Dermoneuromodulation means Dermo- Skin Neuro- Nervous system, Modulation- Change. It is a technique to change the activity of the nervous system using skin with different approaches. Diane Jacob has brought this term to light while researching the corelation of the nervous system and the pain system. DNM can be used as an adjunct to manual therapy or as it is own, because of its simple reasoning and use with minimal side effects. This approach is relatively new compared to traditional manual therapy. However, it is being performed throughout the world nowadays.