Iliotibial Band Syndrome
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Definition/Description[edit | edit source]
Iliotibial band syndrome (ITBS) is a common knee injury that usually presents with pain and/or tenderness on palpation of the lateral aspect of the knee, superior to the joint line and inferior to the lateral femoral epicondyle.. It is considered a non-traumatic overuse injury, often seen in runners, and is often concomitant with underlying weakness of hip abductor muscles. . The current theory is that this condition is likely to be caused by compression of the innervated local adipose tissue. Studies have described an ‘impingement zone’ occurring at, or slightly below, 30° of knee flexion during foot strike and the early stance phase of running. During this impingement period in the running cycle, eccentric contraction of the tensor fascia latae muscle and of the gluteus maximus causes the leg to decelerate, generating tension (compression) in the iliotibial band.
Image: Iliotibial tract (highlighted in green) - posterior view
Clinically Relevant Anatomy[edit | edit source]
The iliotibial tract is a thick band of fascia that runs on the lateral side of the thigh from the iliac crest and inserts at the knee. It is composed of dense fibrous connective tissue that appears from the m. tensor fasciae latae and m. gluteus maximus. It descends along the lateral aspect of the thigh, between the layers of the superficial fascia, and inserts onto the lateral tibial plateau at a projection known as Gerdy’s tubercle. In its distal portion the iliotibial tract covers the lateral femoral epicondyle and gives an expansion to the lateral border of the patella. While the iliotibial band does not have any boney attachments as it courses between the Gerdy tubercle and the lateral femoral epicondyle, this absence of attachment allows it to move anteriorly and posteriorly with knee flexion and extension.
Histologic and dissection study of the iliotibial band at the lateral femoral epicondyle and gluteus maximus and fascia lata suggest a mechanosensory role acting proximally on the anterolateral knee. Figure  This mechanosensory role may affect the interpretation of the ligament versus tendon function of the ITB from hip to lateral femoral epicondyle.
Epidemiology /Etiology[edit | edit source]
ITBS is one of the most common injuries in runners presenting with lateral knee pain, with an incidence estimated to between 5% and 14%.  Further studies indicate ITBS is responsible for approximately 22% of all lower extremity injuries.
ITBS is a common cause of knee pain laterally, especially in athletes for sports involving repeated knee flexion and extension, such as cyclists and runners. Recent evidence suggests ITB contributes to rotational knee stability as well, and therefore, pivoting sports might increase the risk for ITBS.
The ITBS disease process is multifactorial, and various mechanisms have been suggested for it: repeated rubbing of the iliotibial band on the lateral femoral epicondyle during knee flexion and extension; iliotibial band impingement at 30° knee flexion; weakness of hip abductors resulting in iliotibial band overtightening during knee flexion–extension; lateral synovial recess or sub-iliotibial band bursa of the lateral knee inflammation; lateral epicondyle periosteal inflammation; and others.
Risk factors[edit | edit source]
Due to the difference in male and female anatomy, risk factors have been considered separately for each group.
A systematic review suggests associations between ITBS and peak hip adduction angle, peak hip internal rotation angle, peak knee internal rotation angle, and isometric hip abductor strength in female runners. Female runners with current ITBS have less hip internal rotation during stance phase of running compared to healthy controls. However, peak hip adduction angle had no difference during running between female runners with current ITBS and controls. Isometric hip abductor strength was also found to be lower in female runners with current ITBS compared to healthy controls.
For males, there were associations between ITBS and peak hip adduction angle. There was no difference in peak hip adduction angle during running between male runners with current ITBS and healthy controls.
Characteristics/Clinical Presentation[edit | edit source]
In many instances the subjective assessment will already provide an excellent basis for suspicion of this syndrome. Activities that require repetitive activities involving knee flexion-extension are usually reported, as well as a burning pain at the level of (or just underneath) the lateral femoral epicondyle. The diagnosis in patients with this syndrome is based on different symptoms.
The main symptom of ITBS is a sharp pain on the outer aspect of the knee, particularly when the heel strikes the floor, that can radiate into the outer thigh or calf. The pain tends to be worse when running or coming down stairs. There may be an audible snapping sensation the knee bends due to the band flicks over the bony tubercle. There may also be some swelling on the outer side of the knee.
Among the characteristics, we find an exercise-related tenderness over the lateral femoral epicondyle. The patient may experience, on a regular basis, an acute, burning pain when pressure is applied on the lateral femoral epycondyle with the knee in flexion and in extension. Signs of inflammation may also be found. There is pain on the lateral aspect of the knee during running, increasing in intensity while running down hill or descending stairs and pain is typically exacerbated when running longer distances.
The first well documented cases of ITBS were performed by Lieutenant Commander James Renne, a medical corps officer who documented on 16 ITBS cases out of 1000 military recruits. The onset occurred most frequently at the lateral knee after 2 miles of running, or hiking over 10 miles. Walking with the knee extended relieved the symptoms. All of the patients had focal tenderness over the lateral femoral epicondyle at 30 of flexion, and 5 patients had an unusual palpation described as “rubbing of a finger over a wet balloon.” 
