Original Editor - Bhanu Ramaswamy as part of the APPDE Project
Top Contributors - Kim Jackson, Admin, Rachael Lowe, Laura Ritchie, Lucinda hampton, Wendy Walker, Naomi O'Reilly, Mariam Hashem, Lauren Lopez, Bhanu Ramaswamy, Simisola Ajeyalemi, Vidya Acharya, Nikhil Benhur Abburi, Scott Buxton, Manisha Shrestha, Aminat Abolade and Tony Lowe
Parkinson's[edit | edit source]
Parkinson's disease (PD) is a neurodegenerative disorder (specifically a synucleinopathy). PD mostly presents in later life with generalized slowing of movements (bradykinesia) and at least one other symptom of resting tremor or rigidity. Other associated features are a loss of smell, sleep dysfunction, mood disorders, excess salivation, constipation, and excessive periodic limb movements in sleep (REM behavior disorder). It is the seconds most common neuro-degenerative condition in the world after Alzheimer's.
Parkinson disease is by far the most common cause of the parkinsonian syndrome, accounting for approximately 80% of cases, the remainder being due to other neurodegenerative diseases eg Lewy body dementia.
This 3 minute video gives an overview of PD
Parkinson's was described 3000 years ago in Indian and Chinese medicines with mainly plant-based remedies, however, James Parkinson was the first to describe it in the western medicine in his 1817 essay as the Shaking Palsy.
Etiology[edit | edit source]
Over the past century, our understanding of the etiology of PD has evolved immensely. PD is a disorder of the basal ganglia, which is composed of many other nuclei. The dopaminergic tract is predominantly affected in PD and it is characterised by neuronal loss of dopaminergic neurons in the substantia nigra pars compacta. Dopamine is a natural substance found in the brain that plays a major role in our brains and bodies by messaging and therefore communicating across various systems.
The cause of PD has been linked to the
- Use of pesticides, herbicides, and proximity to industrial plants.
- After injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (An accidental finding). This chemical accumulates in the mitochondria.
- Oxidation and generation of free radicals causing damage to the thalamic nuclei.
- Genes, the risk of PD in siblings is increased if one member of the family has the disorder. These cases also tend to occur much earlier in life.
- The altered function of alpha-synuclein may play a role in the etiology of PD. Current research is focussed on preventing the propagation and aggregation of alpha-synuclein
Epidemiology[edit | edit source]
Parkinson disease is by far the most common cause of the parkinsonian syndrome, accounting for approximately 80% of cases (the remainder being due to other neurodegenerative diseases, such as Lewy body dementia) and is one of the most common nervous system disorders of the aging population.
PD usually occurs after the age of 50 affecting 1 to 2 people per 1000 at any time. An estimated seven to 10 million people worldwide are living with Parkinson's. The prevalence increases with age to affect 1% of the population above 60 years. Genetics play a part in 5% to 10% of patients. It is more common in men than women, with incidence and prevalence rising with age.
Interprofessional Management[edit | edit source]
PD is one of the most common motor disorders worldwide. The disorder has no cure and is progressive. The condition can present with motor abnormalities and a variety of psychiatric and autonomic problems. Almost every organ is affected by this disorder, and as the disease progresses, management can be difficult. An interprofessional team approach is the best way to manage the disorder.
Some non-motor aspects (sleep problems, low mood, constipation, and loss of sense of smell) occur several years prior to observable motor symptoms develop. Physiotherapists are most often involved in the mid-stages of the condition, once balance and mobility become affected, but it can be helpful if they can assess and advise people soon after diagnosis in order to maintain activity and prevent problems.
Besides physicians, nurses, pharmacists, social workers, and physical therapists play a vital role in the daily management of these patients. Parkinson’s creates complexities for health and social staff helping individuals and those affected by it (carers, family members, friends). Managing these complex issues is a challenge due to the varied combinations of a motor (movement) and non-motor symptoms presented throughout the course of the condition.
Common Motor Symptoms that Require Management[edit | edit source]
- Tremor is a prominent and early symptom of PD (not always present and is not a necessary feature for diagnosis).
- Slowness, or bradykinesia, a core feature of PD.
- Rigidity is the third prominent feature on examination.
- A combination of bradykinesia and rigidity leads to some other characteristic features of PD, such as micrographia.
- The fourth prominent feature of PD is gait disturbance, although this is typically a late manifestation. Flexed posture, ataxia, reduced arm swing, festination, march-a-petits-pas, camptocormia, retropulsion, and turning en bloc are popular terms to describe the gait in PD. Gait disorder is not an early feature of PD but is frequently described as it is easy to recognize and cinches the diagnosis in later stages.
Complications to Address[edit | edit source]
- Laryngeal dysfunction
- Autonomic dysfunction
- Kyphosis leading to cardiopulmonary impairment
Prognosis[edit | edit source]
The rate of progression of the disease may be predicted based on the following:
- Males who have postural instability of difficulty with gait.
- Patients with older age at onset, dementia, and failure to respond to traditional dopaminergic medications tend to have early admission to nursing homes and diminished survival.
