edit | edit source]
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Characteristics/Clinical Presentation[edit | edit source]
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Associated Co-morbidities[edit | edit source]
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Medications[edit | edit source]
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Diagnostic Tests/Lab Tests/Lab Values[edit | edit source]
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Causes[edit | edit source]
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Systemic Involvement[edit | edit source]
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Medical Management (current best evidence)[edit | edit source]
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Physical Therapy Management (current best evidence)[edit | edit source]
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Differential Diagnosis[edit | edit source]
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