Pancreatitis: Difference between revisions

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== Definition/Description  ==
'''''Pancreatitis'''''


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Pancreatitis is a potentially serious disorder characterized by inflammation of the pancreas that may cause autodigestion of the organ by its own enzymes. This disease has two manifestations: acute pancreatitis and chronic pancreatitis (patho 912).&nbsp;<br>
 
'''''&nbsp;&nbsp; &nbsp; Acute Pancreatitis'''''
 
&nbsp;&nbsp; &nbsp; Acute pancreatitis is the result of an inflammatory process involving the pancreas caused by the release of activated &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;pancreatic enzymes. In addition to the pancreas, this disorder can also affect surrounding organs, as well as cause a &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;systemic reaction. This form of pancreatitis is generally brief in duration, milder in symptom presentation, and reversible. &nbsp; &nbsp; &nbsp;However, while this form of the disease resolves both clinically and histologically, approximately 15% of patients with &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;acute pancreatitis will develop chronic pancreatitis (patho 912, merck 128).
 
&nbsp;&nbsp; &nbsp; Acute pancreatitis may present as mild or severe. Milder forms of acute pancreatitis involve only the interstitium of the &nbsp; &nbsp; &nbsp; &nbsp;pancreas, which accounts for 80% of all cases, and has a temperate presentation with fewer complications. However, &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;severe forms involve necrosis of the pancreatic tissue, which occurs in 20% of cases, and results in increased &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;complications and mortality (patho 912, merck 128).
 
'''''&nbsp;&nbsp; &nbsp; Chronic Pancreatitis'''''
 
&nbsp;&nbsp; &nbsp; Chronic pancreatitis develops from chronic inflammation of the pancreas that results in irreversible and progressive &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;histologic changes. This includes fibrosis and ductal strictures, which destroy the pancreas directly, as well as &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;decreased endocrine and exocrine functions, which can negatively affect other body systems. Unlike acute pancreatitis, &nbsp; &nbsp; &nbsp;this form of the disease is characterized by recurrent or persistent symptoms (patho 914 and 912, merck 128).


== Prevalence  ==
== Prevalence  ==

Revision as of 00:05, 5 March 2010

Welcome to PT 635 Pathophysiology of Complex Patient Problems This is a wiki created by and for the students in the School of Physical Therapy at Bellarmine University in Louisville KY. Please do not edit unless you are involved in this project, but please come back in the near future to check out new information!!

Original Editors - Students from Bellarmine University's Pathophysiology of Complex Patient Problems project.

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Pancreatitis

Pancreatitis is a potentially serious disorder characterized by inflammation of the pancreas that may cause autodigestion of the organ by its own enzymes. This disease has two manifestations: acute pancreatitis and chronic pancreatitis (patho 912). 

     Acute Pancreatitis

     Acute pancreatitis is the result of an inflammatory process involving the pancreas caused by the release of activated          pancreatic enzymes. In addition to the pancreas, this disorder can also affect surrounding organs, as well as cause a          systemic reaction. This form of pancreatitis is generally brief in duration, milder in symptom presentation, and reversible.      However, while this form of the disease resolves both clinically and histologically, approximately 15% of patients with          acute pancreatitis will develop chronic pancreatitis (patho 912, merck 128).

     Acute pancreatitis may present as mild or severe. Milder forms of acute pancreatitis involve only the interstitium of the        pancreas, which accounts for 80% of all cases, and has a temperate presentation with fewer complications. However,          severe forms involve necrosis of the pancreatic tissue, which occurs in 20% of cases, and results in increased                    complications and mortality (patho 912, merck 128).

     Chronic Pancreatitis

     Chronic pancreatitis develops from chronic inflammation of the pancreas that results in irreversible and progressive              histologic changes. This includes fibrosis and ductal strictures, which destroy the pancreas directly, as well as                    decreased endocrine and exocrine functions, which can negatively affect other body systems. Unlike acute pancreatitis,      this form of the disease is characterized by recurrent or persistent symptoms (patho 914 and 912, merck 128).

Prevalence[edit | edit source]

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Characteristics/Clinical Presentation[edit | edit source]

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