The prevalence of ITBS in women is estimated to be between 16% and 50% and for men between 50% and 81%. 
Differential Diagnosis[edit | edit source]
Degenerative joint disease
Lateral collateral ligament (LCL) injury
Meniscal dysfunction or injury
Diagnostic Procedures[edit | edit source]
There are different provocative tests:
Outcome Measures[edit | edit source]
- Lower Extremity Functional Scale (LEFS)
- The 11-point numeric pain rating scale from Gunter and Schwellnus 
Examination[edit | edit source]
- Force of hip abduction:
The force of hip abductors can be decreased. These muscles should thus be tested.
- Treadmill test:
This test is described in several studies as a valid, effective, and sensitive method of evaluating the effects of treatments for running related pain and is used to measure the amount of pain that subjects experience during normal running. If this includes pain to the lateral side of the knee, the test is considered positive.
This test starts in supine posture and a knee flexion of 90 degrees. As the patient extends the knee the assessor applies pressure to the lateral femoral epicondyle. If this induces pain over the lateral femoral epicondyle near 30-40 degrees of flexion, the test is considered positive. A goniometer is used to ensure the correct angle of the knee joint.
The patient is lying on his side with the injured extremity facing upwards. The knee is flexed at 90 degrees and the hip in abduction and extension, the thigh is maintained in line with the trunk. The patient is invited to adduct the thigh as far as possible. The test is positive if the patient cannot adduct farther than the examination table. A positive Ober test indicates a short / tense ilio-tibial band or tensor fasciae latae, which is frequently related to the friction syndrome.
Both the Noble compression test and the Ober test can be use to examine a patient with a suspicion of Iliotibial friction syndrome. The result will be more obvious when we combine the two into one special test. For this, the position of the Ober test is adopted and compression is applied on the lateral epicondyle during passive knee extension and flexion. Moving the knee can produce more strain on the injured structures and can help to reproduce the symptoms of the patient if the combination does not. Medial patellar glide can also increase the symptoms (by tending the patellar expansion of the iliotibial band) and can reveal the precise localization while lateral glides reduces them. An internal rotation of the tibia when the knee is moved from flexion to extension can also produce the symptoms. A combination of the Nobel and Ober tests with an unloaded knee or in a weight bearing position can also be done the reproduce the symptoms.
Medical Management[edit | edit source]
Treatment of the acute inflammatory response
Activity modification to prevent further aggravation of the patient's symptoms should be the first area to be addressed in treatment. Promoting a period of active rest or substantially decreasing the intensity of the aggravating activities would be a strong starting point. Patients should be advised to participate in other physical activities, such as e.g. swimming, that do not aggravate their symptoms to maintain their conditioning. It is important to work with the patient to find a level of activity that allows them to feel confident in their rehabilitation ability and have a fair understanding of why this reduction in loading is necessary as well as working below their pain threshold . Some authors suggest complete rest from athletic activities for at least 3 weeks; other authors suggest that it is best to rest a period from 1 week to 2 months, but this rest period depends heavily on each individuals' clinical examination features.
If no improvement of symptoms occurs and inflammation persists, the following other treatment techniques might be considered:
- Ultrasound therapy, providing thermal or non-thermal treatment of the injured tissue at a frequency range of 0.75 to 3 MHz (depending on the depth of the soft tissue to be treated)
- Muscle stimulation
- Iontophoresis or phonophoresis, techniques in which medication is administered into the injured tissue through ion distribution driven by an electric field or passed through the skin using ultrasound waves, respectively. Iontophoresis with dexamethasone may be useful as an anti-inflammatory modality. 
Phonophoresis has been used in an effort to enhance the absorption of topically applied analgesics and anti- inflammatory agents through the therapeutic application of ultrasound. One study evaluated the efficacy of two ITBS treatments: phonophoresis using ultrasound to transport 10% hydrocortisone into subcutaneous tissues, and knee immobilization; the outcome suggests that receiving phonophoresis is a better treatment than just knee immobilization.
An alternative treatment strategy is radial shockwave therapy. RSWT is considered safe as it results in minor adverse effects including worsening of symptoms over a short period of time, reversible local swelling, redness and hematoma. RSWT is believed to stimulate healing of soft tissue and to inhibit nociceptors. Thus, it increases the diffusion of cytokines across vessel walls into the painful area and stimulates the tendon healing response. Shockwaves also reduce the non-myelinated sensory nerve fibres and significantly reduce calcitonin gene related peptide (CGRP), and substance-P release. Finally shockwave treatment may stimulate neo-vascularisation in the tendon-bone and bone junction, thus promoting healing.
