Amygdala

Original Editor - Lucinda hampton

Top Contributors - Lucinda hampton and Sai Kripa  

Introduction[edit | edit source]

Amygdala.gif

The amygdala is a collection of nuclei found deep within the temporal lobe. There are two amygdala, one in each cerebral hemisphere. The amygdala is recognized as a component of the limbic system, and is thought to play important roles in emotion and behavior. It is best known for its role in the processing of fear however this is an oversimplified perspective on amygdala function[1].

  • The fear of snakes and scary movies is in large part due to the function of the amygdala, which responds before frontal lobes weigh in. It’s part of our instinctive brain and serves as your “emotional thermostat.”[2]

Function[edit | edit source]

Fearfull.jpg

Early humans were exposed to the constant threat eg being killed by wild animals or other tribes. To improve the chances of survival, the startle circuit (fight- or-flight response) evolved ie an automatic response to physical danger that allows you to react quickly without thinking.

  • This response is triggered by emotions like fear, anxiety, aggression, and anger.
  • The amygdalae are most functional in immediate fear situations. Whenever our senses detect a change in our surroundings that could be dangerous, the amygdalae are responsible for preparing the body for escape or defense. This is part of what is known as the startle circuit of the brain, which controls our response to being startled[3],
  • The amygdala helps to store memories of events and emotions so that an individual may be able to recognize similar events in the future.
  • The size of the amygdala is positively correlated with increased aggression and physical behavior.
  • The amygdala in humans also plays a role in the sex drive. It can change in size and shape based on the age, hormonal activity, and gender of the individual. Eg, males who have low testosterone, or who may have been castrated, tend to have smaller amygdalae, and, in turn, may also have a lower sex drive.[3].
  • Destroying an animal’s amygdala has disastrous effects on its natural alarm system. But that does not make the amygdala the “fear centre”, because the amygdala also has connections coming in from and going out to several other parts of the brain, all of which also are needed to manifest fear[4].

Amygdala Hijack[edit | edit source]

Our world is full of stress. We often feel this psychological stress when we see things on the news or social media. eg As cases of COVID-19 proliferate, there’s a pandemic of fear unfolding alongside the pandemic of the coronavirus[5].

The amygdala respond to this stress as if it’s a physical threat to an individual. It can take control of the brain and trigger the startle circuit.

  • The symptoms of amygdala hijack are due to the effects of the two stress hormones: cortisol and adrenaline. Both hormones are released from your adrenal glands to prepare your body to flee or fight.
  • Techniques to prevent or stop an amygdala hijack include breathing slowly and deeply, slowing down, and trying to focus the mind. This allows the frontal cortex to regain control. An individual can then choose the most reasonable and appropriate way to respond to the situation.
  • Practicing these techniques regularly can help prepare individuals for stressful situations[6].
  • Studies have found that being in the presence of a calm and confident person may help overcome fear acquired through observation of others. For instance, a child terrified by a strange animal will calm down if a calm adult is present[5].

Amygdala and Addiction[edit | edit source]

Amygdala - How Emotions Happen.jpg

Addiction is considered a brain disease rather than a lack of willpower or a character defect.

  • According to a study in Brain Research, a common addiction cycle comprises three stages:preoccupation/anticipation; binge/intoxication; withdrawal/negative affect. Impulsivity often dominates at the early stages and compulsivity dominates at terminal stages.
  • The amygdala becomes recruited in the final withdrawal stage, where it sends stress signals to the body, driving a person to crave more of their substance.

Amygdala and PTSD[edit | edit source]

  • The presentation of specific traumatic tales and cues, battle sounds, conflict photos, and trauma-related terms has been shown to cause amygdala hyperresponsivity in PTSD patients.
  • Recent PET research on abuse survivors with PTSD revealed amygdala hyperresponsiveness during the learning of fear conditioning.
  • The amygdala also seems to react overly strongly to affective content unrelated to the trauma in PTSD, such as frightening facial expressions, as well as to neutral auditory oddball and continuous performance tests.
  • It is currently unknown if amygdala activation decreases with repeated exposures of affective stimuli in PTSD.
  • The degree of PTSD symptoms has been shown to positively connect with amygdala activation and self reported anxiety.[7]

The Future[edit | edit source]

Though we know much more about the amygdala since it was first discovered in the 1930s in monkeys, there’s still much to learn. Because of the amygdala’s deep brain location and its entanglement with other neighboring brain structures, it’s difficult to find exact ways to monitor its function, output and all regions that it has a synaptic influence on. Scientific studies may further our knowledge.[2]

References[edit | edit source]