- Individuals with just tremors at the initial presentation tend to have a protracted benign course.
- Individuals diagnosed with the disease at older age combined with hypokinesia/rigidity tend to have a much more rapid progression of the disease.
The disorder: leads to disability of most patients within ten years; has a mortality rate three times the normal population.
Parkinson’s cannot yet be cured (treatment can improve symptoms but the quality of life is often poor). A lot of financial and other resources are being expended on research to find a cure.
Differential Diagnosis[edit | edit source]
- Essential tremor
- Huntington chorea
- Dementia with Lewy bodies
- Progressive supranuclear palsy
- Normal pressure hydrocephalus
Resources[edit | edit source]
Information about Parkinson’s can be found on the following websites:
European Parkinson’s Disease Association[edit | edit source]
The European Parkinson’s Disease Association (EPDA) is a European Parkinson's umbrella organisation. They represent 45 member organisations and advocate for the rights and needs of more than 1.2 million people with Parkinson’s and their families.
The EPDA vision is to enable all people with Parkinson's in Europe to live a full life while supporting the search for a cure.
The group launched the European Parkinson’s Disease Standards of care Consensus Statement in the European Parliament in November 2011. The document defines what the optimal management of Parkinson’s should be and what good-quality care should consist of. The document is not only developed by experts in the field of Parkinson’s but includes the voice of people with Parkinson’s. In addition to this, they have produced some amazing resources to introduce people to the condition.
Parkinson's UK[edit | edit source]
The Parkinson’s UK website hosts a lot of information about Parkinson's and management of the condition. Local support groups are also available through Parkinson's UK and are an excellent resource available to persons with Parkinson's and Parkinsonism. Often exercise groups are also provided through these groups.
Move4Parkinson's[edit | edit source]
Move4Parkinson’s was set up by Margaret Mullarney who was diagnosed with Parkinson’s in 2004. The site is dedicated to educating, empowering and inspiring People with Parkinson’s and their families or carers (Parkinson’s communities) to gain the knowledge and skills they need to improve their Quality of Life. Margaret recommends the Five Elements Framework based on her personal experience:
National Institute of Neurological Disorders and Stroke[edit | edit source]
The National Institute of Neurological Disorders and Stroke (NINDS) provides a list of American based organizations:
Viartis[edit | edit source]
Viartis is an independent, non-commercial, and self-funded medical researcher specializing in Parkinson's. Viartis is not part of any other company, university or organization, and have no religious or political allegiances. They choose articles solely on the basis of their medical significance or potential interest, and you can register to receive information free of charge. The site provides links to a range of international organizations.
Parkinson's Conference, 2009[edit | edit source]
In September 2009, SPRING (the research interest group of the Parkinson’s Disease Society) hosted a conference on the effect of exercise on Parkinson’s. Bhanu Ramaswamy was part of the organizing committee with her AGILE / ACPIN Parkinson’s Project Officer hat on, alongside Vicki Goodwin, who was also invited to speak on her research. The conference explored known aspects plus issues yet to be discovered about the benefits of exercise for people with Parkinson's. Contributions were from invited participants from across the world in the hope of enabling proposals for new research collaboration to promote exercise as an essential component of therapy for Parkinson's.
General conference information can be accessed through the website
Below are videos of the two keynote presentations from the conference:
Related pages in Physiopedia[edit | edit source]
- Anatomy, Pathology, Prognosis, and Diagnosis
- Clinical Presentation
- Drugs for the Treatment of Parkinson's
- Physiotherapy - Referral and Assessment
- Physiotherapy - Management and Interventions
- Key Evidence and resources
References[edit | edit source]
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Zafar S, Yaddanapudi SS. Parkinson disease. InStatPearls [Internet] 2019 Dec 4. StatPearls Publishing. Available from:https://www.ncbi.nlm.nih.gov/books/NBK470193/ (last accessed 6.1.2020)
- ↑ Radiopedia Parkinson disease Available: https://radiopaedia.org/articles/parkinson-disease-1(accessed 17.3.2022)
- ↑ CHI health Parkinson's Disease - Causes, Symptoms & Treatment Available from:https://www.youtube.com/watch?v=9DLw3cCfbm0 (last accessed 6.1.2020)
- ↑ Radiopedia PD Available:https://radiopaedia.org/articles/parkinson-disease-1?lang=gb (accessed 15.3.2022)
- ↑ Parkinson’s UK. The Incidence and Prevalence of Parkinson’s in the UK. London, UK. 2018.
- ↑ EPDA. Parkinson's - an overview - pt 1. Available from: http://www.youtube.com/watch?v=pqeZDFnpLpg [last accessed 29/09/16]
- ↑ Professor Alice Nieuwboer c/o SPRING (Parkinson's UK). Exercise for Parkinson’s disease: the evidence under scrutiny. Available from: https://vimeo.com/8149682 [last accessed 29/09/16]
- ↑ Professor Michael Zigmond c/o SPRING (Parkinson's UK). Exercise and Parkinson’s disease: evidence for efficacy from cellular and animal studies. Available from: https://vimeo.com/8150672 [last accessed 29/09/16]