The shockwave treatment uses energy generated when a projectile in a handpiece is accelerated py pressurized air and hits a 15-mm-diameter metal applicator. The energy is then transmitted from the applicator via ultrasound gel to the skin, where the shockwave disperses radially into the tissue to be treated.
Radial shockwave therapy is shown to be really effective as rehabilitation program for runners with iliotibial band syndrome.
Physical Therapy Management
A systematic review suggested that during follow up at 6 months, conservative treatment was effective at pain-reduction for ITBS. The treatment of ITBS is usually non-operative, and physiotherapy should be considered the first and best line of treatment.
- Exercises to stretch the iliotibial band are no longer considered as a strong evidence-based treatment approach. The best exercises to start will depend on the causative factors obtained from the subjective and objective assessment. If the lateral gluteal muscles are found to be weak or functioning improperly, this will result in compensatory muscle adaptation which can lead to excessive contraction of the iliotibial band. If the gluteal groups are too short, external rotation of the leg can occur and create abnormal stress on the iliotibial band. 
- Myofascial treatment can be effective in reducing the pain experience in acute phase, when pain and inflammation in the insertion is felt. The trigger points in Biceps femoris, vastus lateralis, gluteus maximus, and tensor fascia latae muscles will be addressed by a myofascial treatment.
- The use of a foam roller on the tight muscles could also be beneficial. The patient can also perform exercises using a foam roller at home to create deep transversal friction, self myofascial release (massage) and stretching of the muscles. A possible exercise is to lie on the side with the foam roller positioned perpendicular to the bottom leg, just below the hipbone. The upper leg should be positioned in front for balance. Using the hands for support, roll from the top of the outer thigh down to just above the knee, straightening the front leg during the movement. 
- Exercises to strengthen the abductor muscles and stabilise the hip can be helpful if clinically indicated. Here some some rehabilitative strengthening exercises:
1-Hip Bridge with Resistance Band: An effective yet simple exercise to begin with is the hip bridge utilizing a resistance band. Researchers Choi and colleagues found that gluteus maximus EMG activity was significantly greater while anterior pelvic tilt angle was significantly lower in the glute bridge with isometric hip abduction compared to the glute bridge without the band. Therefore, they concluded that performing glute bridges with isometric hip abduction against isometric elastic resistance can be used to increase gluteus maximus EMG activity and reduce anterior pelvic tilt during the exercise.
2-Side Lying Hip Abduction: The Side Lying Hip Abduction is a great way to isolate the glute medius. Distefano and colleagues looked at gluteal activation among common exercises and identified this as one of the top exercises.
3- Lateral Band Walk: Once you have isolated the gluteus medius you can now integrate a more functional exercise with the lateral band walk. Increased hip abduction strength has been shown to improve the ability of female athletes to control lower extremity alignment. When performing this exercise, the stepping motion should be performed in a semi-squat position with the knees bent rather than an upright straight leg position in order to generate greater gluteus maximus and medius muscle activity.
4-Side Plank: start by performing 3-5 repetitions for 10 seconds each, gradually adding more repetitions.
Since ITBS can often be associated with hip abductor weakness, strengthening and stabilising of the hip will be beneficial in the treatment of ITBS. Some examples of useful exercises: Hip hikes to strengthen the gluteus medius help stabilize the hip. Stand on the edge of a step with the majority of the body weight on the unaffected side. Lower the hip of the involved hip and bring it back to neutral. Another example is the side-lying hip abduction (Figure ) exercise with the back against a wall and the leg held at approximately 30° of hip abduction with slight hip external rotation and neutral hip extension. This exercise can be made more strenuous by placing a 1-metre-long band between the ankles.
Other exercises that are recommended, given the relationship of lowering body weight on one leg and neuromuscular control, are the ‘single-leg step down’ (Figure ), the ‘single-leg wall squat’ (Figure ) and the ‘single-leg dead lift’ (Figure ). 
- Hip/knee coordination and running/cycling style modification through the increase of neuromuscular control of gait.
- Cyclist are also at risk for ITBS if they tend to pedal with their toes turned in, so implementing the optimal pedalling technique may minimise the risk of developing symptoms.
Surgical Management[edit | edit source]
Open and arthroscopic surgery were shown as effective for returning athletes to sport, at a percentage between 81 and 100. During surgery, a small piece of the posterior part of the iliotibial band that covers the lateral femoral epicondyle will be resected.There is also some low level evidence to  support resolution of ITBS from the surgical excision of a bursa, cyst, or portion of a lateral synovial recess.
Surgical intervention for ITBS is often thought of as a 2nd-line treatment in which prolonged conservative treatment has failed to either alleviate the patient's symptoms or resolve ITBS. However, there is a dearth of evidence on the effectiveness of conservative therapy, so patients with ITBS could possibly miss less time from sport participation if surgery was initially performed without trialing conservative treatment first.
References[edit | edit source]
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- Iliotibial tract (highlighted in green) - posterior view image - © Kenhub https://www.kenhub.com/en/library/anatomy/iliotibial-band
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