Extrapyramidal and Pyramidal Tracts

Original Editor - Lucinda hampton

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Introduction[edit | edit source]

Upper motor neuron VS Lower motor neuron.

The Extrapyramidal and Pyramidal tracts are the pathways by which motor signals are sent from the brain to lower motor neurones. The lower motor neurones then directly innervate muscles to produce movement.

Both are motor tracts

  1. Pyramidal tracts: Conscious control of muscles from the cerebral cortex to the muscles of the body and face.
  2. Extrapyramidal tracts: Originate in the brainstem, carrying motor fibres to the spinal cord. They are responsible for the unconscious, reflexive or responsive control of musculature, eg muscle tone, balance, posture and locomotion. The reticulospinal tract is one of the most important extra-pyramidal tracts for controlling the activity of lower motor neurons.

There are no synapses within the descending pathways. At the termination of the descending tracts, the neurones synapse with a lower motor neurone. ie all the neurones within the descending motor system are classed as upper motor neurones. Their cell bodies are found in the cerebral cortex or the brain stem, with their axons remaining within the CNS[1].

Extrapyramidal Tracts (EPS)[edit | edit source]

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The EPS serves an essential function in maintaining posture and regulating involuntary motor functions. In particular, the EPS provides:

  • Postural tone adjustment
  • Preparation of predisposing tonic attitudes for involuntary movements
  • Performing movements that make voluntary movements more natural and correct
  • Control of automatic modifications of tone and movements
  • Control of the reflexes that accompany the responses to affective and attentive situations (reactions)
  • Control of the movements originally voluntary then become automatic through exercise and learning (e.g., in writing)
  • Inhibition of involuntary movements (hyperkinesias), which are particularly evident in extrapyramidal diseases.

Functionally, the EPTs can be subdivided into four.

The EPS controls the automatic activities and influences voluntary motility through a tonic function. These regulation mechanisms involve the processing of centers located in multiple brain regions eg parts of the cerebral cortex, the cerebellum, thalamus, reticular formation, and several basal ganglia (a group of subcortical nuclei).[2].

Pyramidal Tract[edit | edit source]

The Pyramidal tracts

  • Descending white matter tracts primarily concerned with motor function extending from the motor cortex (an area in the cerebral cortex where signals that trigger voluntary movement originate) down to synapse with motor neurones of the spinal cord in the anterior horns. A group of pyramidal neurons create a dense network of fibers that travels through the brain, along the brain stem, and into the spinal cord. Once in the spinal cord, the lower motor neurons connect with the nerves that innervate muscles all over the body.
  • Derive their name from the medullary pyramids of the medulla oblongata, which they pass through.[1]
  • An important part of the central nervous system, and is responsible for voluntary movements made by the body.

When a voluntary movement is made, the signal is passed along from neuron to neuron along the pyramidal tract until it reaches the desired nerves. This transmission takes place in a fraction of a second, allowing people to respond in a way that may feel instantaneous. The level of control available through the pyramidal tract is extremely precise and highly detailed, allowing people to do everything from controlling the movement of the hands during brain surgery to running a marathon[3].

Functionally, the Pyramidal tracts can be subdivided into two:

  1. Corticospinal tracts – supplies the musculature of the body.
  2. Corticobulbar tracts – supplies the musculature of the head and neck.[1]

Clinical Significance[edit | edit source]

Upper Motor Neurone Lesion

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Damage to the Pyramidal tracts are susceptible to damage, because they extend almost the whole length of the central nervous system.

Damage to the Corticospinal Tracts: Vulnerable as they pass through the internal capsule – a common site of cerebrovascular accidents (CVA). If there is only a unilateral lesion of the left or right corticospinal tract, symptoms will appear on the contralateral side of the body. The cardinal signs of an upper motor neurone lesion are:

    • Hypertonia – an increased muscle tone Hyperreflexia – increased muscle reflexes Clonus – involuntary, rhythmic muscle contractions Babinski sign – extension of the hallux in response to blunt stimulation of the sole of the foot Muscle weakness
  • Damage to the Corticobulbar Tracts: Due to the bilateral nature of the majority of the corticobulbar tracts, a unilateral lesion usually results in mild muscle weakness. However, not all the cranial nerves receive bilateral input, and so there are a few exceptions[1]

Damage to the Extrapyramidal Tracts

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Extrapyramidal tract lesions are commonly seen in neurodegenerative diseases, encephalitis and tumours. They result in various types of dyskinesias or disorders of involuntary movement.

  • Alterations affecting the various circuits play a key role in the pathogenesis of extrapyramidal motor disorders. Classic examples of injury to the EPS are Parkinson disease (PD), Huntington chorea (HC), multiple systemic atrophy (MSA), and progressive supranuclear palsy[2].
  • Depending on the specific disease, the main symptoms are alterations of the involuntary movements such as tremors, and spasms, impairment of voluntary movements as well as a decline in cognitive functions involving mainly memory tasks, and affective sphere disorders such as depression. Postural alterations are also detected.eg Pisa Syndrome.[2]

References[edit | edit source]

  1. 1.0 1.1 1.2 1.3 1.4 teach me anatomy Descending motor tracts Available from:https://teachmeanatomy.info/neuroanatomy/pathways/descending-tracts-motor/ (accessed 22.12.2020)
  2. 2.0 2.1 2.2 Lee J, Muzio MR. Neuroanatomy, Extrapyramidal System.(2020) Available from:https://www.ncbi.nlm.nih.gov/books/NBK554542/ (accessed 22.12.2020)
  3. Wise geek Pyramidal tracts Available from:https://www.wise-geek.com/what-is-the-pyramidal-tract.htm (last accessed 22.12.2020)